Stress ulcer

Mallinckrodt Presents Data Evaluating Acthar® Gel (Repository Corticotropin Injection) for the Treatment of Severe Keratitis at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting

Retrieved on: 
Monday, May 3, 2021

Monitor patients for effects of HPA axis suppression after stopping treatment\nCushing\'s syndrome may occur during therapy but generally resolves after therapy is stopped.

Key Points: 
  • Monitor patients for effects of HPA axis suppression after stopping treatment\nCushing\'s syndrome may occur during therapy but generally resolves after therapy is stopped.
  • Monitor patients for signs and symptoms\nActhar can cause elevation of blood pressure, salt and water retention, and hypokalemia.
  • Monitor blood pressure and sodium and potassium levels\nActhar often acts by masking symptoms of other diseases/disorders.
  • Monitor patients carefully during and for a period following discontinuation of therapy\nActhar can cause gastrointestinal (GI) bleeding and gastric ulcer.

Researchers Find Antidepressants Significantly Increase Risk of Gastrointestinal, Intracranial Bleeding

Retrieved on: 
Wednesday, January 30, 2019

However, they also carry risks for gastrointestinal and intracranial bleeding that compound when taken with other medications.

Key Points: 
  • However, they also carry risks for gastrointestinal and intracranial bleeding that compound when taken with other medications.
  • While gastrointestinal bleeding is most common, in rare instances patients can develop intracranial bleeding, which is a life-threatening event.
  • Yuet says that the risk for bleeding is well established but not well known among patients.
  • She also recommends physicians monitor their patients closely for symptoms of gastrointestinal bleeding during the first 30 days of SSRI therapy, especially if patients are taking concurrent medications that may increase bleeding risk.