Typhoid fever

From sumptuous engravings to stick-figure sketches, Passover Haggadahs − and their art − have been evolving for centuries

Retrieved on: 
Friday, April 19, 2024

The Jewish festival of Passover recalls the biblical story of the Israelites enslaved by Egypt and their miraculous escape.

Key Points: 
  • The Jewish festival of Passover recalls the biblical story of the Israelites enslaved by Egypt and their miraculous escape.
  • Every year, a written guide known as a “Haggadah” is read at the Seder table.
  • The core text comprises a description of ritual foods, the story of the Exodus, blessings, commentaries, hymns and songs.

An illustrated classic


One of the greatest examples our library has of this blending of cultures was printed in Amsterdam in 1695.

  • The Amsterdam Haggadah was illustrated by Abraham Bar Yaakov, a German pastor who converted to Judaism.
  • In addition, he incorporated a pull-out map of the route of the Exodus and an imaginative rendering of the Temple in Jerusalem.
  • The text, traditionally written in Hebrew and Aramaic, included instructions in Yiddish and Ladino, the everyday languages for Jews in Europe.
  • The Amsterdam Haggadah proved to be incredibly influential on later versions, with its illustrations copied into the modern era.

A Haggadah for everyone

  • Modern Haggadah illustrations also reflected developments in the art world.
  • In 1920s Berlin, a Jewish art teacher, Otto Geismar, reinterpreted the story of the Exodus using plain, black-and-white, modernist “stick figures” – another Haggadah in our collection.
  • Geismar even injected elements of humor: A child is shown asleep at the table, and in another scene a family of stick figures is engaged in animated conversation and debate.
  • In his depictions of ancient Israelite slaves, stick figures appear especially burdened with heavy loads on their backs.

Wine – and coffee

  • Meanwhile, some suppliers sensed an opportunity to adapt it for their own needs.
  • Owner Sam Schapiro savvily linked his products to the Seder, during which participants drink four small cups of sacramental wine.
  • Wine, seen at this point as a luxury item, also symbolized freedom.
  • Schapiro’s Haggadah fulfilled the commandment to relate the story of the Exodus for a new generation – but the opening pages also provide a tribute in Yiddish to Sam Schapiro’s 40-year-old company.
  • Here Schapiro’s is praised for being the place where religious men and intellectuals alike could get together over a good glass of wine.


Rebecca J.W. Jefferson does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

New International Samaritan partnership takes Trinity Health doctors and residents to Ethiopia

Retrieved on: 
Tuesday, February 6, 2024

ANN ARBOR, Mich., Feb. 6, 2024 /PRNewswire/ -- In a new partnership with International Samaritan, a select group of Trinity Health doctors and residents will be traveling to care for patients at a hospital in Addis Ababa, the capital city of Ethiopia, as part of the Trinity Health Ann Arbor residency program.

Key Points: 
  • ANN ARBOR, Mich., Feb. 6, 2024 /PRNewswire/ -- In a new partnership with International Samaritan, a select group of Trinity Health doctors and residents will be traveling to care for patients at a hospital in Addis Ababa, the capital city of Ethiopia, as part of the Trinity Health Ann Arbor residency program.
  • A team of Trinity Health doctors traveled with International Samaritan to Addis Ababa this past October to visit the area and explore the idea of a partnership for Trinity Health residents.
  • Along with working at Alert Hospital, during their rotation, the Trinity Health physicians and residents will spend a day caring for the people that International Samaritan works with.
  • "Sixty International Samaritan families underwent comprehensive check-ups when three generous doctors from Trinity Health visited last October," said Selam Kahsay, International Samaritan's Health and Wellness Specialist in Ethiopia.

‘We miners die a lot.’ Appalling conditions and poverty wages: the lives of cobalt miners in the DRC

Retrieved on: 
Tuesday, January 30, 2024

Estimates suggest that as many as 11,000 men and women work on the site, the majority of whom have no other means of deriving a livelihood.

Key Points: 
  • Estimates suggest that as many as 11,000 men and women work on the site, the majority of whom have no other means of deriving a livelihood.
  • Risking their lives, they tunnel deep into the red earth, excavating cobalt in shafts that descend as deep as 100 metres, and yet they receive almost none of the profits.
  • This story of labour exploitation and unequal exchange in Africa has become an all-too-familiar one to me.
  • I was eager to visit the site because I had heard many encouraging things about it.
  • Most artisanal mining sites are found in remote locations, remain unplanned and unregulated, and are subject to a host of social and environmental problems.
  • But at the same time, there has been much fanfare around the idea of organising artisanal miners into cooperatives, as a potential solution to this problem.
  • The team is working with academics from different backgrounds who have been engaged in projects aimed at tackling societal and scientific challenges.
  • There are people who come from Kasai, the Chinese who leave China to come here, Canadians who leave their country to come here.
  • It is very good.

