Neurotoxicity

• LOS ANGELES, Sept. 07, 2023 (GLOBE NEWSWIRE) -- Immix Biopharma, Inc. (Nasdaq: IMMX) (“ImmixBio”, “Company”, “We” or “Us”) a clinical-stage biopharmaceutical company pioneering personalized therapies for oncology and immunology, today announced that Nexcella NXC-201 clinical data will be presented by Ilya Rachman, MD, PhD, and Gabriel Morris at the Healthcare Trailblazers Private Company Conference Thursday, October 26, 2023.
• At this institutional event, Ilya Rachman and Gabriel Morris will plan on being available to meet institutional investors and potential strategic pharmaceutical partners.
• “We are delighted to present the clinical progress we are making with our CAR-T, NXC-201, at this premier healthcare conference,” said Ilya Rachman MD PhD, Chief Executive Officer of Immix Biopharma.
• Gabriel Morris, Chief Financial Officer of Immix Biopharma, added, “We believe the addressable market of CAR-Ts today is limited by neurotoxicity, which restricts dosing to only 5% of U.S. hospitals.

• “We are pleased with the growing body of evidence that supports ALZ-801’s potential as the first oral disease modifying therapy for Alzheimer’s disease.
• In mechanism of action studies, ALZ-801 fully blocked the formation of neurotoxic soluble beta amyloid (Aβ) oligomers at the Phase 3 clinical dose.
• In November 2022, Alzheon reported positive study results from a pre-specified analysis following 52 weeks of treatment with ALZ-801.
• An ongoing long-term extension of the trial evaluates ALZ-801 for an additional 52 weeks of treatment for a total of 156 weeks.

• OLPRUVA™ is approved in the U.S. for the treatment of certain urea cycle disorders (UCDs).
• Acer and Relief have now agreed to terminate the CLA, where Acer is no longer required to pay Relief 60% of OLPRUVA™ net profits in the Acer territories and have regained all development and commercialization rights in rest of the world, excluding the Geographical Europe.
• Additionally, Acer and Relief have entered into a new Exclusive License Agreement (ELA) in which Relief will retain development and commercialization rights for OLPRUVA™ in the Geographical Europe, where Acer will have the right to receive a royalty of up to 10% of the net sales of OLPRUVA™.
• For additional Important Safety Information, see full Prescribing Information , Patient Package Insert and discuss with your doctor.

• This often makes it hard to pin down the spread of different contaminants throughout them.
• Our two new studies have used backyard bees to better monitor contamination in urban environments.
• Read more:
  Bees can do so much more than you think – from dancing to being little art critics

The buzz behind biomonitoring

• While foraging for nectar, pollen and water, bees are constantly picking up contaminants from their environment.
• European honey bees have long been used as sentinel species to monitor for pests and diseases, including Varroa mites and chemicals at airports.
• As the popularity of urban beekeeping has grown, there has been more research on honey bee biomonitoring of a range of contaminants, including metals, pesticides and so-called “forever chemicals”, known as PFAS, in honey.

How bees help us map pollution

• In Nouméa, we used honey bees to map impacts from the local nickel smelter.
• However, comparing the data from bees to soil and dust samples revealed bees were the most sensitive and effective marker of smelter contamination.
• By mapping trace metals in honey bees in Sydney we could look at the specific factors contributing to metal pollution within their foraging range.
• We also examined how bees can help us understand emerging concerns such as the spread of antimicrobial resistance (AMR) genes.

How do contaminants affect bees?

• Our analyses showed contaminants build up within the bee over time and were not present on their exterior.
• We compared metal concentrations in matched samples of washed and unwashed bees and they were no different, indicating contaminants were inside the bee.
• Research has shown exposure to contaminants including metals and neonicotinoid insecticides can impair honey bee development, foraging ability and survival.

And what’s in their honey?

• While we previously identified some commercial honeys are adulterated with sugar syrups, this new work focused on potentially toxic trace metals in the honey.
• The good news is we found trace metals in honey at very low levels that do not pose a concern.

Bees aren’t the only biomonitors

• The lessons from this work have led the Environment Protection Authority (EPA) Victoria, with which we are all affiliated, to explore the use of biomonitors (honey bees, house sparrows and birds of prey) in its ongoing environmental contaminant research.
• Earth is facing a multitude of interlacing environmental challenges including biodiversity loss, climate change, population growth and pervasive chemical pollution.
• More comprehensive monitoring, including surveillance using bees, will allow us to respond more quickly and effectively to environmental health challenges.