Prostaglandin

• Efficient drug delivery into bones remains a barrier in developing treatments for diseases of bone.
• The bone is a complex, dynamic tissue with unique properties that make it a formidable challenge for drug efficient penetration.
• The company successfully dosed the first patients via subcutaneous injection in a Phase 1 study evaluating MES1022, a bone-selective EP4 receptor agonist prodrug they are developing for bone regeneration, with the first application for accelerating healing of bone fractures.
• “MES1022 is well-positioned to be the first therapy that mimics and enhances the natural processes the body uses to stimulate bone repair and healing.

• Danco remains confident in the safety and effectiveness of Mifeprex® under the 2023 REMS that currently governs its use.
• The changes in 2016 and 2021—approved by FDA after careful analysis—have expanded the availability and use of Mifeprex®, providing crucial individual and public health benefits.
• Serious and sometimes fatal infections and bleeding occur very rarely following spontaneous, surgical, and medical abortions, including following MIFEPREX use.
• The frequency of adverse reactions varies between studies and may be dependent on many factors including the patient population and gestational age.

• In most cases, pain and fever relief is as simple as a trip to your local supermarket for some paracetamol or ibuprofen.
• Nurofen is the common brand name for ibuprofen, which is also sold under generic brand names.

Different blocking actions

• While ibuprofen and paracetamol can be taken for similar reasons (pain relief) each works in a slightly different way.
• Ibuprofen is a non-steroidal anti-inflammatory drug, which means it acts by blocking the enzymes that produce a group of chemicals called prostaglandins.
• Like ibuprofen, it is thought to act by blocking the enzymes that produce prostaglandins, although through a different mechanism to ibuprofen.

Is one drug better than the other?

• Because they each provide pain relief in different ways, paracetamol can be better at treating some types of pain, while ibuprofen is better at treating other types.
• But be wary of packaging that claims a medication is useful for targeting pain associated with a specific condition as these claims are not true.
• Paracetamol does not reduce inflammation but it is a better choice when fever is associated with the pain, like when you have a cold or flu.

What about taking both or ‘piggybacking’ them at intervals?

• If one pathway does not completely control the pain then it can be useful to target the other one.
• Combination products that contain both paracetamol and ibuprofen in a single tablet include Nuromol and Maxigesic.
• This keeps the levels of the medication in the body more constant and helps to provide more steady pain relief.
• Read more:
  Take care with paracetamol when pregnant — but don't let pain or fever go unchecked

How do the side effects compare?

• These can manifest as nausea, indigestion, bleeding in the stomach, and diarrhoea.
• For this reason, people with a history of bleeding or ulcers in the gut should not take ibuprofen.
• However, you need to be careful when using these medicines to make sure you don’t use more than is recommended.
• Read more:
  The TGA is considering paracetamol restrictions due to poisonings – but what does that mean for consumers?

Both work, both need to be used safely

• Always read the label so you know exactly what products you are using and how much.
• Only take the recommended dose, and if you need to, write down the time you take each dose.
• Your pharmacist or doctor can also advise on the best medicine for your pain and fever and how to use the selected medicine safely.

• The administrative stay issued today stops Judge Kacsmaryk's order for the time necessary for the Supreme Court to rule on the requests for a full stay.
• The administrative stay means that the approved status of Mifeprex remains unchanged, including the 2023 revisions to the REMS that allow for dispensing from certified pharmacies and by mail.
• "It is temporary, but we look forward to the careful consideration we know the Court will give to these important issues.
• "  Because of the Court's administrative stay, Mifeprex remains approved for use through 70 days' gestation and with the dosing regimen approved in 2016.