Sherlock

The Exorcist: Believer is a ‘retcon’ film - it imagines none of the sequels exist. This sequel shouldn’t exist, either

Retrieved on: 
Tuesday, October 17, 2023

Alongside the tenth Saw film, there is The Exorcist: Believer, directed by David Gordon Green, the sixth Exorcist film and the first instalment of a new trilogy which cost US$400 million in worldwide rights alone.

Key Points: 
  • Alongside the tenth Saw film, there is The Exorcist: Believer, directed by David Gordon Green, the sixth Exorcist film and the first instalment of a new trilogy which cost US$400 million in worldwide rights alone.
  • Believer follows certain rules and conventions with roots in William Peter Blatty’s bestselling 1971 novel: think demonic possession, projectile vomiting and spinning heads.
  • Believer is a “retcon”, an example of retroactive continuity: a movie which ignores or re-imagines events in previous films.

Retconning the classics

    • He was also behind the Halloween trilogy (2018–22), drawing on the 1978 film of the same name.
    • The 2018 Halloween made over US$250 million at the global box office and breathed new commercial life into a desiccated corpse of a franchise.
    • Green’s slasher picks up after the first Halloween left off, with scream queen Jamie Lee Curtis reprising her role as Laurie Strode.
    • The same, sadly, cannot be said of the two cinematic bombs that followed.)

A pale rehash

    • In keeping with other legacy sequels, both Halloween and Believer rely on hefty doses of celluloid gravitas and pre-existing star power.
    • Where the 2018 Halloween had Curtis as a damaged, alcoholic Laurie, the 2023 Exorcist has the 90-year-old Ellen Burstyn returning as Chris MacNeil.
    • In Believer, Chris, who has written a bestselling memoir about Regan’s possession, is now a leading authority on demonology.
    • If this sounds more or less like a pale rehash of Friedkin’s Exorcist, that is because it pretty much is.

‘Microwave-reheated comfort food’

    • It is very difficult to care about films of this sort, the cinematic equivalent of, in Fisher’s memorable phrase, “microwave-reheated comfort food”.
    • Had he lived long enough, I imagine Friedkin’s head would have been left swivelling at the horror of it all.
    • Read more:
      The Exorcist Believer: a real priest on why the film is 'potentially dangerous'

8 Key Trends in the $106 Billion Worldwide IVD Market

Retrieved on: 
Thursday, August 31, 2023

ARLINGTON, Va., Aug. 31, 2023 /PRNewswire/ -- In vitro diagnostics (IVDs) remain dynamic. The IVD market is a high R&D spend industry with constant innovations and routine interest from venture capital firms in diagnostic products.  Nevertheless, the past few years have been very disruptive for IVDs. However, the resilient IVD industry has weathered the pandemic and is forging ahead with new technologies and increased opportunities that will sustain market growth through the foreseeable future.

Key Points: 
  • The IVD market is a high R&D spend industry with constant innovations and routine interest from venture capital firms in diagnostic products.
  • The global IVD test market is estimated at $106 billion in 2023 and is expected to grow 3.8% annually through 2028.
  • This conclusion is among the analysis found in The Worldwide Market for In Vitro Diagnostic Tests, 16th Edition , the brand new market research report from leading firm Kalorama Information.
  • Beyond these developments, Kalorama Information emphasizes several other key trends that will shape the present and future of IVD testing.

How encrypted Victorian newspaper personal ads shaped fiction like Sherlock and Enola Holmes

Retrieved on: 
Tuesday, May 2, 2023

You are likely familiar with its methods and central plot lines, even if you don’t know what it is!

Key Points: 
  • You are likely familiar with its methods and central plot lines, even if you don’t know what it is!
  • Anonymous personal advertisements made up the Agony Column in the mid- to late- 19th century.

Power of encryption

    • Encryption gave authors writing personal messages the ability to share private messages in a public forum.
    • Personal dramas unfolding there day after day meant the Agony Column was widely popular in 19th-century English newspapers.

Longing, tragedy and the everyday

    • Advertisements written by individuals from across the British Empire were dubbed “the agonies” by 1853 because they were full of longing, tragedy and profound misfortune shadowing the Victorian domestic everyday.
    • They occupied prime real estate in the second column on the front page of The Times.
    • Many were published anonymously or under pseudonyms, making it impossible for most readers to know who wrote them.

Fascination shaped novels

    • During the Victorian era, fascination with the Agony Column shaped both newspapers and novels.
    • Elements of sensational stories like the Constance Kent Road Hill House murder from front-page news began to appear in novels like Lady Audley’s Secret.

Comparing novels and ‘the agonies’

    • This includes access to two data sets: Our research team scraped 650,000 sentences from the Agony Column of The Times between 1860 and 1879, and over 25 million words from a corpus of 220 Victorian novels from 1800 to 1920.
    • We will use both computational analysis of those data sets, and close reading, to continue to explore ways newspapers and the Agony Column featured in and shaped Victorian novels and Victorian readers’ experiences.

