Cerebral organoid

City of Hope Researchers Develop Miniature Brain Models to Study the Causes of Alzheimer’s Disease and to Test Drugs in Development

Retrieved on: 
Monday, August 2, 2021
Oncology, Health, Hospitals, Other Health, Other Science, Research, Science, Branches of biology, Biology, Stem cells, Life sciences, Organoid, Cerebral organoid, Induced pluripotent stem cell

We, at City of Hope, have created a miniature brain model that uses human stem cell technology to study Alzheimers disease and, hopefully, to help find treatments for this devastating illness.

Key Points: 
  • We, at City of Hope, have created a miniature brain model that uses human stem cell technology to study Alzheimers disease and, hopefully, to help find treatments for this devastating illness.
  • City of Hope researchers were able to model sporadic Alzheimers disease, the most common form of the condition, using brain organoids derived using human induced pluripotent stem cell (hiPSC) technology.
  • Because Alzheimers is a disease of age, the scientists exposed the models to serum to mimic age-associated blood-brain barrier breakdown.
  • Huentelman is a leading expert in the genetic study of Alzheimers disease and was not part of this study.

Tempus Unveils Its Scalable Tumor Organoid Screening Platform In Cell Reports Study

Retrieved on: 
Wednesday, July 28, 2021
Oncology, Health, Technology, Surgery, Other Technology, Software, Biotechnology, Branches of biology, Biology, Natural sciences, Stem cells, Organoid, Tissue engineering, Assay, Precision medicine, Cerebral organoid

Tempus , a leader in artificial intelligence and precision medicine, today announced publication of a study outlining the precision medicine applications for its patient-derived tumor organoid (TO) platform.

Key Points: 
  • Tempus , a leader in artificial intelligence and precision medicine, today announced publication of a study outlining the precision medicine applications for its patient-derived tumor organoid (TO) platform.
  • Given the scale of Tempus organoid program, it now houses one of the largest repositories of these models in the world.
  • Overall, the Tempus organoids accurately represented patients tumor DNA mutational profiles, RNA expression, and structural genomic features.
  • Lastly, the study presents a neural network-based, universal solid tumor therapeutic profiling assay predicting organoid viability from simple light microscopy, reducing cost and time in high-throughput screening.

AIVITA Biomedical and University of California at Irvine Collaborators Validate 3D Printed Bioreactor for Retinal Organoid Creation

Retrieved on: 
Tuesday, July 13, 2021
Branches of biology, Stem cells, Biology, Organoid, Tissue engineering, Retina, Cerebral organoid

In the study, researchers from AIVITA Biomedical and the University of California at Irvine designed and demonstrated a bioreactor for nearly labor-free retinal organoid maintenance.

Key Points: 
  • In the study, researchers from AIVITA Biomedical and the University of California at Irvine designed and demonstrated a bioreactor for nearly labor-free retinal organoid maintenance.
  • Retinal degeneration is a leading cause of vision impairment and blindness worldwide, with limited treatment options available for advanced stages of the disease.
  • In this study, researchers designed a shear stress-free micro-millifluidic bioreactor for nearly labor-free retinal organoid maintenance.
  • The result was the successful creation of bioreactor-cultured retinal organoids with cell types and morphology comparable to static cultured retinal organoids and exhibiting similar retinal gene expression levels.

Applied Bio Study Uncovers Major Breakthrough in Understanding and Treating Respiratory Inflammation

Retrieved on: 
Tuesday, June 22, 2021
Health, Infectious diseases, Research, Pharmaceutical, Science, Biotechnology, Branches of biology, Medical specialties, Biology, Stem cells, Organoid, Tissue engineering, Respiratory disease, Inflammation, Cerebral organoid

The study results also showed that almost all of the leading OTC products on the market can damage the upper respiratory cells and may prolong illness.

Key Points: 
  • The study results also showed that almost all of the leading OTC products on the market can damage the upper respiratory cells and may prolong illness.
  • This research study and its findings represent one of the first major breakthroughs in decades for the cold and flu market.
  • Alternatively, this study shows that the ingredients in Biovanta offer a safe and effective treatment for inflammation vs. a reduction of the symptoms.
  • This study is a major breakthrough in understanding the underlying mechanism of inflammation in upper respiratory illnesses, which wasnt possible until recent scientific advancements that enabled the creation of organoids for use in testing human tissue reactions, said Nazlie Latefi, PhD, co-founder and chief science officer, Applied Bio.

Worldwide Organoids Industry to 2026 - by Organ, Application, End-user and Geography - ResearchAndMarkets.com

Retrieved on: 
Wednesday, June 9, 2021
Biotechnology, Health, Stem cells, Pharmaceutical, Oncology, Stem cells, Organoid, Tissue engineering, Cerebral organoid

The "Organoids Market - Forecasts from 2021 to 2026" report has been added to ResearchAndMarkets.com's offering.

Key Points: 
  • The "Organoids Market - Forecasts from 2021 to 2026" report has been added to ResearchAndMarkets.com's offering.
  • The organoids demonstrate similar organ functionalities to those present in various organs and have the ability to self-renew and self-organize themselves.
  • The organoids market has been classified on the basis of organ, application, end user, and geography.
  • Geographically, the market for Organoids has been distributed into North America, South America, Europe, Middle East and Africa, and Asia Pacific.

