Fracture

Elon Musk says ‘disc replacement’ worked for him. But evidence this surgery helps chronic pain is lacking

Retrieved on: 
Tuesday, April 23, 2024

In comments following the post, Musk said the surgery was a “gamechanger” and reduced his pain significantly.

Key Points: 
  • In comments following the post, Musk said the surgery was a “gamechanger” and reduced his pain significantly.
  • So what is disc replacement surgery and what does the evidence tells us about its benefits and harms?

What’s involved in a disc replacement?

  • Disc replacement may be performed for a number of reasons, including slipped discs in the neck, as appears to be the case for Musk.
  • In Australia, even if you have health insurance, a disc replacement surgery may leave you more than A$12,000 out of pocket.
  • Disc replacement surgery is not performed as much as other spinal surgeries (for example, spinal fusion) but its use is increasing.
  • In New South Wales for example, rates of privately-funded disc replacement increased six-fold from 6.2 per million people in 2010–11 to 38.4 per million in 2019–20.

What are the benefits and harms?

  • But there has been very little research comparing disc replacement surgery with non-surgical treatments.
  • Unfortunately, these crucial first research steps have largely been skipped for disc replacement surgery for both neck and back pain.
  • There are no clinical trials we know of investigating whether disc replacement is effective for neck pain compared to nothing or compared to non-surgical treatments.
  • Complications are not uncommon, and can include disclocation of the artificial disc, fracture (break) of the artificial disc, and infection.
  • Revision surgery means a re-do to the primary surgery if something needs fixing.

Are there effective alternatives?

  • Many surgeons see disc replacement as an alternative to spinal fusion, and this choice is often presented to patients.
  • Indeed, the research evidence used to support disc replacement mainly comes from studies that compare disc replacement to spinal fusion.
  • Fortunately for patients, there are new, non-surgical treatments for neck and back pain that evidence is showing are effective – and are far cheaper than surgery.
  • Christine Lin receives funding from the National Health and Medical Research Council (NHMRC), and Medical Research Future Fund.
  • Christopher Maher receives funding from the National Health and Medical Research Council (NHMRC), and Medical Research Future Fund.

Falls, fractures and self-harm: 4 charts on how kids’ injury risk changes over time and differs for boys and girls

Retrieved on: 
Thursday, April 18, 2024

At least a quarter of all emergency department presentations during childhood are injury-related.

Key Points: 
  • At least a quarter of all emergency department presentations during childhood are injury-related.
  • Injuries can be unintentional (falls, road crashes, drowning, burns) or intentional (self harm, violence, assault).
  • The type, place and cause of injury differs by age, developmental stage and sex.


children aged 1–4 years are the age group most likely to present to an emergency department with injuries
adolescents aged 16–18 years are the age group most likely to be admitted to hospital for injuries
boys are more likely to be hospitalised for injuries than girls. This continues into adulthood
girls are five times more likely to be hospitalised for intentional self-harm injuries than boys
falls are the leading cause of childhood injury, accounting for one in three child injury hospitalisations. Falls from playground equipment are the most common
fractures are the most common type of childhood injury, especially arm and wrist fractures in children aged 10–12 years.

  • For children under age one, drowning, burns, choking and suffocation had the highest injury hospital admission rates compared to adults.
  • In early childhood (ages 1-4 years), the highest causes of injury hospitalisation were drowning, burns, choking and suffocation and accidental poisoning.

What about sports?

  • Cycling causes the highest number of sporting injuries with almost 3,000 injury hospital presentations.
  • For the top 20 sports that are most likely to cause injury hospital admissions, fractures are the most common type of injury.
  • How to spot a serious injury now school and sport are back

Balancing risk and safety

  • To prevent injuries, we need to balance risk and safety.
  • Embracing risk is a fundamental part of play in all environments where children play and explore their world.
  • But with proper guidance and supervision from parents and caregivers, we can strike a balance between offering opportunities for risk-taking and ensuring children’s safety from serious harm.

What can governments do to prevent injuries?

  • This will provide clear guidance for all levels of government and others on prevention strategies and investment needed.
  • Better reporting on childhood and adolescent injury trends will better inform parents, caregivers, teachers and health professionals about the risks.
  • She is currently undertaking a project specific short term contract at the AIHW, in the Family and Domestic Violence Unit.
  • Dr Sharwood is recognised as a Professional Fellow in the Faculty of Engineering and IT, UTS, for her industry expertise in product related injuries.
  • Warwick Teague is Director of Trauma and Consultant Paediatric Surgeon at The Royal Children's Hospital Melbourne (RCH).

