Novel sex-determination mechanism revealed in mammals
SAPPORO, Japan, Nov. 28, 2022 /PRNewswire/ -- In mammals, the distinction between male and female at the chromosomal level is due to the X and Y chromosomes. Typically, females have two X chromosomes (XX) while males have an X and a Y chromosome (XY). The Sry gene on the Y chromosome triggers the formation of the testes. However, there exist a handful of rodent species in which the Y chromosome has disappeared, taking with it the Sry gene. The mechanism by which testes development occurs in these species is not fully understood, and is subject to much research.
- In the Amami spiny rat, the the Sry gene is completely absent; thus, it has evolved a novel, unknown sex-determining mechanism independent of Sry.
- This study is the first discovery of a male-specific genetic element directly related to sex-determining mechanism in mammals that is independent of Sry.
- It shows that the the sex-determination mechanism in the Amami spiny rat has moved to chromosome 3, an autosome the first example of a translocation of sex-determination mechanism in mammals.
- Future work will focus on investigating the exact mechanism by which Enh14 acts, as well as identifying other elements of this novel mechanism.