Manure

Draft guideline on good agricultural and collection practice (GACP) for starting materials of herbal origin - Revision 1

Retrieved on: 
Thursday, April 18, 2024
Reproduction, SCOPE, Eating, Pesticide, Convention, Change control, Confusion, Alkaloid, Climate, Fungus, Directive (European Union), Ethylene oxide, Wind, Wood, Glass, European Medicines Agency, HMPS, QDG, Hygiene, Water, Marketing, Fertilizer, Legislation, Manure, Distillation, Risk, Education, Committee, Compost, Draft, Policy, Person, EMA, Seed, Polycyclic aromatic hydrocarbon, Collection, Freezing, GMP, Risk assessment, GACP, Sunlight, Fermentation, Personal protective equipment, Animal, Herbal, Herbicide, Weather, INTRODUCTION, Documentation, Regeneration, Decontamination, EudraLex, Disease, International trade, European Pharmacopoeia, Part, Livestock, Public, Inhalation, Knowledge, Seedling, Factorization of polynomials, Record, Plant, Skin, API, Irrigation, Part Two, Soil, Directive, Pharmacopoeia, Codex, Guideline, Temperature, Attention, Hydrocarbon, Pyrrolizidine alkaloid, Polychlorinated biphenyl, Growth, Rotation, Incineration, Environment, Humidity, Smell, Ventilation, Light, Bird, Mineral, Fumigation, Pyrrolizidine, SOP, Housing, Smoking, Atmosphere, Postharvest, Rain, Liver, QWP, Medicinal plants

REFERENCES ....................................................................................................................................... 14

Key Points: 
    • REFERENCES ....................................................................................................................................... 14

      29

      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 3/14

      30

      EXECUTIVE SUMMARY

      31
      32
      33
      34
      35
      36

      This guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin

      37

      1.

    • Due to the inherent
      complexity of medicinal plants and herbal substances the quality of these starting materials requires an
      adequate quality assurance system for the collection and/or cultivation, harvest, and primary
      processing.
    • (either outdoor, indoor or in greenhouses) should be carefully considered, since each of the mentioned
      types could have several problems and advantages.
    • The used cultivation method may be dependent on
      the final application of the herbal medicinal product.
    • primary processing of herbal substances that are used for the preparation of herbal medicinal products.
    • medicinal plants and herbal substances, ensuring that they are handled appropriately throughout all
      stages of cultivation, collection, processing and storage.
    • their preparations are exposed to a large number of environmental contaminants of both biotic and
      abiotic origin.
    • to existing wildlife habitats and must adhere to CITES (Convention on International Trade in
      Endangered species of Wild Fauna and Flora).
    • https://health.ec.europa.eu/document/download/bd537ccf-9271-4230-bca1-2d...
      4 https://health.ec.europa.eu/document/download/fd318dd6-2404-4e67-82b0232...
      3

      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 5/14

      104

      4.

    • Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 6/14

      147
      148
      149

      8.

    • Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 7/14

      185

      7.

    • Where possible, stable varieties and cultivars naturally
      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 8/14

      227
      228

      resistant or tolerant to disease should preferably be used.

    • Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 9/14

      268
      269
      270
      271
      272
      273

      The application should be carried out only by qualified staff using approved equipment.

    • The following should be noted:

      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 10/14

      309
      310

      ?

      311
      312
      313

      ?

      314
      315
      316
      317

      ?

      318
      319
      320

      ?

      321
      322

      ?

      323
      324
      325

      ?

      326
      327
      328

      ?

      Damaged plants or plant parts need to be excluded or limited in accordance with a specific
      pharmacopoeia monograph, where relevant.

    • Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 11/14

      347
      348

      directly to the sun (except in cases where there is a specific need) and must be protected from
      rainfall, insect infestation, etc.

    • The label must be clear, permanently fixed and made from

      6

      Reflection paper on the use of fumigants (EMEA/HMPC/125562/2006)

      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 12/14

      386
      387

      non-toxic material.