‘The work we do is hard’

  • Many told me they only started mining because they wanted to create a better life for their kids.
  • It is easy to understand why a parent would tolerate hardship, injustice and risk, if it could help their children.
  • We only do this work because we don’t have the means to survive.
  • The work we do is hard because it’s a job you do all day long.
  • We only do this work because we don’t have the means to survive.

‘We miners die a lot’

  • Six miners were killed and the depth and design of the tunnels meant that the bodies could not be recovered.
  • And to be sure, all the miners I spoke to feared such a disaster could happen to them at any time.
  • Death and injury is common among artisanal miners, due to both tunnel collapses and working without personal protective equipment.
  • We miners die a lot.
  • We miners die a lot.

Toxic dust and birth defects

  • Further compounding the hazardous working conditions, cobalt dust is toxic, affecting all those working in mines, but also those in the wider community.
  • That research also found high concentrations of uranium in the urine of exposed children and miners.
  • A Lancet study found that pregnant women living in cobalt-mining communities have the highest levels ever reported of heavy metals in their blood.
  • The same study demonstrated a five-fold increase in risk of birth defects in babies born to fathers working in cobalt mines.
  • Alphonsine, eloquently described the horrific conditions that washers must endure:
    There are several problems in doing this work.
  • Recent comparisons of time-lapse satellite imagery over the past five years demonstrates the dramatic growth of cobalt mines in and around Kolwezi.

The invisible face of the cobalt rush

  • Hunting for the buried blue treasure – a key ingredient in the lithium-ion batteries used in consumer electronics and electric vehicles that are vital to global efforts to combat climate change – artisanal miners like Ghislain have long been the invisible face of the cobalt rush.
  • The Congolese cobalt rush fuels a multi-billion-dollar industry for international mining companies and buying agents – often from China – that have moved into the country.
  • Southern Congo sits upon 3.4 million tons of cobalt, an estimated two thirds of the world’s known supply.
  • Alphonsine told me that she didn’t know what happened to the cobalt she washed, after it left the site.
  • Instead of buying well so that we too can win, they buy the products maliciously.
  • As the world transitions to electric vehicles, competition over supplies of cobalt continues to intensify, with global demand set to increase up to eight-fold by 2040.
  • Against this backdrop, the OECD estimates that there are more than 200,000 creuseurs, often labouring alongside large-scale industrial operations, who extract up to 30% of Congo’s cobalt.

Child labour

  • Such claims have provided fertile ground for a high-profile legal case against the world’s largest tech companies, launched in December 2019 by Congolese families, over deaths and serious injuries sustained by child labourers in cobalt mines.
  • In October 2022, the US Department of Labour added lithium-ion batteries to its list of goods produced by child labour.

No such thing as ‘clean cobalt’

  • Profit margins are much higher when it’s possible to purchase cobalt that is extracted under slave-like conditions.
  • And the reality is that cobalt unearthed by creuseurs is bought by agents and processed alongside cobalt from large-scale mines, with over 80% of it then being refined in China.
  • As things stand, there is no such thing as “clean cobalt”.

Plausible deniability


While the negative impacts of the cobalt boom may be increasingly visible and have now become impossible to ignore, industry is not held accountable, partially because it has found new ways to hide its exploitative business practices.

  • Complexity in the supply chain helps big corporations to demand profit-boosting efficiencies at arms’ length, giving them plausible deniability for the consequences of their actions.
  • These companies also have become adept at spinning their purported efforts to improve conditions.
  • Look at their websites and you’ll probably see a massive section devoted to sustainability and community-building.


For you: more from our Insights series:
Mr Bates vs The Post Office depicts one of the UK’s worst miscarriages of justice: here’s why so many victims didn’t speak out

Victims of the green energy boom? The Indonesians facing eviction over a China-backed plan to turn their island into a solar panel ‘ecocity’

Unlocking new clues to how dementia and Alzheimer’s work in the brain – Uncharted Brain podcast series

To hear about new Insights articles, join the hundreds of thousands of people who value The Conversation’s evidence-based news. Subscribe to our newsletter.
For this research, Roy Maconachie received funding from the Global Challenge Research Fund (GCRF), the Bath Research in Development (BRID) Fund, and the Bath Impact Fund.

