CSHL

Why some RNA drugs work better than others

Retrieved on: 
Wednesday, March 6, 2024
Infant, Research, Drug development, Krainer, SMA, RNA, Risdiplam, Genome, Patient, SPRING, Pancreatic cancer, Cold Spring Harbor Laboratory, RNA splicing, CSHL, Vaccine

CSHL Associate Professor Justin Kinney, Krainer, and postdoc Yuma Ishigami have figured out why some splicing-based drugs tend to work better than others.

Key Points: 
  • CSHL Associate Professor Justin Kinney, Krainer, and postdoc Yuma Ishigami have figured out why some splicing-based drugs tend to work better than others.
  • To better understand how this drug works, the Kinney and Krainer labs analyzed risdiplam's interactions with RNA.
  • "Our new study provides insights into the action and specificity of splice-modifying drugs," Krainer says.
  • "This should facilitate the development of more effective drugs and drug combinations for a variety of diseases."

These worms have rhythm

Retrieved on: 
Wednesday, December 27, 2023
Cold Spring Harbor Laboratory, CSHL, Music, Protein, Mir-17 microRNA precursor family, SPRING, HHMI, Human, Brain, Pulse, Calculus, Cancer, Animal, Behavior, Gene expression, Curie Institute, Hammel (surname)

COLD SPRING HARBOR, N.Y., Dec. 27, 2023 /PRNewswire/ -- There's a rhythm to developing life.

Key Points: 
  • COLD SPRING HARBOR, N.Y., Dec. 27, 2023 /PRNewswire/ -- There's a rhythm to developing life.
  • Losing the rhythm can lead to diseases like cancer.
  • Cold Spring Harbor Laboratory (CSHL) Professor Christopher Hammell has found that in the worm C. elegans, this genetic orchestra has no single conductor.
  • Understanding how the worm's clock is regulated could help explain how time affects development in other animals.

Can we crack this cancer's immune response?

Retrieved on: 
Wednesday, November 29, 2023
Cold Spring Harbor Laboratory, Pancreatic cancer, Immunity, Antigen, Immune system, Cold, Pancreatic tumor, CSHL, Disease, B cell, Vaccination, Patient, Cancer, PDAC, Northwell Health, Pancreas, Future, Antibody, SPRING, Cell, Vaccine

It's thought patients do not show a natural immune response to the cancer because the tumor environment somehow prevents that response.

Key Points: 
  • It's thought patients do not show a natural immune response to the cancer because the tumor environment somehow prevents that response.
  • Many are unconvinced that PDAC interacts with the immune system at all.
  • CSHL scientists have now confirmed that pancreatic cancer does trigger a response in our immune system.
  • The idea was that the synthetic antibodies would point the team toward the new PDAC antigen behind the body's immune response .

18th Double Helix Medals dinner raises more than $10 million

Retrieved on: 
Monday, November 27, 2023
Cold Spring Harbor Laboratory, Invention, Renal cell carcinoma, Perception, DRS, Research, Howard Hughes Corporation, Double Helix Medal, CSHL, Medicine, Pershing Square Capital Management, Nobel Prize, Summa Corporation, MD Anderson Cancer Center, FDA, Immunotherapy, CBS, Lung cancer, Cancer, Natural history, Ipilimumab, Rivka Oxman, Entomology, American Museum, Museum, SPRING, Environment, Biology, Education, Pharmaceutical industry, Physiology

COLD SPRING HARBOR, N.Y., Nov. 27, 2023 /PRNewswire/ -- On November 15, Cold Spring Harbor Laboratory (CSHL) held its 18th annual Double Helix Medals dinner (DHMD) at the American Museum of Natural History in New York City.

Key Points: 
  • COLD SPRING HARBOR, N.Y., Nov. 27, 2023 /PRNewswire/ -- On November 15, Cold Spring Harbor Laboratory (CSHL) held its 18th annual Double Helix Medals dinner (DHMD) at the American Museum of Natural History in New York City.
  • CBS journalist Lesley Stahl returned to emcee the awards dinner, which honored Neri Oxman & William Ackman and 2018 Nobel laureate Jim Allison.
  • After receiving the Double Helix Medal, Oxman and Ackman announced an extraordinary gift, further breaking the event's fundraising record to support scientific research and education at CSHL.
  • Since the inaugural gala in 2006 honoring Muhammed Ali, the DHMD has raised over $60 million to support CSHL's biological research and education programs.

Cold Spring Harbor Laboratory rolls out STEM 'Bicycle Principles'

Retrieved on: 
Tuesday, November 21, 2023
Assistant, Dolan DNA Learning Center, Data management, STEM, DNA, Engineering, Mathematics, Cold, CSHL, Cold Spring Harbor Laboratory, Learning, Research, Science, University, Intercultural communication principles, Diversity, AI, SPRING, Meeting, Education, Nursing, Management

COLD SPRING HARBOR, N.Y., Nov. 21, 2023 /PRNewswire/ -- Success in science, technology, engineering, and mathematics (STEM) demands keeping up with the latest tools and techniques.

Key Points: 
  • COLD SPRING HARBOR, N.Y., Nov. 21, 2023 /PRNewswire/ -- Success in science, technology, engineering, and mathematics (STEM) demands keeping up with the latest tools and techniques.
  • Short training programs like webinars and boot camps have become a popular alternative among busy STEM professionals.
  • There's often no guarantee attendees will leave with the skills needed to advance their careers.
  • Williams is Assistant Director of Diversity and Research Readiness at the Cold Spring Harbor Laboratory (CSHL) DNA Learning Center .