    • Certain exudates that have not been subjected to a specific treatment are

      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 13/14

      425
      426
      427

      also considered to be herbal substances.

    • European Pharmacopoeia General Monograph ?HERBAL DRUGS? 07/2017:1433

      Are obtained by subjecting herbal substances to treatments such as
      extraction, distillation, expression, fractionation, purification, concentration
      or fermentation.

Draft guideline on good agricultural and collection practice (GACP) for starting materials of herbal origin - Revision 1

Retrieved on: 
Thursday, April 18, 2024
Reproduction, SCOPE, Eating, Pesticide, Convention, Change control, Confusion, Alkaloid, Climate, Fungus, Directive (European Union), Ethylene oxide, Wind, Wood, Glass, European Medicines Agency, HMPS, QDG, Hygiene, Water, Marketing, Fertilizer, Legislation, Manure, Distillation, Risk, Education, Committee, Compost, Draft, Policy, Person, EMA, Seed, Polycyclic aromatic hydrocarbon, Collection, Freezing, GMP, Risk assessment, GACP, Sunlight, Fermentation, Personal protective equipment, Animal, Herbal, Herbicide, Weather, INTRODUCTION, Documentation, Regeneration, Decontamination, EudraLex, Disease, International trade, European Pharmacopoeia, Part, Livestock, Public, Inhalation, Knowledge, Seedling, Factorization of polynomials, Record, Plant, Skin, API, Irrigation, Part Two, Soil, Directive, Pharmacopoeia, Codex, Guideline, Temperature, Attention, Hydrocarbon, Pyrrolizidine alkaloid, Polychlorinated biphenyl, Growth, Rotation, Incineration, Environment, Humidity, Smell, Ventilation, Light, Bird, Mineral, Fumigation, Pyrrolizidine, SOP, Housing, Smoking, Atmosphere, Postharvest, Rain, Liver, QWP, Medicinal plants

REFERENCES ....................................................................................................................................... 14

Key Points: 
    • REFERENCES ....................................................................................................................................... 14

      29

      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 3/14

      30

      EXECUTIVE SUMMARY

      31
      32
      33
      34
      35
      36

      This guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin

      37

      1.

    • Due to the inherent
      complexity of medicinal plants and herbal substances the quality of these starting materials requires an
      adequate quality assurance system for the collection and/or cultivation, harvest, and primary
      processing.
    • (either outdoor, indoor or in greenhouses) should be carefully considered, since each of the mentioned
      types could have several problems and advantages.
    • The used cultivation method may be dependent on
      the final application of the herbal medicinal product.
    • primary processing of herbal substances that are used for the preparation of herbal medicinal products.
    • medicinal plants and herbal substances, ensuring that they are handled appropriately throughout all
      stages of cultivation, collection, processing and storage.
    • their preparations are exposed to a large number of environmental contaminants of both biotic and
      abiotic origin.
    • to existing wildlife habitats and must adhere to CITES (Convention on International Trade in
      Endangered species of Wild Fauna and Flora).
    • https://health.ec.europa.eu/document/download/bd537ccf-9271-4230-bca1-2d...
      4 https://health.ec.europa.eu/document/download/fd318dd6-2404-4e67-82b0232...
      3

      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 5/14

      104

      4.

    • Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 6/14

      147
      148
      149

      8.

    • Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 7/14

      185

      7.

    • Where possible, stable varieties and cultivars naturally
      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 8/14

      227
      228

      resistant or tolerant to disease should preferably be used.

    • Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 9/14

      268
      269
      270
      271
      272
      273

      The application should be carried out only by qualified staff using approved equipment.

    • The following should be noted:

      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 10/14

      309
      310

      ?

      311
      312
      313

      ?

      314
      315
      316
      317

      ?

      318
      319
      320

      ?

      321
      322

      ?

      323
      324
      325

      ?

      326
      327
      328

      ?