SK bioscience and Vaxxas Enter Joint Development Agreement for Needle-Free Patch Delivery of Typhoid Vaccine

Retrieved on: 
Thursday, August 24, 2023

SK bioscience and Vaxxas have officially entered into a Joint Development Agreement.

Key Points: 
  • SK bioscience and Vaxxas have officially entered into a Joint Development Agreement.
  • This collaboration is set to revolutionize vaccine delivery by developing a novel vaccine-delivery device combination product using Vaxxas' high-density microarray patch (HD-MAP) platform technology with SK bioscience's proprietary typhoid vaccine.
  • Under the agreement, SK bioscience will supply the antigen utilized by its typhoid conjugate vaccine, SKYTyhpoid™ that was jointly developed by SK bioscience and the International Vaccine Institute (IVI).
  • SK bioscience collaborated with Wellcome and the IVI on the development of a trivalent invasive non-typhoidal Salmonellosis vaccine candidate in 2019.

Vaxxas Awarded US$3.67 million (AU$5.4 million) from global charitable foundation, Wellcome, for Human Clinical Study of Typhoid Vaccination using Needle-Free Vaccine Patch

Retrieved on: 
Thursday, August 24, 2023

The typhoid vaccine formulation used to coat the HD-MAP will be based on SKYTyhpoid™, an approved typhoid conjugate vaccine that was jointly developed by Vaxxas’ collaborator in this project, SK bioscience, and the International Vaccine Institute (IVI).

Key Points: 
  • The typhoid vaccine formulation used to coat the HD-MAP will be based on SKYTyhpoid™, an approved typhoid conjugate vaccine that was jointly developed by Vaxxas’ collaborator in this project, SK bioscience, and the International Vaccine Institute (IVI).
  • The typhoid vaccine product candidate used in these studies will be formulated to be more stable at higher temperatures than required for needle and syringe vaccination.
  • As such, success in this endeavor has the potential to increase global access to the life-saving typhoid vaccine.
  • This project continues to build on the progress of its HD-MAP technology in human clinical studies with other vaccine candidates including COVID-19 and influenza.

'He was horrific!': Nearly two thirds of family historians are distressed by what they find – should DNA kits come with warnings?

Retrieved on: 
Tuesday, June 27, 2023

I’m not the only one to have experienced intense emotions – both negative and positive – while researching my forebears.

Key Points: 
  • I’m not the only one to have experienced intense emotions – both negative and positive – while researching my forebears.
  • My recent research revealed about two thirds of family historians have experienced strong negative emotions like sorrow or anger through their hobby.

Passionate ‘kin keepers’

    • In 2019, Doreen Rosenthal and I surveyed 775 Australian hobbyist family historians to examine their motivations.
    • They were adults aged between 21 and 93, but most were older and the median age was 63.
    • Survey respondents described why they were passionately engaged with their hobby – and how it made them feel.

1. Ancestors behaving badly

    • The first and most common distress trigger was the discovery of ancestors who had behaved badly – either as individuals, or by profiting from unjust social conditions.
    • And:
      [It was] difficult finding that ancestors may have been involved in unsavoury behaviours or events.
    • [It was] difficult finding that ancestors may have been involved in unsavoury behaviours or events.

2. Ancestors treated cruelly

    • It was also distressing to discover ancestors who had been cruelly treated.
    • Many were deeply moved by what their ancestors experienced.

3. Sad stories

    • Women commonly did not survive childbirth, neonatal deaths were frequent, people died of diseases medical science has now conquered.
    • [It is distressing] to uncover particularly sad and desperate times in some ancestors’ lives.
    • [It is distressing] to uncover particularly sad and desperate times in some ancestors’ lives.

4. Family secrets and betrayal

    • The fourth distress trigger was a belief by the family history researcher that they had been betrayed by other family members: through secrets, lies and feeling their lived experience was ignored or denied.
    • If family members can lie about these important things, what else might they lie about?
    • Read more:
      We used DNA from Beethoven's hair to shed light on his poor health – and stumbled upon a family secret

5. Moral dilemmas

    • Finally, several respondents expressed doubt and confusion at the moral dilemmas they faced on discovering information that could greatly distress other living relatives.
    • An emotional burden attaches to withholding potentially distressing information of this kind.
    • Yet there is also guilt and fear about the possible outcomes of sharing it.
    • Read more:
      Friday essay: how do I understand who I am, when my family have hidden themselves from recent history?

