The Best Thing Since Sliced Tissue
SAN FRANCISCO, Aug. 17, 2023 /PRNewswire/ -- Imagine a few roughly cut slices of bread on a plate. With just those slices, could you picture, in fine detail, the loaf they came from?
- This approach, published in the journal Nature Methods, could allow for much deeper understanding of biological tissue samples.
- This statistical approach harnesses data from the 2D tissue slices and, in the first layer, fits the warped 2D slice onto a 3D model of the tissue.
- During this process, the GPSA model fills in the spaces between slices with predictions of gene or protein expression for every point throughout the tissue, ultimately generating a 3D "atlas" of the tissue.
- In addition, when applied to slices taken from the same tissue at different points in time, GPSA can generate atlases that predict how every location within the tissue changes over time.