      Damaged plants or plant parts need to be excluded or limited in accordance with a specific
      pharmacopoeia monograph, where relevant.

    • Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 11/14

      347
      348

      directly to the sun (except in cases where there is a specific need) and must be protected from
      rainfall, insect infestation, etc.

    • The label must be clear, permanently fixed and made from

      6

      Reflection paper on the use of fumigants (EMEA/HMPC/125562/2006)

      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 12/14

      386
      387

      non-toxic material.

    • Certain exudates that have not been subjected to a specific treatment are

      Guideline on Good Agricultural and Collection Practice (GACP) for starting materials of herbal origin
      EMA/HMPC/246816/2005

      Page 13/14

      425
      426
      427

      also considered to be herbal substances.

    • European Pharmacopoeia General Monograph ?HERBAL DRUGS? 07/2017:1433

      Are obtained by subjecting herbal substances to treatments such as
      extraction, distillation, expression, fractionation, purification, concentration
      or fermentation.

Waste Management Market worth $1598.1 billion by 2029 - Exclusive Report by MarketsandMarkets™

Retrieved on: 
Monday, April 8, 2024
Single, Biodegradable waste, Agricultural waste, Glass, Metal, Investment, Restaurant, Republic Services, Hook, Wood, Combustion, Waste management, Food industry, Compost, Developing country, PS, Region, Municipal solid waste, Electricity, PVC, Industrial waste, Hazardous waste, Plastic, L.L.C, Demolition, Mining, Construction, Manure, Environment, Digestion, PET, PP, Process, Collection, Government, Recycling

Based on waste type, the Waste Management Market is categorized into six categories: Hazardous Waste, E-Waste, Municipal Solid Waste, Medical Waste, Construction & Demolition, Non-Hazardous Industrial waste.

Key Points: 
  • Based on waste type, the Waste Management Market is categorized into six categories: Hazardous Waste, E-Waste, Municipal Solid Waste, Medical Waste, Construction & Demolition, Non-Hazardous Industrial waste.
  • Developing countries like China see a rise in industrial waste generation, while countries like India witness increasing demand for waste management services.
  • In North America, the waste management sector benefits from efficient industrial waste management techniques, an increasing focus on environmental cleanliness, and the primary industrial sectors such as electricity, pharmaceuticals, and oil and gas, which are major consumers of waste management services.
  • (US), Suez (France), Veolia (France), Republic Services (US) & Waste Connections (US) are the market leaders in the Waste Management Market.

Waste Management Market worth $1598.1 billion by 2029 - Exclusive Report by MarketsandMarkets™

Retrieved on: 
Monday, April 8, 2024
Single, Biodegradable waste, Agricultural waste, Glass, Metal, Investment, Restaurant, Republic Services, Hook, Wood, Combustion, Waste management, Food industry, Compost, Developing country, PS, Region, Municipal solid waste, Electricity, PVC, Industrial waste, Hazardous waste, Plastic, L.L.C, Demolition, Mining, Construction, Manure, Environment, Digestion, PET, PP, Process, Collection, Government, Recycling

Based on waste type, the Waste Management Market is categorized into six categories: Hazardous Waste, E-Waste, Municipal Solid Waste, Medical Waste, Construction & Demolition, Non-Hazardous Industrial waste.

Key Points: 
  • Based on waste type, the Waste Management Market is categorized into six categories: Hazardous Waste, E-Waste, Municipal Solid Waste, Medical Waste, Construction & Demolition, Non-Hazardous Industrial waste.
  • Developing countries like China see a rise in industrial waste generation, while countries like India witness increasing demand for waste management services.
  • In North America, the waste management sector benefits from efficient industrial waste management techniques, an increasing focus on environmental cleanliness, and the primary industrial sectors such as electricity, pharmaceuticals, and oil and gas, which are major consumers of waste management services.
  • (US), Suez (France), Veolia (France), Republic Services (US) & Waste Connections (US) are the market leaders in the Waste Management Market.

