Leibniz Association

• This discovery represents one of the first new classes of antibiotics in the past 60 years and is the first discovered leveraging an AI-powered platform built around explainable deep learning.
• Researchers at Integrated Biosciences have discovered the first-ever class of antibiotics identified using a new and explainable artificial intelligence.
• In their study, the researchers virtually screened more than 12 million candidate compounds to identify this new class of antibiotics.
• The publication, “Discovery of a structural class of antibiotics with explainable deep learning,” can be accessed on the Nature website at: https://www.nature.com/articles/s41586-023-06887-8 .

• The Luftbrücke license, in the Frankfurt region, includes a number of large industrial areas including the Höchst Chemical Park, and Frankfurt Airport, which are all heavy energy consumers requiring large quantities of renewable energy and heating solutions.
• It is also very carbon intensive, with almost 80% fossil energy sources, mainly gas and coal.
• Given Frankfurt’s high heat demand, there is a significant commercial and decarbonisation opportunity for Vulcan Energy via geothermal renewable energy development in Luftbrücke.
• “This new licence signifies a major future phase opportunity for Vulcan as a dual lithium and geothermal energy producer,” said Managing Director and CEO Cris Moreno.

• With the death of last male in 2018 and with only two females alive, the species is functionally extinct.
• In one of its research lines, the BioRescue team collects mature eggs – scientifically called oocytes – from one of the only two northern white females.
• These eggs will be fertilised with frozen sperm that were collected from several northern white male rhinos before their death.
• These techniques would not only save the northern white rhinoceros, but also other rhino species, related species with a common ancestor, and all other creatures in need.

Different approaches

• Parallel initiatives focusing on different conservation approaches are indispensable to ensure the future of this species.
• These supporting cells provide signals and components essential for the development of the eggs.
• This would bypass atresia, which is the degradation of follicles that occurs during a natural hormonal cycle.
• Due to a scarcity of tissues from endangered species, we are using the pig as a large animal model.
• This will give us more in-depth knowledge on how to approach egg creation from stem cells already present in the animal, termed endogenous stem cells.

What next?

• Researchers now know that samples of the northern white rhino individuals currently stored in biobanks have enough genetic variability to establish a viable and sustainable population.
• This is becoming a reality that gives us hope, motivation and energy to save the northern white rhino.

• The Leibniz Institute for Financial Research SAFE and the Securitisation Repository European DataWarehouse (EDW) have been awarded a grant from the German Federal Ministry for Education and Research under the Climate Protection and Finance (KlimFi) funding initiative to undertake a three-year project for the promotion of the green auto asset-backed securities (ABS) market.
• Operating as a market infrastructure, EDW aims to increase transparency and restore confidence in the ABS market.
• Through EDW's data, users can analyze underlying portfolios in a more efficient way and compare portfolios on a systematic basis.
• For the latest updates from European DataWarehouse, follow us on LinkedIn or visit our websites www.eurodw.eu / www.eurodw.co.uk
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