Asia Pacific Organoids Market Forecast to 2027: Amalgamation of Organ-on-Chip with Organoids to be a Prevalent Trend - ResearchAndMarkets.com

Retrieved on: 
Monday, April 19, 2021
Health, Biotechnology, Tissue engineering, Stem cells, Biology, Life sciences, Organoid, Technology, Organ-on-a-chip, Cerebral organoid

b'The "Asia Pacific Organoids Market Forecast to 2027 - COVID-19 Impact and Regional Analysis By Type; Application; Source, and Country" report has been added to ResearchAndMarkets.com\'s offering.\n\'Asia-Pacific Organoids Market is expected to reach US$ 513.74 Mn in 2027 from US$ 97.02 Mn in 2019.

Key Points: 
  • b'The "Asia Pacific Organoids Market Forecast to 2027 - COVID-19 Impact and Regional Analysis By Type; Application; Source, and Country" report has been added to ResearchAndMarkets.com\'s offering.\n\'Asia-Pacific Organoids Market is expected to reach US$ 513.74 Mn in 2027 from US$ 97.02 Mn in 2019.
  • The market is estimated to grow with a CAGR of 23.1% from 2020-2027.\nOrganoid and organ-on-a-chip, which are served as evolving pathological and human physiological relevant in vitro models, hold an excessive potential to revolutionize the conventional example in basic and clinical research.\nThe recent inclination in the collaborative application of organoid with organ-on-a-chip and 3D bio printing enables development of sophisticated cancer models to study underlying mechanisms of tumour-stroma interactions, multi-organ tumour metastasis, and cancer-microenvironment interactions.\nBy incorporating multiple organoids into organ-on-a-chip, organoid-on-a-chip can inherit both organoid and organ-on-a-chip benefits and provides a useful tool to study multi-organ tumour metastases and cancer-microenvironment interactions.
  • Overall, researchers expect that these emerging in vitro cancer model systems will ultimately revolutionize the conventional paradigm of cancer research and produce real clinical benefits.\nKey driving factor such as rising adoption of bio-banking and tumour modelling and alternatives for animal testing models acting as kingpins are expected to augment the growth of the market.
  • However, lack of expertise is likely to have a negative impact on the growth of the market in the coming years.\n'

Scientist.com Partners with Top CROs to Offer Disease Models for Cancer Research

Retrieved on: 
Thursday, April 1, 2021
Research, Technology, Clinical trials, Software, Biotechnology, Pharmaceutical, Health, Data management, Science, Oncology, Stem cells, Branches of biology, Biology, Organoid, Tissue engineering, Life sciences, Xenotransplantation, Patient derived xenograft, Cerebral organoid

Scientists can filter by gene mutation, gene expression, cancer type or patient information, and then purchase without delay once the right model is identified.

Key Points: 
  • Scientists can filter by gene mutation, gene expression, cancer type or patient information, and then purchase without delay once the right model is identified.
  • The Disease Model Finder brings together a wealth of data that can help scientists choose the right preclinical disease models.
  • Marketplace customers can then filter their search results based on cancer type, subtype and characteristics or patient information.
  • By 2022, the platform will include other model systems including organoids, cell-derived xenografts (CDX), syngeneic models, immunoncology models and patient-derived cell lines.

New Models in Organoids Market Open New Vistas in Stem Cell Research for Cancer, Global Valuation to Reach US$ 12.8 Bn by 2030: TMR

Retrieved on: 
Tuesday, January 12, 2021
Stem cells, Branches of biology, Organoid, Tissue engineering, Scientific modelling, Cerebral organoid

The technologies in the organoids market have emerged as a novel culture used for human disease modelling.

Key Points: 
  • The technologies in the organoids market have emerged as a novel culture used for human disease modelling.
  • Advent of new methods in generating 3D structures are opening new vistas in human disease modelling, particularly in virology.
  • Europe and North America have emerged as the new hotspots for patient-derived human organoid studies in the global organoids market.
  • The revenue of global organoid market is projected to climb from US$ 1.7 Bn in 2019 to touch the mark of US$ 12.8 Bn by 2030.

New Models in Organoids Market Open New Vistas in Stem Cell Research for Cancer, Global Valuation to Reach US$ 12.8 Bn by 2030: TMR

Retrieved on: 
Tuesday, January 12, 2021
Stem cells, Branches of biology, Organoid, Tissue engineering, Scientific modelling, Cerebral organoid

The technologies in the organoids market have emerged as a novel culture used for human disease modelling.

Key Points: 
  • The technologies in the organoids market have emerged as a novel culture used for human disease modelling.
  • Advent of new methods in generating 3D structures are opening new vistas in human disease modelling, particularly in virology.
  • Europe and North America have emerged as the new hotspots for patient-derived human organoid studies in the global organoids market.
  • The revenue of global organoid market is projected to climb from US$ 1.7 Bn in 2019 to touch the mark of US$ 12.8 Bn by 2030.

World Human Organoids (Pancreas, Kidney, Lung, GIT, Liver Models) Market Report 2020 - ResearchAndMarkets.com

Retrieved on: 
Wednesday, December 30, 2020
Biotechnology, Pharmaceutical, Health, Stem cells, Organoid, Tissue engineering, Organ transplantation, Cerebral organoid

The global human organoids market size is projected to reach USD 1,901 million by 2025 from USD 850 million in 2020, at a CAGR of 17.5%.

Key Points: 
  • The global human organoids market size is projected to reach USD 1,901 million by 2025 from USD 850 million in 2020, at a CAGR of 17.5%.
  • Factors such as the technological advancements in the market are propelling the growth of the human organoids market.
  • Additionally, rising cases of transplants, investments from both private and public sectors are having affect in the growth of human organoids market.
  • "The developmental biology accounted for the largest share of the human organoids market, by human organoids, in 2020."