Hibernation

• Her research focuses on the physiology of animals that can overcome metabolic challenges in the brain to gain overarching insights into brain diseases.
• "While Fauna Bio is focused on data and discovery from mammals, we recognize there is important translational work being done in a broader range of species.
• This important research highlights the resilience of brain function in animals under challenging conditions that would be fatal to humans," said Ashley Zehnder, Ph.D., CEO & Co-Founder, Fauna Bio.
• The research also identified specific NMDA receptor subunits, GluN2B and GluN2C, as key players in mediating the NMDA receptor current.

• This enables 25-30 percentage points higher PA efficiency and 35% lower RRU power consumption than the industry average.
• This technology has also been applied to RRU, helping achieve power consumption as low as 3 watts when there is no traffic.
• Based on AIGC and digital twin technology, ZTE's uSmartNet achieved the industry's first smart games assurance during the event.
• This accomplishment resulted in zero major issue and zero major customer complaints, improving operational efficiency by 15% and reducing workload by 30%.

• Taking the weather forecast tradition into their own hands as the Official Beer of Groundhog Day, Samuel Adams is teaming up with DraftKings Inc. (Nasdaq: DKNG) to give drinkers a first-of-its-kind fan prediction pool: “Groundhog Day Prediction Pool Presented by Samuel Adams Cold Snap.”
  Looking to pre-game Phil’s big moment?
• Ahead of Groundhog Day, drinkers can participate in the free-to-play pool at Draftkings.com/samueladams and answer a series of Groundhog Day and sports-related questions, ultimately predicting whether or not Punxsutawney Phil will see his shadow.
• “Returning for our second year, Sam Adams is back as the Official Beer of Groundhog Day!
• “This year we’re celebrating spring alongside Samuel Adams to give customers a playful way to capture Punxsutawney Phil’s unpredictable outcomes.”
  Groundhog Day Prediction Pool Presented by Samuel Adams Cold Snap Details:
  Think you can predict the weather?!

• This long, deep rest is an example of how nature develops clever solution to difficult problems.
• In this case, how to survive a long, cold and dark period without much food and water.
• You will also find descriptions in Inuit Greenlandic stories of a prolonged hibernation-like sleep during the long dark winter months.

Animals and hibernation

• Animals that hibernate usually live longer compared to other species of the same size.
• Recent studies using epigenetic clocks, which map activity within genes over time, suggest that hibernation slows down ageing in marmots and bats.
• So hibernation may hold important clues on how to slow down ageing processes.
• New science based on epigenetic clocks and lessons from hibernating animals could help us to treat patients who have diseases driven by “wear and tear”.
• A 2018 study found that mimicking hibernation conditions for the storage of renal grafts from deceased donors seemed to improve their preservation.

Animals and longevity

• It seems like protection against inflammation, oxidative stress and modifications of proteins that happen with age are mechanism that in general benefit all long-lived animals.
• Genetic studies of rougheye rockfish, which can live for over 200 years, suggest that a food group called flavonoids is related to longevity.
• Lessons from nature and hibernating animals tell us that preserving cells, regulation metabolism and genetic adaptions play key roles in longevity.

Forty winks

• For example, a March 2023 study showed that with good quality sleep, you can add five years to the life of men and two and a half years if you are a woman.
• How elephants can become so old while sleeping so little is still a mystery to scientists.

Peter Stenvinkel receives funding from Astra Zeneca, Fresenius, Baxter, Novo Nordisk, Bayer, Invizius, Vifor for lectures and scientific advisory boards