Influenza-like illness

Agios Presents Positive Results from Phase 2 Portion of the RISE UP Pivotal Study in Sickle Cell Disease at 65th ASH Annual Meeting and Exposition

Retrieved on: 
Sunday, December 10, 2023

CAMBRIDGE, Mass., Dec. 09, 2023 (GLOBE NEWSWIRE) -- Agios Pharmaceuticals, Inc. (Nasdaq: AGIO), a leader in the field of cellular metabolism pioneering therapies for rare diseases, today presented detailed results from the Phase 2 portion of the global RISE UP study of mitapivat in sickle cell disease in an oral presentation (abstract #271) at the 65th American Society of Hematology (ASH) Annual Meeting & Exposition, which is being hosted Dec. 9-12, 2023, in San Diego.

Key Points: 
  • The safety profile for mitapivat observed in the study was generally consistent with previously reported data in other studies of sickle cell disease and other hemolytic anemias.
  • Improvements were observed in annualized rates of sickle cell pain crises, and markers of hemolysis and erythropoiesis for both mitapivat treatment arms compared to placebo.
  • “Currently there are no approved oral therapies that address both sickle cell pain crises and chronic anemia, two of the hallmark symptoms of the disease.
  • Title: A Phase 2/3, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study of Mitapivat in Patients With Sickle Cell Disease: RISE UP Phase 2 Results
    Oral Abstract Session: 114.

Replimune Shares Initial Primary Analysis Results from CERPASS Clinical Trial in Advanced Cutaneous Squamous Cell Carcinoma and Presents New Data from IGNYTE Clinical Trial of RP1 in Anti-PD1 Failed Melanoma and Non-Melanoma Skin Cancers

Retrieved on: 
Tuesday, December 5, 2023

The CERPASS study was conducted under a Master Clinical Trial Collaboration and Supply Agreement with Regeneron Pharmaceuticals.

Key Points: 
  • The CERPASS study was conducted under a Master Clinical Trial Collaboration and Supply Agreement with Regeneron Pharmaceuticals.
  • The ORR was comparable between the two study groups (52.5% for RP1 plus cemiplimab vs. 51.4% for cemiplimab alone, p=0.692).
  • The registration directed anti-PD1 failed melanoma cohort from the IGNYTE clinical trial includes 140 patients and completed enrollment earlier this year.
  • RP1 monotherapy was well tolerated, and the safety profile was similar to that observed in non-immunocompromised patients with advanced skin cancers.

Illumina launches Global Health Access Initiative to support acceleration of pathogen sequencing in low- and middle-income countries

Retrieved on: 
Monday, November 13, 2023

SAN DIEGO, Nov. 13, 2023 /PRNewswire/ -- Illumina Inc. (NASDAQ: ILMN), a global leader in DNA sequencing and array-based technologies, announced today the launch of the Global Health Access Initiative to support access to pathogen sequencing tools for public health in low- and middle-income countries (LMICs). The program, developed with guidance from customers, funders, and market facilitators including the nonprofit FIND, will provide reduced pricing structures for eligible sequencing products from Illumina to qualified global health funding entities and address key international logistics and supply chain challenges.

Key Points: 
  • SAN DIEGO, Nov. 13, 2023 /PRNewswire/ -- Illumina Inc. (NASDAQ: ILMN), a global leader in DNA sequencing and array-based technologies, announced today the launch of the Global Health Access Initiative to support access to pathogen sequencing tools for public health in low- and middle-income countries (LMICs).
  • "We know that enabling countries to perform pathogen sequencing locally strengthens health systems, enables better preparedness, and empowers countries to manage their priority health threats," said Vanessa Moeder, head of Global Health at Illumina.
  • In the Illumina global team's experience, Moeder says, the countries or regions whose public health preparedness would most benefit from genomics often lack the resources to sustainably implement it.
  • The equitable access program developed and operationalized by Illumina will allow many low- and middle-income nations to participate in the future of genomics across public health and preparedness."

DHSS launches interactive statewide flu dashboard

Retrieved on: 
Friday, October 13, 2023

It is available as an interactive online dashboard , launched today.

Key Points: 
  • It is available as an interactive online dashboard , launched today.
  • The first week of this official flu season, Oct. 1-7, showed low flu activity with 125 laboratory-confirmed cases of influenza A and B reported statewide.
  • The dashboard streamlines the previous weekly flu reports , which DHSS has produced for many years during each official flu season (October through mid-May).
  • “This dashboard is another example of our continued commitment to modernizing the data we collect, analyze and share with Missourians,” said DHSS Director Paula F. Nickelson.

Who tracked UK COVID infections the best at the height of the pandemic? A new study provides the answer

Retrieved on: 
Tuesday, October 17, 2023

We wanted to know which of these methods was the most reliable during the first two years of the pandemic.

Key Points: 
  • We wanted to know which of these methods was the most reliable during the first two years of the pandemic.
  • The gold standard surveillance was the Office for National Statistics (ONS) COVID survey.
  • This data tracked the ONS estimates very closely, though the reported numbers were usually only about 45% of the ONS data.
  • The Zoe app also tracked the ONS survey estimates closely and was a good estimate of whether infections were rising or falling.
  • For COVID, the question was can wastewater testing indicate how much infection is present in the population?
  • In our analysis, we found that counts in wastewater were moderately correlated with the prevalence of COVID in the population.

