The Kenneth Rainin Foundation

COVID-19 Virus Increases Risk for Other Infections by Disrupting Normal Mix of Gut Bacteria

Retrieved on: 
Tuesday, November 1, 2022
MPH, Hospital, Research, Infection, COVID-19, Department, Coronavirus, NYU Langone Health, National Institutes of Health, Howard Hughes Medical Institute, Man, Severe acute respiratory syndrome coronavirus 2, Schluter, Jan, Crohn's disease, Immune system, G.H. Raisoni Department of Microbiology and Biotechnology, Book of Judith, Jan Vilček, Vedanta, Cadwell, Nature Communications, Patient, New York University Grossman School of Medicine, Yale University, The Kenneth Rainin Foundation, Genetics, Risk, Physician, Bacteria, Disease, Woman, Yale School of Public Health, National, Crohn's & Colitis Foundation, Q-system (genetics), Yale school, AbbVie, Mouse, NYU, DP2, Public health, Vaccine, Antibiotics, Pharmaceutical industry, Dietary supplement, MD, Autoimmunity, Doctor of Philosophy, Medicine, Microbiology

However, researchers say, it has remained unclear until now which came first, the coronavirus infection disrupting the gut microbiome or an already weakened gut making the body more vulnerable to the virus.

Key Points: 
  • However, researchers say, it has remained unclear until now which came first, the coronavirus infection disrupting the gut microbiome or an already weakened gut making the body more vulnerable to the virus.
  • The new investigation also revealed that antibiotic-resistant species can escape into the bloodstream, putting patients at greater risk for life-threatening secondary infections.
  • These antibiotic-resistant bacteria found in the gut were also observed to have migrated into the bloodstream in 20% of patients.
  • If any bacteria group made up a majority of the bacteria living in the gut, they were considered dominant.

Norovirus Link to Crohn's Disease May Point to New Therapies

Retrieved on: 
Wednesday, October 5, 2022
Diamond, National Institutes of Health, Biochemistry, Howard Hughes Medical Institute, The Kenneth Rainin Foundation, Disease, Virus, Infection, Crohn's disease, Pharmacology, Crohn's & Colitis Foundation, API5, Geisinger Health System, NYU, Diarrhea, New York University Grossman School of Medicine, Patient, Rockefeller University, Research, MPH, Nature, Harvard Medical School, NYU Langone Health, Cadwell, Mouse, Immune system, Vomiting, Mutation, PureTech Health, Doctor of Philosophy, Department, National, Bacteria, Injection, Pacific Biosciences, Apoptosis, Human, Vaccine, Pharmaceutical industry, Pfizer, Takeda, Genentech, MD, Norovirus, Microbiology

Norovirus, a common infection that causes vomiting and diarrhea, is one of several viruses and bacteria thought to trigger disease onset in Crohn's patients, but the field does not know why.

Key Points: 
  • Norovirus, a common infection that causes vomiting and diarrhea, is one of several viruses and bacteria thought to trigger disease onset in Crohn's patients, but the field does not know why.
  • One clue emerged when past studies found that a certain genetic change (mutation) is present in most patients with the condition.
  • This protein adds an extra layer of protection against immune damage, so even those with the mutation can have a healthy gut.
  • However, the researchers also found that norovirus infection blocks T cell secretion of API5 in mice bred to have a rodent form of Crohn's disease, killing gut-lining cells in the process.

Mettler Toledo Rainin Expands Operations in Vacaville

Retrieved on: 
Wednesday, July 13, 2022
Genentech, Interstate Highway System, Alza, General manager, LLC, Acquisition, City, GLOBE, Mettler Toledo, Interstate 80, University, Campus of the University of California, Berkeley, Fine chemical, Polaris, The Kenneth Rainin Foundation, Chiron

Rainin, a part of the Mettler Toledo family, manufactures liquid handling instruments and consumables for the life sciences industry.

