Capsaicin

Human medicines European public assessment report (EPAR): Qutenza, capsaicin, Date of authorisation: 15/05/2009, Revision: 19, Status: Authorised

Retrieved on: 
Tuesday, January 2, 2024

Human medicines European public assessment report (EPAR): Qutenza, capsaicin, Date of authorisation: 15/05/2009, Revision: 19, Status: Authorised

Key Points: 


Human medicines European public assessment report (EPAR): Qutenza, capsaicin, Date of authorisation: 15/05/2009, Revision: 19, Status: Authorised

Sorrento Therapeutics Announces Positive Phase 2a Clinical Trial Results for Resiniferatoxin (RTX) for the Treatment of Knee Pain in Moderate to Severe Osteoarthritis of the Knee (OAK) Patients

Retrieved on: 
Thursday, September 7, 2023

RTX 20mcg and 12.5mcg have been selected as the clinically optimal and minimally effective doses for further phase 2 pivotal or phase 3 trials.

Key Points: 
  • RTX 20mcg and 12.5mcg have been selected as the clinically optimal and minimally effective doses for further phase 2 pivotal or phase 3 trials.
  • SAN DIEGO, Sept. 07, 2023 (GLOBE NEWSWIRE) -- Sorrento Therapeutics, Inc. (OTC: SRNEQ, "Sorrento") announced today positive Phase 2a top-line clinical trial results for the RTX program.
  • A higher proportion of patients responded to treatment with RTX 20mcg than any other treatment group, including Zilretta.
  • The clinical trial confirmed the potential of resiniferatoxin (RTX) in helping patients with moderate to severe osteoarthritis pain for at least 6 months, if not longer.

Australian Dream® Introduces Power 4™ --An Innovative Muscle and Joint Pain Cream

Retrieved on: 
Tuesday, August 29, 2023

Topical analgesics are creams, gels, sprays or patches that provide relief through active ingredients applied directly to the surface of the skin.

Key Points: 
  • Topical analgesics are creams, gels, sprays or patches that provide relief through active ingredients applied directly to the surface of the skin.
  • But not all topical pain relief creams are created equal.
  • Unlike other topical analgesics, Power 4™ Muscle and Joint Pain Cream contains four of the six most common FDA-approved active ingredients: camphor (3%), menthol (3%), capsaicin (0.025%) and methyl salicylate (10%).
  • The unique formula of Power 4™ also features warming and cooling action and anti-inflammatory medicine (NSAID) to relieve pain in muscles and joints.

To Chile or Not to Chile? That Is the Question for the 1 Out of 7 People Affected Worldwide by IBS

Retrieved on: 
Monday, August 21, 2023

SOUTH WEST, Colo., Aug. 21, 2023 /PRNewswire/ -- Stomach sensitivity doesn't necessarily mean you have to avoid consuming chile peppers. That is why American Southwest author Amy Laura introduces Calm Tummy Happy Heart, the first Low FODMAP cookbook from the U.S. with recipes certified by Monash University.

Key Points: 
  • "When I began recipe testing, I was concerned that an IBS diet would require bland ingredients, and that chile peppers would need to be eliminated," says Laura.
  • Within three days of eating strictly low FODMAP portions of foods, Laura felt relief for the first time in three decades."
  • A team on the management of IBS conducted by the American College of Gastroenterology suggested that a low FODMAP diet can be used for overall symptom improvement in IBS.
  • Following a low FODMAP diet can offer relief for 70 to 75 percent of those dealing with IBS related symptoms.

Tonix Pharmaceuticals Announces Clinical Proof-of-Concept Study of TNX-1900 (Intranasal Potentiated Oxytocin)

Retrieved on: 
Monday, May 22, 2023

CHATHAM, N.J., May 22, 2023 (GLOBE NEWSWIRE) -- Tonix Pharmaceuticals Holding Corp. (Nasdaq: TNXP), a clinical-stage biopharmaceutical company, today announced that it has entered into a research collaboration agreement to evaluate the effect of TNX-1900 (intranasal potentiated oxytocin) on capsaicin- or electrical stimulation-induced forehead dermal blood flow in healthy female human volunteers. Dr. Antoinette Maassen van den Brink, Professor of Neurovascular Pharmacology, Erasmus University Medical Center, will serve as principal investigator for the study.

Key Points: 
  • Dr. Antoinette Maassen van den Brink, Professor of Neurovascular Pharmacology, Erasmus University Medical Center, will serve as principal investigator for the study.
  • “Collaborating with Professor Maassen van den Brink is an exciting opportunity to learn about the potential for TNX-1900 for treating migraine, facial pain and other related conditions,” said Seth Lederman, M.D., Chief Executive Officer of Tonix Pharmaceuticals.
  • Oxytocin represents a potential new therapeutic option, targeting a pathway in migraine that is distinct from the recently available CGRP inhibitor migraine treatment drug class.”
    In February 2023, Tonix initiated enrollment in its Phase 2 PREVENTION study of TNX-1900 for chronic migraine.
  • The Company expects topline results in the fourth quarter of this year.