Victorian detective’s perspective

    • While the agonies and coded advertisements have captured some time in the spotlight thanks to the popularity of film productions of Sherlock and Enola Holmes, understanding just how popular or influential they were on Victorian society is difficult today.
    • The game allows visitors to track coded clues in the agony columns by following fictionalized detective case notes.

Changing vocabulary

    • How far has our vocabulary shifted since that time?
    • Our research team created the Victorian Vibecheck to allow visitors to create period-appropriate text.
    • Vibecheck quantifies how rarely, if ever, words in a given text appear in our corpus of more than 450 Victorian novels.

Sherlock Biosciences Appoints Maurice Exner as Chief Scientific Officer

Retrieved on: 
Wednesday, April 12, 2023

WATERTOWN, Mass., April 12, 2023 /PRNewswire/ -- Sherlock Biosciences, a company engineering biology to bring next-generation diagnostics to the point-of-need, today announced that veteran research and development executive Maurice Exner has been appointed as the company's first Chief Scientific Officer. In his new role, Exner will serve as a member of the company's executive leadership team and be responsible for driving the company's scientific research strategy.

Key Points: 
  • WATERTOWN, Mass., April 12, 2023 /PRNewswire/ -- Sherlock Biosciences, a company engineering biology to bring next-generation diagnostics to the point-of-need, today announced that veteran research and development executive Maurice Exner has been appointed as the company's first Chief Scientific Officer.
  • In his new role, Exner will serve as a member of the company's executive leadership team and be responsible for driving the company's scientific research strategy.
  • Exner joins Sherlock with more than 20 years' experience in global research and development leadership and strategy, honed at leading biotech and diagnostic organizations including Thermo Fisher Scientific, Hologic, Abbott Point of Care and Quest Diagnostics.
  • "Sherlock has innovated a truly novel suite of chemistries and platforms, leveraging the power of CRISPR, synthetic biology and AI to transform the future of diagnostics," Exner said.

'The wilderness of mirrors': 70 years since the first James Bond book, spy stories are still blurring fact and fiction

Retrieved on: 
Wednesday, April 12, 2023

With these opening words, Ian Fleming (1908-64) introduced us to the gritty, glamorous world of James Bond.

Key Points: 
  • With these opening words, Ian Fleming (1908-64) introduced us to the gritty, glamorous world of James Bond.
  • Fleming’s first novel, Casino Royale, was published 70 years ago on April 13 1953.
  • British readers, still living with rationing and shortages after the war, eagerly devoured the first James Bond story.
  • It had expensive liquor and cars, exotic destinations, and high-stakes gambling – luxurious things beyond the reach of most people.

Ian Fleming, Agent 17F

    • He only lasted a year at military college (where he contracted gonorrhoea), then missed out on a job with the Foreign Office.
    • The director of British Naval Intelligence, Admiral John Henry Godfrey, recruited Fleming as his assistant.
    • Fleming excelled, under the codename 17F.
    • They would obtain a German bomber, dress British men in German uniforms, and deliberately crash the plane into the channel.
    • Fleming claimed he played against a German agent at the tables, an experience that supposedly inspired Bond’s gambling battles with Le Chiffre in Casino Royale.
    • Fleming also pointed to Sidney Reilly, a Russian-born British agent during the First World War.

The changing world of Bond

    • Bond novels still sold well, especially after John F. Kennedy listed one among his top ten books.
    • From Casino Royale to For Your Eyes Only (1960), Bond battled SMERSH, a real Soviet counter-espionage organisation.
    • The early Bond novels were Cold War stories.
    • In the novels, Bond drove Bentleys – the Aston Martin was introduced in the 1964 film Goldfinger.
    • Their female characters do more than just spend a night with Bond before their untimely deaths.
    • But the revised Bond novels will include a disclaimer noting the removals.

Spies After Bond

    • Le Carré introduced his readers to a more mundane, morally grey world of espionage.
    • He thought Bond was a gangster rather than a spy.
    • There’s a little more Bond in Mathews’ books than in those of le Carré or Rimington.
    • The more tedious and banal aspects of spycraft – brush passes, broken transmitters, and dead drops – accompany the glamour and romance.

The wilderness of mirrors

    • The real world of espionage is so secret that most of us only ever encounter it on pages or screens.
    • We don’t usually look to Bond films for accurate representations of espionage.
    • But the influence of Fleming’s spy and the general aura of secrecy surrounding intelligence work lend some glamour and excitement to the work of real spies.
    • This is why the CIA invests time and money into fictionalisations dealing with its work.

Crackle’s Award-winning Original Series Going From Broke’s Fourth Season Premieres Today

Retrieved on: 
Wednesday, March 1, 2023

Chicken Soup for the Soul Entertainment, Inc. (Nasdaq: CSSE), one of the largest premium content providers to value-conscious consumers, announced today the premiere of the fourth season of the award-winning Crackle original series Going From Broke.