Key Points: 
  • Rainin, a part of the Mettler Toledo family, manufactures liquid handling instruments and consumables for the life sciences industry.
  • We are excited to expand our manufacturing operations in Vacaville, said Werner Maas, General Manager for Rainin.
  • I couldnt be more pleased that Rainin has chosen to invest in the City of Vacaville.
  • Mettler-Toledo Rainin, LLC is part of METTLER TOLEDO, a global manufacturer and marketer of precision instruments for use in laboratory, industrial and food retailing.

Kenneth Rainin Foundation Announces Earlier Funding For Innovator Awards

Retrieved on: 
Tuesday, September 15, 2020
Clinical research, Principal investigator, The Kenneth Rainin Foundation

The Foundation will accept applications from a single Principal Investigator (PI) or a group of investigators, and from researchers at both nonprofit and for-profit institutions worldwide.

Key Points: 
  • The Foundation will accept applications from a single Principal Investigator (PI) or a group of investigators, and from researchers at both nonprofit and for-profit institutions worldwide.
  • Current and former Rainin Foundation Innovator and Synergy Award grantees are welcome to apply for funding for a new research project.
  • Researchers who are interested in collaborative projects can still apply for funding through the Innovator Awards.
  • Visit krfoundation.org/ibd to learn about the Rainin Foundations research grantees and funding areas, as well as our vision and strategy for solving IBD.

Newly Funded Public Art Projects Center Community Stories And Participation

Retrieved on: 
Tuesday, February 25, 2020
Public art, The Kenneth Rainin Foundation

When designed with the community, public art has the power to create space for and give voice to underrepresented groups, said Adriana Gri, Arts Program Officer.

Key Points: 
  • When designed with the community, public art has the power to create space for and give voice to underrepresented groups, said Adriana Gri, Arts Program Officer.
  • The Open Spaces Program supports nonprofits to partner with artists to create temporary, place-based public art projects in San Francisco and Oakland.
  • These projects showcase the significant role that artists can play in initiating and expanding conversations about the most critical issues of our time.
  • The Rainin Foundations inaugural Open Spaces Program grantees created three community-driven public art projects in 2017.

Grant Opportunity To Improve Prediction And Prevention Of IBD

Retrieved on: 
Tuesday, January 7, 2020
The Kenneth Rainin Foundation

Complete program information, eligibility requirements, guidelines and frequently asked questions can be found at krfoundation.org/innovator-awards .

Key Points: 
  • Complete program information, eligibility requirements, guidelines and frequently asked questions can be found at krfoundation.org/innovator-awards .
  • In addition to its grant programs, the Rainin Foundation hosts an annual Innovations Symposium to connect researchers with tools, knowledge and potential collaborators.
  • Fourteen speakers working within and outside of the field of IBD have been confirmed for the event.
  • Visit krfoundation.org/ibd to learn about the Rainin Foundations research grantees and funding areas, as well as its vision and strategy for solving IBD.

Kenneth Rainin Foundation Awards Over $2 Million To Advance IBD Research

Retrieved on: 
Tuesday, October 22, 2019
The Kenneth Rainin Foundation, Autoimmune diseases, Inflammatory bowel disease, IBD

Oakland, Calif., Oct. 22, 2019 (GLOBE NEWSWIRE) -- The Kenneth Rainin Foundation has awarded $2.2 million through its Innovator Awards to advance Inflammatory Bowel Disease (IBD) research and improve patient outcomes.

Key Points: 
  • Oakland, Calif., Oct. 22, 2019 (GLOBE NEWSWIRE) -- The Kenneth Rainin Foundation has awarded $2.2 million through its Innovator Awards to advance Inflammatory Bowel Disease (IBD) research and improve patient outcomes.
  • For the first time in the Rainin Foundations Health funding, half of the new Innovator Awards will support female investigators.
  • This turning point comes as the Rainin Foundation celebrates 10 years of formal grantmaking and is working to embed equity in its work.
  • Since 2010, the Foundation has awarded over $11 million for promising scientific research projects with the potential to impact treatment and prevention of Inflammatory Bowel Disease.