A-Alpha Bio Collaborates with Amgen to Identify and Validate Ligase-Target Pairs for Molecular Glue Discovery
SEATTLE, Sept. 26, 2023 /PRNewswire-PRWeb/ -- A-Alpha Bio (A-Alpha), a synthetic biology and machine learning company that measures and engineers protein-protein interactions, today announced the expansion of their collaboration with Amgen's Induced Proximity Platform to characterize interactions between ligases and molecular glue targets for protein degradation.
- We look forward to expanding our collaboration and moving into the validation of glueability and the generation of data to inform rational molecular glue discovery.
- Following review of the results from the initial collaboration and additional work carried out by Amgen, A-Alpha and Amgen have agreed to an expanded collaboration.
- Under the expanded collaboration agreement, A-Alpha will further interrogate selected pairs to evaluate glueability and provide structural insights expected to enable rational design of molecular glue degraders.
- "We look forward to expanding our collaboration and moving into the validation of glueability and the generation of data to inform rational molecular glue discovery.