Cell surface receptor

Glucagon Receptor Structures Reveal G protein Specificity Mechanism

Retrieved on: 
Thursday, March 19, 2020

This study offers valuable insights into pleiotropic GPCR-G protein coupling and G protein specificity.

Key Points: 
  • This study offers valuable insights into pleiotropic GPCR-G protein coupling and G protein specificity.
  • Although GCGR couples to both G proteins through the common pocket, it does so with different interaction patterns, which account for G protein specificity.
  • Based on the structures of GCGR-G protein complexes, the researchers performed extensive functional studies using techniques such as mutagenesis, G protein activation and cell signaling to investigate the roles of key residues in the receptor-G protein binding interface in Gs and Gi activation.
  • The results show that conformational differences of intracellular loops and residue side chains in the receptor are sufficient to guide G protein selectivity.

Glucagon Receptor Structures Reveal G protein Specificity Mechanism

Retrieved on: 
Thursday, March 19, 2020

This study offers valuable insights into pleiotropic GPCR-G protein coupling and G protein specificity.

Key Points: 
  • This study offers valuable insights into pleiotropic GPCR-G protein coupling and G protein specificity.
  • Although GCGR couples to both G proteins through the common pocket, it does so with different interaction patterns, which account for G protein specificity.
  • Based on the structures of GCGR-G protein complexes, the researchers performed extensive functional studies using techniques such as mutagenesis, G protein activation and cell signaling to investigate the roles of key residues in the receptor-G protein binding interface in Gs and Gi activation.
  • The results show that conformational differences of intracellular loops and residue side chains in the receptor are sufficient to guide G protein selectivity.

Kanazawa University Research: Scientists Successfully Obtain Synthetic Growth Factor Compatible to the Native Protein

Retrieved on: 
Tuesday, January 29, 2019

Kunio Matsumoto at Kanazawa University and colleagues have recently created a substitute for one such growth factor, that produces a comparable biological response.

Key Points: 
  • Kunio Matsumoto at Kanazawa University and colleagues have recently created a substitute for one such growth factor, that produces a comparable biological response.
  • HGF (Hepatocyte Growth Factor) is a bioactive protein which exerts biological activities through the binding and activation of the MET transmembrane receptor.
  • The University is located on the coast of the Sea of Japan in Kanazawa - a city rich in history and culture.
  • Kanazawa University is divided into two main campuses: Kakuma and Takaramachi for its approximately 10,200 students including 600 from overseas.

Kanazawa University Research: Scientists Successfully Obtain Synthetic Growth Factor Compatible to the Native Protein

Retrieved on: 
Tuesday, January 29, 2019

Kunio Matsumoto at Kanazawa University and colleagues have recently created a substitute for one such growth factor, that produces a comparable biological response.

Key Points: 
  • Kunio Matsumoto at Kanazawa University and colleagues have recently created a substitute for one such growth factor, that produces a comparable biological response.
  • HGF (Hepatocyte Growth Factor) is a bioactive protein which exerts biological activities through the binding and activation of the MET transmembrane receptor.
  • The University is located on the coast of the Sea of Japan in Kanazawa - a city rich in history and culture.
  • Kanazawa University is divided into two main campuses: Kakuma and Takaramachi for its approximately 10,200 students including 600 from overseas.