Useful additional insights

    • Even so, the other approaches provided useful additional insights.
    • NHS 111 call and website data provided useful information early in the pandemic, before other surveillance methods were established.
    • Although wastewater surveillance did little to increase our understanding of the course of the pandemic in England, this surveillance method may be useful in countries that don’t have easy access to human testing.

Insilico Medicine announces positive topline results of the New Zealand Phase 1 trial of INS018_055, an AI-designed drug for an AI-discovered target

Retrieved on: 
Tuesday, January 10, 2023

Enrollment in Insilico Medicine’s Phase 1 clinical trial was initiated in Feb. 2022 and the last subject follow-up visit was completed in Nov. 2022.

Key Points: 
  • Enrollment in Insilico Medicine’s Phase 1 clinical trial was initiated in Feb. 2022 and the last subject follow-up visit was completed in Nov. 2022.
  • Based on these results, Insilico expects to initiate a Phase 2a study of INS018_055 in IPF patients in early 2023.
  • The positive Phase I data enable the further evaluation of the drug efficacy in IPF patients in the Phase 2 trial.
  • In addition, the continued progression of INS018_055 demonstrates again the power of our AI platform in drug discovery and development.”

ESO launches Public Health Resource Center to Share Prehospital and Hospital Outcome Data Related to COVID-19, Influenza and Respiratory Syncytial Virus (RSV)

Retrieved on: 
Thursday, December 8, 2022

The Resource Center is designed to share relevant information and data insights regarding 911 calls associated with COVID-19, influenza-like illness, and RSV.

Key Points: 
  • The Resource Center is designed to share relevant information and data insights regarding 911 calls associated with COVID-19, influenza-like illness, and RSV.
  • We are seeing a rise in 911 calls connected to severe flu and respiratory illnesses, said Dr. Brent Myers, Chief Medical Officer for ESO.
  • The data for the Public Health Resource Center comes from the ESO Data Collaborative consisting of more than 2,000 EMS agencies across the United States.
  • ESO (ESO Solutions, Inc.) is dedicated to improving community health and safety through the power of data.

Evidation Launches FluSmart, A Direct-to-Person Digital Flu Monitoring Program, To Better Understand Flu in Everyday Life

Retrieved on: 
Wednesday, October 26, 2022

Evidation, the company that connects directly with individuals to measure health in everyday life, has launched FluSmart, a digital flu monitoring program that brings together individuals, researchers, and public and private organizations to understand flu at its earliest stages.

Key Points: 
  • Evidation, the company that connects directly with individuals to measure health in everyday life, has launched FluSmart, a digital flu monitoring program that brings together individuals, researchers, and public and private organizations to understand flu at its earliest stages.
  • View the full release here: https://www.businesswire.com/news/home/20221026005641/en/
    Evidations FluSmart is a nationwide program that helps people proactively understand risk factors for flu and provides personalized insights related to flu and influenza-like illness.
  • Individuals can report flu symptoms at any time and do not need a wearable to participate in the program.
  • Evidation has developed machine learning detection models to compare flu and COVID and validated and extended this work with collaborators .

CSL Seqirus to Highlight Commitment to Influenza Protection with More than 20 Data Presentations at OPTIONS XI

Retrieved on: 
Tuesday, September 13, 2022

Data derived from a broad range of seasonal and pandemic influenza studies, including an oral presentation of influenza risk factors, will be shared.

Key Points: 
  • Data derived from a broad range of seasonal and pandemic influenza studies, including an oral presentation of influenza risk factors, will be shared.
  • "At CSL Seqirus, vaccine innovation is in our DNA, which is reflected in our strong presence at OPTIONS XI," said S. Raja Rajaram, M.D., Head of Global Medical Strategy, CSL Seqirus.
  • Cost-Effectiveness of Quadrivalent Adjuvanted Influenza Vaccine with MF59 Versus a Standard-Dose Quadrivalent Influenza Vaccines in Spain.
  • Today, CSL including our three businesses, CSL Behring, CSL Seqirus and CSL Vifor provides lifesaving products to patients in more than 100 countries and employs 30,000 people.

LumiraDx COVID-19 & Flu A/B Rapid Antigen Test Achieves CE Marking

Retrieved on: 
Thursday, December 23, 2021

LONDON, Dec. 23, 2021 /PRNewswire/ --LumiraDx (Nasdaq: LMDX), a next-generation point of care diagnostics company, today announced its SARS-CoV-2& Flu A/BAntigen Test has achieved CE Marking.

Key Points: 
  • LONDON, Dec. 23, 2021 /PRNewswire/ --LumiraDx (Nasdaq: LMDX), a next-generation point of care diagnostics company, today announced its SARS-CoV-2& Flu A/BAntigen Test has achieved CE Marking.
  • Existing respiratory tests on the LumiraDx Platform include the company's SARS-CoV-2 Antigen, SARS-CoV-2 Antibody and SARS-CoV-2 Antigen Pool tests which achieved CE Marking in August 2020, September 2020 and March 2021, respectively.
  • Shipments of the LumiraDx SARS-CoV-2 & Flu A/B Antigen Test will begin shortly.
  • Private Securities Litigation Reform Act of 1995, including statements regarding the performance and benefits of the SARS-CoV-2 & Flu A/B Antigen Test.