Vanguard Renewables Celebrates a Decade of Clean Energy Innovation

Retrieved on: 
Wednesday, March 13, 2024
Agriculture, Natural Resources, Environment, Alternative Energy, Energy, Food, Beverage, Green Technology, Retail, Dairy Farmers of America, Natural gas, Farm, Manure, AstraZeneca, University, Incineration, Science, Recycling, Partnership, Vanguard, Carbon, Eye, Host, Workforce, Starbucks, Engineering, RNG, Digestion, Renewable energy

Vanguard Renewables®, a farm-based provider of organic material solutions for the food and beverage industry, is celebrating a decade in clean energy innovation and organic materials solutions.

Key Points: 
  • Vanguard Renewables®, a farm-based provider of organic material solutions for the food and beverage industry, is celebrating a decade in clean energy innovation and organic materials solutions.
  • As part of its aggressive growth strategy, Vanguard Renewables is developing multiple Farm Powered® digesters across the country that will service almost every major metropolitan market.
  • “When we launched Vanguard Renewables in 2014, I was researching why something that had been so successful in Europe had not been replicated in the United States,” stated John Hanselman, Chief Strategy Officer at Vanguard Renewables.
  • With a team of dedicated solutions providers, world-class scientists and engineers, strong leadership, and dedicated institutional partners Vanguard Renewables is well-positioned to drive the adoption of renewable energy solutions across the country for the next decade and beyond.

Celebrating Excellence: 11 Women Mavericks and Makers Shaping the Future of Temecula Valley Tourism

Retrieved on: 
Wednesday, March 27, 2024
Olive, Travel, Stampede, Commerce, Wine, Love, Fine Artist, The New Inn, Horse, Education, Woman, Loire Valley, Barn, Mt. San Jacinto College, Farm, Longevity, Manure, Wine Country, Sleep, Front Street, Interior design, Student, Women's History Month, Drink, Map, Farmer, Transport, Olive oil, Breakfast, Heart, Music, Tourism

TEMECULA, Calif., March 27, 2024 /PRNewswire-PRWeb/ -- Women's History Month is an ideal time to celebrate the phenomenal women who have made a positive impact on Temecula Valley tourism. From business owners, to chefs, to hoteliers/innkeepers, these powerful, inspiring women have contributed to Temecula's reputation as a "hidden gem" in Southern California and played key roles in putting this vibrant travel destination on the map.

Key Points: 
  • TEMECULA, Calif., March 27, 2024 /PRNewswire-PRWeb/ -- Women's History Month is an ideal time to celebrate the phenomenal women who have made a positive impact on Temecula Valley tourism.
  • "These dynamic, passionate women are shaping our destination and encouraging others to experience our beautiful Valley," said Scott A. Wilson, President & CEO, Visit Temecula Valley.
  • "These dynamic and passionate women are shaping our destination and encouraging others to experience our beautiful Valley," said Scott A. Wilson, CEO, Visit Temecula Valley.
  • "They are boldly paving the way for other women in tourism while making a positive impact on the community.

Soil Amendments Market Projected to Reach $33.47 billion by 2030 - Exclusive Report by 360iResearch

Retrieved on: 
Tuesday, March 26, 2024
Soil, Health, Climate change, Farmer, Drainage, Growth, Manure, Potassium, Agriculture, Nitrogen, Intelligence, Common, Research, Inorganic compound, Bayer, UPL, Food security, Fertility, Water purification, CAP, Carbon, Mineral, Biodiversity, Yara International, Phosphorus, Table

Soil amendments have gained importance for their pivotal role in mitigating climate change by maintaining soil health.

