Sonic hedgehog

Senhwa's Silmitasertib Receives US FDA Orphan Drug Designation for the Treatment of Biliary Tract Cancer

Retrieved on: 
Thursday, January 20, 2022

"We are pleased to receive ODD for Silmitasertib for the treatment of Biliary Tract Cancer, a rare, malignant disease for which there are no effective therapies.

Key Points: 
  • "We are pleased to receive ODD for Silmitasertib for the treatment of Biliary Tract Cancer, a rare, malignant disease for which there are no effective therapies.
  • Biliary tract cancer (BTC) refers to a group of rare, diverse and aggressive cancers that arise from the bile duct system.
  • BTCs are classified into four distinct subtypes based on the tissue where the cancer originates including intrahepatic cholangiocarcinoma (IHCC), extrahepatic cholangiocarcinoma (EHCC), gallbladder cancer (GBC) and ampullary cancer.
  • The US FDA has granted Silmitasertib key drug designations: Orphan Drug Designation for the treatment of Cholangiocarcinoma inDecember 2016, Rare Pediatric Disease Designation and Orphan Drug Designation for the treatment of Medulloblastoma inJuly 2020and December 2021, respectively.Fast Track Designation was granted inAugust 2021for the treatment of recurrent Sonic Hedgehog driven Medulloblastoma.

StemSynergy Therapeutics’ Notch1-Selective Small Molecule Inhibitor Prevents Tumor Growth by Ablation of Cancer Stem Cells

Retrieved on: 
Wednesday, April 14, 2021

StemSynergy Therapeutics, Inc., who collaborated on this study holds worldwide exclusivity to develop these molecules for the clinic.\n"The Notch pathway is an extremely attractive target for cancer therapeutics, as it is a critical driver of many human cancers.

Key Points: 
  • StemSynergy Therapeutics, Inc., who collaborated on this study holds worldwide exclusivity to develop these molecules for the clinic.\n"The Notch pathway is an extremely attractive target for cancer therapeutics, as it is a critical driver of many human cancers.
  • "Specifically, NADI-351 clears cancer stem cells by starving them of Notch signaling and causes cell death in tumors, including esophageal and triple-negative breast cancer.
  • At the same time this breakthrough science is being published, StemSynergy Therapeutics is developing this class of compound for clinical evaluation.
  • Our mission is to optimize efficacy against the pathways required to drive cancer stem cells, such as the Wnt, Sonic Hedgehog and Notch signaling pathways.

UPDATE: ECO INNOVATION GROUP Announces LOI for Steel and Hemp Homes Joint Venture in Santa Barbara County

Retrieved on: 
Thursday, October 10, 2019

ECO Innovation Group is pleased to announce that it has entered an LOI to establish its West Coast base of operations for the companys wholly owned construction subsidiary, Steel Hemp Homes Inc (SHH), in Santa Barbara County, California.

Key Points: 
  • ECO Innovation Group is pleased to announce that it has entered an LOI to establish its West Coast base of operations for the companys wholly owned construction subsidiary, Steel Hemp Homes Inc (SHH), in Santa Barbara County, California.
  • ECOx / SHH will address the affordability and catastrophe resiliency issues in California with a unique steel and industrial hemp-based construction system.
  • ECOx will initially introduce a more affordable, fire, earthquake, hurricane and flood resilient steel framing system importantly complemented by carbon negative industrial hemp building materials.
  • The Company intends to rapidly scale to address the global need for more affordable, resilient and sustainable housing and construction generally.

ECO INNOVATION GROUP Announces LOI for Steel and Hemp Homes Joint Venture in Santa Barbara County

Retrieved on: 
Thursday, October 10, 2019

ECO Innovation Group is pleased to announce that it has entered an LOI to establish its West Coast base of operations for the companys wholly owned construction subsidiary, Steel Hemp Homes Inc (SHH), in Santa Barbara County, California.

Key Points: 
  • ECO Innovation Group is pleased to announce that it has entered an LOI to establish its West Coast base of operations for the companys wholly owned construction subsidiary, Steel Hemp Homes Inc (SHH), in Santa Barbara County, California.
  • ECOx / SHH will address the affordability and catastrophe resiliency issues in California with a unique steel and industrial hemp-based construction system.
  • ECOx will initially introduce a more affordable, fire, earthquake, hurricane and flood resilient steel framing system importantly complemented by carbon negative industrial hemp building materials.
  • The Company intends to rapidly scale to address the global need for more affordable, resilient and sustainable housing and construction generally.

From Simple Reversing Alarms to Cameras and Radars – Brigade Electronics Explains How the Vehicle Safety Industry has Developed

Retrieved on: 
Monday, September 24, 2018

Research has found that 25% of all deaths in the workplace are caused by reversing vehicles.

Key Points: 
  • Research has found that 25% of all deaths in the workplace are caused by reversing vehicles.
  • These days, ever more sophisticated technology is being introduced by safety experts to address this issue and save lives.
  • Following research carried out by Brigade Electronics , a white noise multi-frequency alarm was developed in the early 2000s, emitting a 'shh-shh' sound rather than 'beep-beep'.
  • Radars complete the vehicle safety picture, detecting people and objects in a driver's blind spot, not covered by mirrors.