Glutamate carboxypeptidase II

Two New Studies to Explore Telix Assets in Breast Cancer Theranostics

Retrieved on: 
Wednesday, August 18, 2021

Both TLX591-CDx and TLX250-CDx have potential utility in breast cancer imaging, particularly for specific phenotypes that are not consistently well imaged using existing techniques.

Key Points: 
  • Both TLX591-CDx and TLX250-CDx have potential utility in breast cancer imaging, particularly for specific phenotypes that are not consistently well imaged using existing techniques.
  • Breast Cancer is the most commonly occurring cancer in women and the second most common cancer overall.7 In 2020, over 2.2 million women were diagnosed with breast cancer and 685,000 died from their disease.8
    Lobular breast cancer (also called invasive lobular carcinoma) is atype of breast cancerthat begins in the milk-producing glands (lobules) of the breast.
  • It is the second most common type of breast cancer, accounting for 10-15% of all invasive breast cancers.
  • Triple-negative breast cancer accounts for 10-15% of all breast cancers with the term triple-negative referring to the fact that the cancer cells do not have any of the three markers commonly found on breast cancer cells the oestrogen and progesterone receptors and HER2 protein.

Harpoon Therapeutics Reports Second Quarter 2021 Financial Results and Provides Corporate Update

Retrieved on: 
Thursday, August 5, 2021

SOUTH SAN FRANCISCO, Calif., Aug. 05, 2021 (GLOBE NEWSWIRE) -- Harpoon Therapeutics, Inc. (Nasdaq: HARP), a clinical-stage immunotherapy company developing a novel class of T cell engagers, today reported financial results for the second quarter ended June 30, 2021 and provided a corporate update.

Key Points: 
  • SOUTH SAN FRANCISCO, Calif., Aug. 05, 2021 (GLOBE NEWSWIRE) -- Harpoon Therapeutics, Inc. (Nasdaq: HARP), a clinical-stage immunotherapy company developing a novel class of T cell engagers, today reported financial results for the second quarter ended June 30, 2021 and provided a corporate update.
  • In June 2021, Harpoon provided a corporate pipeline update.
  • Revenue for the second quarter ended June 30, 2021 was $5.8 million compared to $2.8 million for the quarter ended June 30, 2020.
  • Net loss for the second quarter ended June 30, 2021 was $16.8 million compared to $12.7 million for the quarter ended June 30, 2020.

Pre-clinical data on HOOKIPA’s arenaviral immunotherapeutic in melanoma published in Nature Communications

Retrieved on: 
Thursday, August 5, 2021

The data demonstrate that HOOKIPAs LCMV-based vector, designed to target melanoma, modulated the tumor microenvironment and induced potent, tumor antigen-specific T cell responses, resulting in tumor regression and tumor cures in a pre-clinical setting.

Key Points: 
  • The data demonstrate that HOOKIPAs LCMV-based vector, designed to target melanoma, modulated the tumor microenvironment and induced potent, tumor antigen-specific T cell responses, resulting in tumor regression and tumor cures in a pre-clinical setting.
  • The pre-clinical data published in Nature Communications add to the growing body of evidence on our arenaviral therapeutics ability to induce potent T cell responses and drive tumor regression and, in many cases, tumor cures, said Joern Aldag, Chief Executive Officer at HOOKIPA.
  • Were pleased to see parallels in significant T cell responses, even after a single administration, between these data in melanoma and the HPV data weve reported in both pre-clinical and clinical settings.
  • HOOKIPAs HB-300 program for prostate cancer also uses the LCMV and PICV arenaviral backbones directed against three validated antigens for prostate cancer: PAP, PSA, and PSMA.

First Patient Dosed in CUPID Study of Telix’s Targeted Alpha Therapy Candidate for Prostate Cancer

Retrieved on: 
Wednesday, August 4, 2021

MELBOURNE, Australia, Aug. 04, 2021 (GLOBE NEWSWIRE) -- Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company) announces today that the first patient has been dosed in its CUPID first-in-human Phase I study of the Companys next generation prostate cancer therapy candidate TLX592 in patients with advanced prostate cancer.

Key Points: 
  • MELBOURNE, Australia, Aug. 04, 2021 (GLOBE NEWSWIRE) -- Telix Pharmaceuticals Limited (ASX: TLX, Telix, the Company) announces today that the first patient has been dosed in its CUPID first-in-human Phase I study of the Companys next generation prostate cancer therapy candidate TLX592 in patients with advanced prostate cancer.
  • This investigational agent will become Telixs first targeted alpha therapy (TAT) for the treatment of patients with advanced prostate cancer.
  • TLX592 targets prostate specific membrane antigen (PSMA)1, as does the Companys existing TLX591 (177Lu-rosapatamab) prostate cancer therapy program.
  • The very high energy, short range properties of targeted alpha therapy have the potential to offer a potent and highly selective anti-cancer therapy to patients with advanced prostate cancer.

Excel Diagnostics and Nuclear Oncology Center Announces FDA Authorization of IND for 225Ac-PSMA I&T Targeted Alpha Therapy for Castration Resistant Prostate Cancer

Retrieved on: 
Wednesday, August 4, 2021

Houston, TX, Aug. 04, 2021 (GLOBE NEWSWIRE) -- Excel Diagnostics and Nuclear Oncology Center (EDNOC), a premier Diagnostic Imaging and Radioligand Therapy center in Houston, Texas announces approval of its physicians sponsored Investigational New Drug (IND) application for providing Targeted Alpha Therapy (TAT) with 225Ac-PSMA I&T for metastatic Castration-Resistant Prostate Cancer (mCRPC).