Kanazawa University research: Experiments reveal chilli-sensitive molecular structure fluctuation changes in TRPV1

Retrieved on: 
Tuesday, May 9, 2023

However, the mechanisms behind the function of TRPV1 have not been clear.

Key Points: 
  • However, the mechanisms behind the function of TRPV1 have not been clear.
  • Now Ayumi Sumino at Kanazawa University in Japan and Motoyuki Hattori at the Fudan University in China and their colleagues provide important insights into this mechanism.
  • Once activated, the TRPV1 channel opens, allowing ions to permeate and signalling to the nervous system that a noxious stimulant is present.
  • Antithetic effects of agonists and antagonists on the structural fluctuations of TRPV1 channel, Proceedings of the National Academy of Sciences May 8, 2023.

Kanazawa University research: Experiments reveal chilli-sensitive molecular structure fluctuation changes in TRPV1

Retrieved on: 
Tuesday, May 9, 2023

However, the mechanisms behind the function of TRPV1 have not been clear.

Key Points: 
  • However, the mechanisms behind the function of TRPV1 have not been clear.
  • Now Ayumi Sumino at Kanazawa University in Japan and Motoyuki Hattori at the Fudan University in China and their colleagues provide important insights into this mechanism.
  • Once activated, the TRPV1 channel opens, allowing ions to permeate and signalling to the nervous system that a noxious stimulant is present.
  • Antithetic effects of agonists and antagonists on the structural fluctuations of TRPV1 channel, Proceedings of the National Academy of Sciences May 8, 2023.

Reviva Pharmaceuticals to Host Key Opinion Leader Event on Brilaroxazine (RP5063) in Phase 3 Clinical Trials for Schizophrenia

Retrieved on: 
Tuesday, April 25, 2023

He will look at brilaroxazine, a next-generation serotonin-dopamine modulator, and its potential as a treatment solution for schizophrenia.

Key Points: 
  • He will look at brilaroxazine, a next-generation serotonin-dopamine modulator, and its potential as a treatment solution for schizophrenia.
  • The Reviva leadership team will provide an overview of the efficacy and safety data generated in the clinical trials completed to date and an update on ongoing RECOVER Phase 3 trial evaluating brilaroxazine in patients with acute schizophrenia.
  • Brilaroxazine is a new chemical entity with broad therapeutic potential in neuropsychiatric and inflammatory conditions arising from underlying dysfunction in serotonin and dopamine signaling.
  • Dr. Ereshefsky’s unique perspective as a clinical scientist (clinical psychiatric pharmacist and psychopharmacologist) helps to guide drug development from preclinical to late Phase.

HEATONIST Brings Hot Sauces from Hot Ones™, Dustin Poirier and Secret Handshake Lines to the Condiment Aisle

Retrieved on: 
Wednesday, April 12, 2023

BROOKLYN, N.Y., April 12, 2023 /PRNewswire-PRWeb/ -- HEATONIST is growing beyond the world's #1 online destination for hot sauce by bringing its passion for all-natural, small-batch sauces to the Walmart condiment aisle. In its first major foray onto national retail shelves for year-round availability, HEATONIST is expanding partnerships with First We Feast's "Hot Ones" series, UFC fighter Dustin Poirier, and content creators Joe Santagato and Greg Dybec of Santagato Studios / Secret Handshake Food Co. to launch several best-selling SKUs at Walmart stores across the Midwest, Southeast and East Coast:

Key Points: 
  • Top-selling hot sauces from HEATONIST's partnership hot sauce lines are now available at thousands of Walmart stores in first major foray into national retail.
  • BROOKLYN, N.Y., April 12, 2023 /PRNewswire-PRWeb/ -- HEATONIST is growing beyond the world's #1 online destination for hot sauce by bringing its passion for all-natural, small-batch sauces to the Walmart condiment aisle.
  • Poirier's Louisiana Style Hot Sauce , for example, was created as a collaboration with UFC fan-favorite Dustin Poirier, his team at Dulcedo Management and sauce maker Heartbeat Hot Sauce.
  • Visit heatonist.com/pages/where-to-buy to find HEATONIST hot sauces at a Walmart store and sauce up today.

Thermo Weight Control Helps You Burn Fat at Rest

Retrieved on: 
Wednesday, January 4, 2023

That’s because when you eat less, your body may burn less energy (theoretically storing calories for future needs).

Key Points: 
  • That’s because when you eat less, your body may burn less energy (theoretically storing calories for future needs).
  • To support the body’s ability to burn fat for energy even when calorie intake is lower, scientists at Life Extension have developed Thermo Weight Control .
  • The ideal companion to an active lifestyle and low-calorie diet, this innovative new weight management formula features a patented red chili extract clinically studied to encourage fat burning.
  • Thermo Weight Control daily supplement is the newest addition to Life Extension’s weight management lineup.