Healthy outcomes from bad feelings

    • Sometimes these distressing feelings can promote healthy, growth-enhancing outcomes.
    • Initial feelings of distress about past injustices and tragedies are sometimes replaced by admiration for the strength and resilience of one’s forebears.

How can family and professionals help?

    • I processed my great great grandmother’s story by writing it down and sharing it with family members.
    • We reworked our sadness at her fate into a positive family narrative, emphasising her bravery and the strengths her surviving children showed.
    • Support can mean just disclosing these stories to family members, friends and other family historians.

Emergent BioSolutions Announces Sale of Travel Health Business to Bavarian Nordic for Up To $380 Million

Retrieved on: 
Wednesday, February 15, 2023

Bavarian Nordic will also acquire Emergent’s manufacturing site in Bern, Switzerland, and development facilities in San Diego, California.

Key Points: 
  • Bavarian Nordic will also acquire Emergent’s manufacturing site in Bern, Switzerland, and development facilities in San Diego, California.
  • Approximately 280 current Emergent employees are expected to join Bavarian Nordic as part of the transaction.
  • Upon closing of the transaction, Bavarian Nordic will pay Emergent $270 million in upfront cash consideration.
  • For Emergent BioSolutions, Wells Fargo Securities, LLC served as financial advisor, and Barnes & Thornburg LLP served as legal counsel for this transaction.

Bavarian Nordic to Acquire Portfolio of Travel Vaccines from Emergent BioSolutions

Retrieved on: 
Wednesday, February 15, 2023

A late-stage vaccine candidate targeting Chikungunya with expected Phase 3 read-out in the second half of 2023 and projected launch in 2025.

Key Points: 
  • A late-stage vaccine candidate targeting Chikungunya with expected Phase 3 read-out in the second half of 2023 and projected launch in 2025.
  • Travel vaccines are seeing a rebound after the COVID-19 pandemic and the expanded portfolio allows us to further explore synergies in our commercial presence across key markets.
  • There are currently no approved vaccines against Chikungunya, which analysts estimate could represent an annual market worth more than USD 500 million.
  • The management of Bavarian Nordic will host an investor/analyst call today, February 15, 2023, at 2 pm CET (8 am EST) to discuss the acquisition.

Travel Vaccine Global Market Report 2022: Stringent Advisories and Regulations by Health Authorities to Aid Growth - ResearchAndMarkets.com

Retrieved on: 
Thursday, December 1, 2022

The global travel vaccine market is anticipated to grow at a steady rate in the forecast period, 2023-2027.

Key Points: 
  • The global travel vaccine market is anticipated to grow at a steady rate in the forecast period, 2023-2027.
  • The market growth can be attributed to the rising incidences of flu and rapid growth in the travel and tourism sector.
  • Travel vaccines, also known as travel immunizations, are vaccine shots that protect travelers from serious illnesses.
  • Increasing regulations for safe traveling are supporting the normalization of travel vaccines among travelers, which is expected to boost the market growth.

Indonesia Diagnostic Labs Market Report 2022: Growing Healthcare Expenditure Fueling Sector Growth - ResearchAndMarkets.com

Retrieved on: 
Wednesday, October 5, 2022

The "Indonesia Diagnostic Labs Market, By Provider Type (Hospital Based Diagnostic Labs, Diagnostic Chains, Stand Alone Diagnostic Labs), By Test Type (Pathology v/s Radiology), By End User, By Region, Competition, Forecast & Opportunities, 2017-2027F" report has been added to ResearchAndMarkets.com's offering.

Key Points: 
  • The "Indonesia Diagnostic Labs Market, By Provider Type (Hospital Based Diagnostic Labs, Diagnostic Chains, Stand Alone Diagnostic Labs), By Test Type (Pathology v/s Radiology), By End User, By Region, Competition, Forecast & Opportunities, 2017-2027F" report has been added to ResearchAndMarkets.com's offering.
  • Indonesia diagnostic labs market stood at USD 1,997.95 Million in 2021 and is expected to reach a CAGR of 7.84% during the forecast period.
  • Additionally, the growing geriatric population is susceptible to various diseases and requires regular diagnostic checkups for disease diagnosis and treatment, increasing the demand for diagnostic labs.
  • This, in turn, is expected to create lucrative opportunities for the growth of the Indonesia diagnostic labs market during the forecast period.