Key Points: 
  • Houston, TX, Aug. 04, 2021 (GLOBE NEWSWIRE) -- Excel Diagnostics and Nuclear Oncology Center (EDNOC), a premier Diagnostic Imaging and Radioligand Therapy center in Houston, Texas announces approval of its physicians sponsored Investigational New Drug (IND) application for providing Targeted Alpha Therapy (TAT) with 225Ac-PSMA I&T for metastatic Castration-Resistant Prostate Cancer (mCRPC).
  • Excel Diagnostics and Nuclear Oncology Center has been a pioneer in bringing new targeted Radioligand Therapies such as Lu-177 DOTATATE, and Lu-177 PSMA to serve our patients in the United States.
  • Highly encouraging results have been reported by using Targeted Alpha Therapy (TAT) Radiopharmaceuticals in conditions such as neuroendocrine, prostate, or hematological malignancies.
  • In April of 2020, Excel passed FDA inspection of one of its investigational drugs with no deficiencies or citations.

Ambrx Announces First Patient Dosed in a Phase 1 Trial for ARX517, an ADC in Development to Treat PSMA Expressing Tumors

Retrieved on: 
Tuesday, August 3, 2021

The Phase 1 trial will be a multi-center, open-label, dose escalation and dose expansion study.

Key Points: 
  • The Phase 1 trial will be a multi-center, open-label, dose escalation and dose expansion study.
  • The trial will enroll up to 76 patients with advanced solid tumors whose diseases have failed prior standard therapies.
  • While non-ADC therapies are available to treat mCRPC, there is no approved therapy specifically targeting PSMA to treat prostate cancer.
  • Ambrx undertakes no duty or obligation to update any forward-looking statements contained in this press release as a result of new information.

Lantheus Announces the First and Only FDA Cleared AI-Enabled PSMA Digital Application, aPROMISE™, Strengthening Lantheus’ Leadership in Prostate Cancer

Retrieved on: 
Thursday, July 29, 2021

A negative image does not rule out the presence of prostate cancer and a positive image does not confirm the presence of prostate cancer.

Key Points: 
  • A negative image does not rule out the presence of prostate cancer and a positive image does not confirm the presence of prostate cancer.
  • PYLARIFY uptake is not specific for prostate cancer and may occur with other types of cancer as well as non-malignant processes and in normal tissues.
  • aPROMISE: A Novel Automated-PROMISE platform to Standardize Evaluation of Tumor Burden in (18)F-DCFPyL (PSMA) images of Veterans with Prostate Cancer.
  • PSMA PET for primary lymph node staging of intermediate and high-risk prostate cancer: an expedited systematic review.

Cancer Targeted Technology Receives Milestone Payment for Development of Diagnostic PET Imaging Agent for Prostate Cancer

Retrieved on: 
Tuesday, June 29, 2021

Cancer Targeted Technology (CTT), a privately held Seattle-based biotechnology company, received a milestone payment from Advanced Accelerator Applications International S.A. (AAA), a Novartis company, triggered by the upcoming clinical trials of investigational 18F-CTT1057, a diagnostic PET imaging agent for prostate cancer.

Key Points: 
  • Cancer Targeted Technology (CTT), a privately held Seattle-based biotechnology company, received a milestone payment from Advanced Accelerator Applications International S.A. (AAA), a Novartis company, triggered by the upcoming clinical trials of investigational 18F-CTT1057, a diagnostic PET imaging agent for prostate cancer.
  • CTT1057 targets the biomarker, Prostate Specific Membrane Antigen (PSMA), which is over-expressed on most prostate cancer cells.
  • Prior to licensing, CTT completed prostate cancer clinical trials of CTT1057 in adult males at University of California, San Francisco (UCSF), with encouraging safety and imaging results.
  • Features that make the phosphoramidate PSMA-binding scaffold unique include irreversible binding to PSMA and excellent uptake by PSMA-expressing tumor cells.

Lantheus To Present Piflufolastat F 18 Data at the Virtual Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2021 Annual Meeting

Retrieved on: 
Monday, June 14, 2021

A negative image does not rule out the presence of prostate cancer and a positive image does not confirm the presence of prostate cancer.

Key Points: 
  • A negative image does not rule out the presence of prostate cancer and a positive image does not confirm the presence of prostate cancer.
  • The performance of PYLARIFY for imaging of patients with biochemical evidence of recurrence of prostate cancer seems to be affected by serum PSA levels.
  • 18 F-DCFPyL PET/CT Imaging in Patients with Biochemically Recurrent Prostate Cancer After Primary Local Therapy J Nucl Med 2020 Jun;61(6):881-889. doi: 10.2967/jnumed.119.234799.
  • 3Werner et al 18F-Labeled, PSMA-Targeted Radiotracers: Leveraging the Advantages of Radiofluorination for Prostate Cancer Molecular Imaging Theranostics 2020; 10(1):1-16. doi:10.7150/thno.37894.

Bayer Acquires Noria and PSMA Therapeutics to Expand Pipeline in Prostate Cancer

Retrieved on: 
Thursday, June 3, 2021

Bayer today announced that it has entered into an agreement to acquire Noria Therapeutics Inc. (Noria) and PSMA Therapeutics Inc.

Key Points: 
  • Bayer today announced that it has entered into an agreement to acquire Noria Therapeutics Inc. (Noria) and PSMA Therapeutics Inc.
  • Prostate cancer is the second most commonly diagnosed cancer in men1 and a key area of focus for Bayer.
  • About Noria Therapeutics (Noria) / PSMA Therapeutics Inc.
    Noria is a research and development company managed by experienced radiopharmaceutical development leaders and focused on the development of novel targeted alpha therapeutics and theranostic agents.
  • PSMA Therapeutics Inc. is a subsidiary of Noria to advance the platform of prostate-specific membrane antigen (PSMA) targeting radiotherapeutics.