Protein misfolding cyclic amplification

Vaxxinity Announces First Parkinson’s Disease Patient Dosed in Part B of Phase 1 Clinical Trial of UB-312

Retrieved on: 
Wednesday, January 12, 2022

We are delighted to achieve another milestone for Vaxxinity as we initiate the next part of our clinical program in Parkinsons, an indication with clear unmet needs for a large patient population, said Mei Mei Hu, Chief Executive Officer of Vaxxinity.

Key Points: 
  • We are delighted to achieve another milestone for Vaxxinity as we initiate the next part of our clinical program in Parkinsons, an indication with clear unmet needs for a large patient population, said Mei Mei Hu, Chief Executive Officer of Vaxxinity.
  • Developing vaccines that target chronic and difficult-to-treat diseases like Parkinsons are integral to our vision of providing cheaper, safer and more effective medicines to the world.
  • Parkinsons disease currently affects approximately one million people in the United States and more than 10 million people worldwide.
  • Clinical data from Part A of the Phase 1 trial indicate that UB-312 elicits antibody levels sufficient to cross the BBB (i.e., detectable in CSF).

Vaxxinity Awarded Grant from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to Support UB-312 Vaccine Study

Retrieved on: 
Monday, January 10, 2022

Fox Foundation for Parkinsons Research (MJFF) for the exploration of markers for target engagement in individuals with Parkinsons disease (PD).

Key Points: 
  • Fox Foundation for Parkinsons Research (MJFF) for the exploration of markers for target engagement in individuals with Parkinsons disease (PD).
  • Vaxxinity is developing its PD vaccine candidate UB-312, which has completed Part A of a first-in-human study in healthy volunteers and is advancing to Part B in Parkinsons patients.
  • This award from MJFF will support the discovery and development of relevant pharmacodynamic markers.
  • UB-312 is designed to target pathological forms of aSyn for the treatment and prevention of synucleinopathies, including PD.

When Prions are Personal

Retrieved on: 
Monday, October 21, 2019

Almost everyone produces the prion protein, known as PrP for short, which is found in the brain and cerebrospinal fluid.

Key Points: 
  • Almost everyone produces the prion protein, known as PrP for short, which is found in the brain and cerebrospinal fluid.
  • For husband-and-wife team Sonia Vallabh and Eric Vallabh Minikel, prions became personal when Vallabh's mother died of a mysterious, rapidly-advancing neurodegenerative disease.
  • Some early trials in mice give Minikel hope, he said: mice infected with prions, if treated before they show symptoms, survive longer without disease.
  • The Society publishes three journals: the Journal of Biological Chemistry, the Journal of Lipid Research, and Molecular and Cellular Proteomics.