Key Points: 
  • Soil amendments have gained importance for their pivotal role in mitigating climate change by maintaining soil health.
  • Innovations and advancements are anticipated to refine soil amendments' effectiveness and environmental compatibility, promising tailor-made solutions based on specific soil conditions and crop necessities.
  • We proudly unveil ThinkMi, a cutting-edge AI product designed to transform how businesses interact with the Soil Amendments Market.
  • "Dive into the Soil Amendments Market Landscape: Explore 193 Pages of Insights, 928 Tables, and 28 Figures"

Soil Amendments Market Projected to Reach $33.47 billion by 2030 - Exclusive Report by 360iResearch

Retrieved on: 
Tuesday, March 26, 2024
Soil, Health, Climate change, Farmer, Drainage, Growth, Manure, Potassium, Agriculture, Nitrogen, Intelligence, Common, Research, Inorganic compound, Bayer, UPL, Food security, Fertility, Water purification, CAP, Carbon, Mineral, Biodiversity, Yara International, Phosphorus, Table

Soil amendments have gained importance for their pivotal role in mitigating climate change by maintaining soil health.

Key Points: 
  • Soil amendments have gained importance for their pivotal role in mitigating climate change by maintaining soil health.
  • Innovations and advancements are anticipated to refine soil amendments' effectiveness and environmental compatibility, promising tailor-made solutions based on specific soil conditions and crop necessities.
  • We proudly unveil ThinkMi, a cutting-edge AI product designed to transform how businesses interact with the Soil Amendments Market.
  • "Dive into the Soil Amendments Market Landscape: Explore 193 Pages of Insights, 928 Tables, and 28 Figures"

ZwitterCo Named to Fast Company's Annual List of the World's Most Innovative Companies of 2024

Retrieved on: 
Tuesday, March 19, 2024
Editorial, Culture, Climate change, Organization, Manure, MIC, Tyson Foods, Partnership, Heel, Research, EN, AI, Hope, Taco Bell, Zwitterion, ITunes, Most, Water, Food industry

BOSTON, March 19, 2024 /PRNewswire/ -- ZwitterCo, the advanced membrane technology company, has been named to Fast Company's prestigious list of the World's Most Innovative Companies of 2024.

Key Points: 
  • ZwitterCo joins the ranks of Nvidia, YouTube, Taco Bell, and more
    BOSTON, March 19, 2024 /PRNewswire/ -- ZwitterCo, the advanced membrane technology company, has been named to Fast Company's prestigious list of the World's Most Innovative Companies of 2024.
  • Alongside the World's 50 Most Innovative Companies, Fast Company recognizes 606 organizations across 58 sectors and regions.
  • "We are honored to be included among the progressive companies confronting the climate crisis," said Alex Rappaport, co-founder and CEO of ZwitterCo.
  • This event celebrates the Most Innovative Companies honorees and provides an inside look at cutting-edge business trends and what it takes to innovate in 2024.

IVECO to supply 178 sustainable trucks to DHL in Germany

Retrieved on: 
Thursday, February 29, 2024
IDV, ASTRA, IVECO, Post, Carbon, Compressed natural gas, DHL, Iveco, EXM, CNG, CO2, IVG, Natural gas, FPT Industrial, Agriculture, Manure, Propane

IVECO, the brand of Iveco Group (EXM: IVG) that designs, manufactures and markets light, medium and heavy commercial vehicles, has received an order for the supply of 178 S-Way CNG (Compressed Natural Gas) trucks to the Post & Parcel Germany division of DHL.

Key Points: 
  • IVECO, the brand of Iveco Group (EXM: IVG) that designs, manufactures and markets light, medium and heavy commercial vehicles, has received an order for the supply of 178 S-Way CNG (Compressed Natural Gas) trucks to the Post & Parcel Germany division of DHL.
  • The order will expand DHL's sustainable fleet, furthering their commitment to reducing their carbon footprint and contributing to the decarbonisation of road transport.
  • The new trucks will be primarily used for inter-hub transport at DHL parcel centres, customer pick-ups, and urban deliveries to post offices.
  • The IVECO S-Way CNG trucks are equipped with Cursor engines from FPT Industrial – the Iveco Group brand specialised in low-environmental impact powertrains – that can be powered by bio-CNG.