Key Points: 
  • Chicken Soup for the Soul Entertainment, Inc. (Nasdaq: CSSE), one of the largest premium content providers to value-conscious consumers, announced today the premiere of the fourth season of the award-winning Crackle original series Going From Broke.
  • Going From Broke is now available to stream on the free Crackle app on Roku, Amazon Fire TV, Samsung TVs, and many others.
  • "I am beyond thrilled for the release of season four of Going From Broke,” said executive producer Ashton Kutcher.
  • I can't wait for audiences to see the incredible transformations that take place in this season."

Sherlock at Apex of CRISPR-based Diagnostics after USPTO Grants Earliest Priority Patent

Retrieved on: 
Tuesday, February 21, 2023

WATERTOWN, Mass., Feb. 21, 2023 /PRNewswire/ -- Sherlock Biosciences, a company engineering biology to bring next-generation lab-quality diagnostic testing to the point of need, today announced that the U.S. Patent and Trademark Office (USPTO) has granted a patent for the diagnostic use of the Cas12 enzyme, establishing Sherlock as the leader in CRISPR-based diagnostics with freedom to operate in the U.S. Sherlock has exclusive U.S. rights to the patent from Shanghai-based Tolo Biotech, plus additional intellectual property (IP) for Cas12 and Cas13 from the Broad Institute, giving the company the preeminent IP position in the space.

Key Points: 
  • The newly granted patent covers a method for detecting nucleic acids leveraging the collateral cleavage activity of Cas12.
  • Sherlock and its academic co-founders have already demonstrated the potential for flexible, high-accuracy, low-cost Cas12-based detection of diseases, including malaria, tuberculosis and COVID-19.
  • Sherlock's CRISPR-based diagnostics rely on a key pair of technologies to detect diseases, covered by the patent: amplification and collateral cleavage.
  • "With this patent, Sherlock has a clear, unimpeded pathway to commercialization for our CRISPR-based diagnostics," said Jim Collins, Ph.D., co-founder and board member of Sherlock Biosciences.

New Ansys 2023 Release Amplifies Product Design and Engineering Success for Customers Across Industries

Retrieved on: 
Thursday, January 26, 2023

PITTSBURGH, Jan. 26, 2023 /PRNewswire/ -- The software and service improvements in Ansys (NASDAQ: ANSS) 2023 R1 concentrate and amplify the incredible advantages that engineering simulation provides to multidisciplinary engineering and R&D teams. Ansys 2023 R1 enables organizations to accelerate past complexity and integration challenges to design the next generation of world-changing products by taking advantage of performance improvements, cross-discipline workflow integrations, and innovative capabilities.

Key Points: 
  • The Structures product collection delivers new features and capabilities that allow users to perform more predictively accurate, efficient, and customizable simulation analyses.
  • For example, a new capability within Ansys® Mechanical™ enables users to leverage AI/ML to determine the computational spend and time required to run a simulation.
  • Ansys Gateway powered by AWS enables developers, designers, and engineers to manage their complete Ansys simulation and computer-aided design engineering (CAD/CAE) projects from anywhere on virtually any device via a web browser.
  • Ansys and any and all ANSYS, Inc. brand, product, service and feature names, logos and slogans are registered trademarks or trademarks of ANSYS, Inc. or its subsidiaries in the United States or other countries.

HARA Brands Reimagines Freezable Glassware With Launch of New Brand KRYO

Retrieved on: 
Tuesday, January 31, 2023

LAS VEGAS, Jan. 31, 2023 (GLOBE NEWSWIRE) -- HARA Brands , the leading cannabis accessories and lifestyle brand known for revolutionizing the way customers purchase smoking accessories, announced the launch of its new brand KRYO , a high-end line of freezable glassware.

Key Points: 
  • LAS VEGAS, Jan. 31, 2023 (GLOBE NEWSWIRE) -- HARA Brands , the leading cannabis accessories and lifestyle brand known for revolutionizing the way customers purchase smoking accessories, announced the launch of its new brand KRYO , a high-end line of freezable glassware.
  • “KRYO is another example of our focus on innovation, and we couldn’t be more proud of our newest brand," said Bryan Gerber, Co-founder and CEO of HARA Brands.
  • Each hit from the KRYO Beaker Bong is cooled three times – once in the freezable bowl, once through the showerhead downstem, and lastly through the KRYO-Chamber.
  • Bubbler & Sherlock Pipes: The familiar bubble-style and sherlock pipes are upgraded with the best of KRYO, providing the coolest hits possible from a dry pipe.

The World of Biolog Gets Bigger! Biolog Adds Contract Services and New Analysis Software to Its Portfolio of Tools With the Acquisition of MIDI Labs and MIDI, Inc.

Retrieved on: 
Wednesday, January 4, 2023

Over the last two decades, both companies have served the microbial ID community, offering complimentary products and services.

Key Points: 
  • Over the last two decades, both companies have served the microbial ID community, offering complimentary products and services.
  • The acquisition will be funded through an expansion of Biolog's Series A financing, led by BroadOak Capital and Research Corporation Technologies.
  • MIDI Labs will supplement its existing offerings with Biolog's OmniLog® platform for metabolic phenotypic analysis.
  • FDA registered, USDA permitted, and ISO 17025: 2017 accredited, MIDI Labs has set the standard in providing accurate and reliable services for 25+ years.