Abcuro and ImaginAb Share Initial Results of Study Using Novel Technology for Imaging T Cell Infiltration of Skeletal Muscle in Patients with Inclusion Body Myositis
IBM is an autoimmune disease in which cytotoxic CD8+ T cells chronically attack muscle cells, leading to progressive weakness and severe disability.
- IBM is an autoimmune disease in which cytotoxic CD8+ T cells chronically attack muscle cells, leading to progressive weakness and severe disability.
- The proprietary first in class ImmunoPET imaging agent allows non-invasive, whole-body imaging CD8+ T cells using positron emission tomography (PET).
- The technology, initially designed to visualize these cells in cancer patients, can now provide a non-invasive assessment of the extent of infiltration of CD8+ T cells in skeletal muscle in IBM patients.
- ImaginAb engineers antibody fragments called minibodies that maintain the exquisite specificity of full-length antibodies while remaining biologically inert in the body.