ALX Resources Corp. Intersects Uranium Mineralization at the Gibbons Creek Uranium Project, Athabasca Basin, Saskatchewan

Retrieved on: 
Monday, March 25, 2024

Vancouver, British Columbia--(Newsfile Corp. - March 25, 2024) - ALX Resources Corp. (TSXV: AL) (FSE: 6LLN) (OTC: ALXEF) ("ALX" or the "Company") is pleased to announce an update on the 2024 winter drilling program at its 100%-owned Gibbons Creek Uranium Project ("Gibbons Creek", or the "Project") located in the northern Athabasca Basin near the community of Stony Rapids, Saskatchewan.

Key Points: 
  • Vancouver, British Columbia--(Newsfile Corp. - March 25, 2024) - ALX Resources Corp. (TSXV: AL) (FSE: 6LLN) (OTC: ALXEF) ("ALX" or the "Company") is pleased to announce an update on the 2024 winter drilling program at its 100%-owned Gibbons Creek Uranium Project ("Gibbons Creek", or the "Project") located in the northern Athabasca Basin near the community of Stony Rapids, Saskatchewan.
  • Anomalous radioactivity and fracture-controlled uranium mineralization was intersected from 110.0 to 110.9 metres approximately 1.5 metres below the unconformity at 108.5 metres.
  • Uranium mineralization was observed as coatings on fractures in the drill core at 110.2 metres as well as other fractures between 110.0 and 110.9 metres.
  • Weather conditions remain satisfactory for the operation of equipment and personnel and the work is proceeding as scheduled.

Greenridge Exploration Provides Technical Review of its Nut Lake Uranium Project in Thelon Basin, Nunavut

Retrieved on: 
Thursday, April 4, 2024

VANCOUVER, British Columbia, April 04, 2024 (GLOBE NEWSWIRE) -- Greenridge Exploration Inc. (“Greenridge” or the “Company”) (CSE: GXP | FRA: HW3), is pleased to announce it has undertaken a detailed technical review of the Nut Lake Uranium Project (the “Nut Lake Property” or the “Project”) located in the Thelon Basin in Nunavut.

Key Points: 
  • VANCOUVER, British Columbia, April 04, 2024 (GLOBE NEWSWIRE) -- Greenridge Exploration Inc. (“Greenridge” or the “Company”) (CSE: GXP | FRA: HW3), is pleased to announce it has undertaken a detailed technical review of the Nut Lake Uranium Project (the “Nut Lake Property” or the “Project”) located in the Thelon Basin in Nunavut.
  • The Project covers approximately 4,036 hectares near the Northern Tip of the Yathkyed Basin, a sub-basin of the Thelon Basin (Please see Figure 1).
  • Russell Starr, Chief Executive Officer of the Company, commented, “We continue to unveil more exciting geological information at the Nut Lake Uranium Project.
  • The Thelon Basin and sub basins are extremely underexplored compared to the world renowned Athabasca Basin just to the south.

Stallion Uranium Drilling Intersects Anomalous Radioactivity

Retrieved on: 
Tuesday, April 2, 2024

The survey data when compiled and modeled with all available historical data showed the key characteristics for potential uranium mineralization.

Key Points: 
  • The survey data when compiled and modeled with all available historical data showed the key characteristics for potential uranium mineralization.
  • To best refine drill targets Stallion utilized the latest technology to complete an advanced ground TDEM survey over the target area.
  • Stallion Uranium requests multi-element analysis by ICP-MS and ICP-OES using total (HF:NHO3:HClO4) and partial digestion (HNO3:HCl), boron by fusion.
  • The foregoing scientific and technical disclosures for Stallion Uranium have been reviewed by Darren Slugoski, P.Geo., VP Exploration, a registered member of the Professional Engineers and Geoscientists of Saskatchewan.

White Gold Corp. Identifies Multiple Prospective IP Chargeability Anomalies on Two Large Multi-Element Porphyry Targets in Close Proximity to the Casino Copper-Gold Porphyry Deposit, Yukon, Canada

Retrieved on: 
Wednesday, March 27, 2024

All data collected thus far on these large early-stage targets continue to support a porphyry deposit model.