You say genome editing, I say natural mutation

Retrieved on: 
Wednesday, November 8, 2023
Domestication, Human, CRISPR, Genetics, McCandlish, Cold Spring Harbor Laboratory, Nature, Computational biology, Learning, SPRING, CSHL, Genome, HHMI, Probability, Gene, Cold, Associate, Mutation

COLD SPRING HARBOR, N.Y., Nov. 8, 2023 /PRNewswire/ -- For tens of thousands of years, evolution shaped tomatoes through natural mutations .

Key Points: 
  • COLD SPRING HARBOR, N.Y., Nov. 8, 2023 /PRNewswire/ -- For tens of thousands of years, evolution shaped tomatoes through natural mutations .
  • Today, CRISPR genome editing allows us to make new crop mutations that improve traits even further.
  • And what if just one could dramatically alter the desired outcome of an engineered mutation?
  • (Natural mutation of this gene is known to increase fruit size.)

Smells like learning

Retrieved on: 
Tuesday, October 31, 2023
Flower, Neuron, Salk Institute for Biological Studies, Glass, Cold Spring Harbor Laboratory, Research, Cell, Mouse, CSHL, Learning, SPRING, Computer, Animal, Citrus, Brain, Srinivas, Wine, Associate, Aroma compound

They have found that certain neurons allow fruit flies and mice to tell apart distinct smells.

Key Points: 
  • They have found that certain neurons allow fruit flies and mice to tell apart distinct smells.
  • Next, the team observed that some neurons respond differently to two very dissimilar odors, but the same to similar smells.
  • Another much larger group of neurons responds unpredictably when exposed to similar smells.
  • In more continual learning systems, variability could be useful."

Metastatic breast cancer's Trojan horse

Retrieved on: 
Wednesday, July 26, 2023
Breast cancer classification, Therapy, Cancer, Research, Lymph, Assistant, Cancer of unknown primary origin, SPRING, Beyaz, CSHL, MHC-II, Immune system, Coffee, Mouse, Hospital, Cold Spring Harbor Laboratory, Lymph node, Massachusetts General Hospital, Metastasis, Breast cancer, Disease, Vaccine, Medical imaging, Dietary supplement

But somehow, lymph nodes are also the first stop for most metastatic cancers.

Key Points: 
  • But somehow, lymph nodes are also the first stop for most metastatic cancers.
  • They found that breast cancer cells trick the immune system with help from a molecule called MHC-II.
  • "For example, in the gut, we see the opposite of what's happening in breast cancer," Beyaz explains.
  • Over 300,000 people in the U.S. will be diagnosed with breast cancer this year alone.

The latest weapon against cancer is … a keto diet?

Retrieved on: 
Monday, June 12, 2023
Mouse, Cachexia, Neoplasm, Glucose, Weight loss, Cancer, Ferroptosis, Nutrient, Research, Hercules, Assistant, COLD, Death, Metabolism, Patient, CSHL, Divorce, Cold Spring Harbor Laboratory, Human, Fatigue, Disease, Dietary supplement, Pharmaceutical industry, Trapping

COLD SPRING HARBOR, N.Y., June 12, 2023 /PRNewswire/ -- Dietitians say a keto diet could help you lose up to 10% of your body weight. These high-fat, low-carb meal plans trick the body into burning its own fat. They could also help fight a variety of cancers by starving tumors of the glucose they need to grow. On the surface, this seems ideal. But research suggests these diets may have a deadly, unintended side effect for cancer patients.

Key Points: 
  • In mice with pancreatic and colorectal cancer , keto accelerates a lethal wasting disease called cachexia.
  • Janowitz and Ferrer are part of an international Cancer Grand Challenges effort taking on cancer cachexia .
  • The team is now working to fine-tune corticosteroid timing and dosage to widen the window for effective cancer therapies in combination with keto.
  • "If we can broaden this effect, make the treatment more efficient, we can ultimately benefit patients and improve cancer therapeutics.

Ellen V. Futter elected Cold Spring Harbor Laboratory Trustee

Retrieved on: 
Friday, June 9, 2023
Memorial Sloan Kettering Cancer Center, Federal Reserve Bank, Rose Center, IRS, Brookings Institution, Innovation, Barnard College, Cold, SPRING, Cold Spring Harbor Laboratory, CSHL, Natural history, American Museum, Entomology, Consolidated Edison, Education, Management, Trustee

COLD SPRING HARBOR, N.Y., June 9, 2023 /PRNewswire/ -- On June 8, 2023, the Cold Spring Harbor Laboratory (CSHL) Board of Trustees elected Ellen V. Futter to the private not-for-profit institution's governing body.

Key Points: 
  • COLD SPRING HARBOR, N.Y., June 9, 2023 /PRNewswire/ -- On June 8, 2023, the Cold Spring Harbor Laboratory (CSHL) Board of Trustees elected Ellen V. Futter to the private not-for-profit institution's governing body.
  • Futter is the president emerita of the American Museum of Natural History.
  • Futter has been a nationally recognized academic leader since 1980, when, at age 30, she was named president of Barnard College.
  • At the time, Futter was the youngest person to hold that position at a major American college.