Key Points: 
  • All data collected thus far on these large early-stage targets continue to support a porphyry deposit model.
  • The new IP looked deeper than any previous geophysical surveys and demonstrates potential at depth beneath these large multi-element soil anomalies.
  • It’s now recommended to follow up with more IP survey lines to cover this large developing porphyry target.
  • The Bridget and Isaac targets represent large, early-stage, multi-element porphyry targets that have never been diamond drill tested.

Entera Bio Announces Key Regulatory Milestone for Oral PTH(1-34) Peptide (EB613) Phase 3 Program: FDA Ruling on Qualifying BMD as a Surrogate Endpoint for Osteoporosis Drugs is Expected Within 10 Months

Retrieved on: 
Tuesday, March 26, 2024

The proposed registrational Phase 3 study for EB613, Entera’s lead clinical candidate, which is a first-in-class PTH(1-34) daily tablet treatment for osteoporosis is designed to meet the quantitative BMD thresholds proposed by SABRE.

Key Points: 
  • The proposed registrational Phase 3 study for EB613, Entera’s lead clinical candidate, which is a first-in-class PTH(1-34) daily tablet treatment for osteoporosis is designed to meet the quantitative BMD thresholds proposed by SABRE.
  • In November 2023 we issued a press release echoing ASBMR’s announcement that SABRE had submitted its final qualification package to FDA for the replacement of fracture as a regulatory endpoint.
  • Today we are thrilled to echo ASBMR’s announcement that FDA has set a concrete timetable to issue its ruling.
  • Fractures, particularly of the hip, are considered the most serious consequence of osteoporosis, which predominantly affects postmenopausal women and older men.

Global Physical Therapy Software Market Research Report 2024: Employment Trends Catalyzing Growth, Technological Innovations - Long-term Forecast to 2028 and 2033 - ResearchAndMarkets.com

Retrieved on: 
Tuesday, April 9, 2024

The "Physical Therapy Software Global Market Report 2024" report has been added to ResearchAndMarkets.com's offering.

Key Points: 
  • The "Physical Therapy Software Global Market Report 2024" report has been added to ResearchAndMarkets.com's offering.
  • The global physical therapy software market is undergoing a significant expansion, with projections indicating a rise from $24.56 billion in 2023 to an impressive $34.87 billion by 2028, representing a steady CAGR of 7.3%.
  • A projected growth in the employment of physical therapists is forecast to have a commensurate effect on the demand for physical therapy software.
  • The consistent evolution of the physical therapy software market is indicative of a growing recognition of the critical role such technologies play in modern healthcare.

Phase 3 Comparative Clinical Study of Prolia® and Xgeva® (denosumab) Biosimilar Candidate HLX14 Met Primary Endpoints

Retrieved on: 
Monday, April 8, 2024

Shanghai Henlius Biotech, Inc. (2696.HK) and Organon (NYSE: OGN) announced that the phase 3 comparative clinical trial for the investigational Prolia® and Xgeva® (denosumab) biosimilar HLX14 met the primary endpoints.

Key Points: 
  • Shanghai Henlius Biotech, Inc. (2696.HK) and Organon (NYSE: OGN) announced that the phase 3 comparative clinical trial for the investigational Prolia® and Xgeva® (denosumab) biosimilar HLX14 met the primary endpoints.
  • In 2022, Henlius entered into a license and supply agreement with Organon for the exclusive commercialization rights to two biosimilar candidates, including HLX14.
  • The agreement covers markets such as the United States, the European Union, and Canada.
  • The primary endpoints of this study were met.

Orphan designation: Autologous CD34+ cells transduced with a lentiviral vector encoding glucosylceramidase beta Treatment of Gaucher disease, 21/08/2020 Positive

Retrieved on: 
Tuesday, April 9, 2024

Orphan designation: Autologous CD34+ cells transduced with a lentiviral vector encoding glucosylceramidase beta Treatment of Gaucher disease, 21/08/2020 Positive

Key Points: 


Orphan designation: Autologous CD34+ cells transduced with a lentiviral vector encoding glucosylceramidase beta Treatment of Gaucher disease, 21/08/2020 Positive