Oxytocin

Tonix Pharmaceuticals Receives Rare Pediatric Disease Designation from the FDA for TNX-2900 for the Treatment of Prader-Willi Syndrome

Retrieved on: 
Monday, March 25, 2024

CHATHAM, N.J., March 25, 2024 (GLOBE NEWSWIRE) -- Tonix Pharmaceuticals Holding Corp. (Nasdaq: TNXP) (Tonix or the Company), a biopharmaceutical company with marketed products and a pipeline of development candidates, today announced the U.S. Food and Drug Administration (FDA) has granted Rare Pediatric Disease Designation to TNX-2900* (intranasal potentiated oxytocin), a proprietary magnesium (Mg2+)-potentiated formulation of intranasal oxytocin, to treat Prader-Willi syndrome (PWS) in children and adolescents. TNX-2900 was previously granted Orphan Drug designation by the FDA in 2022 for the treatment of PWS and the investigational new drug (IND) application was cleared by the FDA in 2023. The Company may be eligible to receive a transferable Priority Review Voucher if TNX-2900 for PWS is approved for marketing. Recently, vouchers have sold for approximately $100 million.

Key Points: 
  • TNX-2900 was previously granted Orphan Drug designation by the FDA in 2022 for the treatment of PWS and the investigational new drug (IND) application was cleared by the FDA in 2023.
  • The Company may be eligible to receive a transferable Priority Review Voucher if TNX-2900 for PWS is approved for marketing.
  • Recently, vouchers have sold for approximately $100 million.
  • “The Rare Pediatric Disease Designation is an important regulatory milestone in the development of TNX-2900.

Tonix Pharmaceuticals Announces Poster Presentation Describing Discovery of Novel Next-Generation Oxytocin Analogues at the American Chemistry Society (ACS) Spring 2024 Meeting

Retrieved on: 
Thursday, March 21, 2024

CHATHAM, N.J., March 21, 2024 (GLOBE NEWSWIRE) -- Tonix Pharmaceuticals Holding Corp. (Nasdaq: TNXP) (Tonix or the Company), a biopharmaceutical company with marketed products and a pipeline of development candidates, today announces a poster presentation at the American Chemistry Society (ACS) Spring 2024 Meeting, held March 17-21, 2024, in New Orleans, Louisiana. A copy of the poster is available under the scientific presentations page of the Tonix website at www.tonixpharma.com.

Key Points: 
  • A copy of the poster is available under the scientific presentations page of the Tonix website at www.tonixpharma.com .
  • The poster presentation titled, Oxytocin Analogs with Enhanced Craniofacial Antinociceptive Effects in Low Magnesium Formulations, describes the discovery and characterization of novel oxytocin analogues that are candidate treatments for craniofacial pain, excessive eating (including Prader Willi Syndrome), and endocrinological conditions including bone health in autism and insulin resistance.
  • “Intranasal oxytocin has several potential therapeutic applications,” said Seth Lederman, M.D., Chief Executive Officer of Tonix Pharmaceuticals.
  • The Phase 2 ‘STROBE’ study at MGH is investigating the efficacy and safety of TNX-1900 as a novel therapeutic agent to reduce binge eating frequency in adults with binge-eating disorder.

United Breast Cancer Foundation Uplifts Those Facing Breast Cancer at Huntington Station Spring Pink Bag Event

Retrieved on: 
Monday, March 11, 2024

HUNTINGTON STATION, N.Y., March 11, 2024 /PRNewswire-PRWeb/ -- United Breast Cancer Foundation (UBCF) is excited to announce the highly anticipated return of its Spring Pink Bag Event to its Huntington Station headquarters. Taking place from Saturday, March 23rd to Wednesday, March 27th, 2024, this individualized, free "shopping" event promises to fill hearts and Pink Bags with a touch of spring cheer for breast cancer patients and survivors.

Key Points: 
  • HUNTINGTON STATION, N.Y., March 11, 2024 /PRNewswire-PRWeb/ -- United Breast Cancer Foundation (UBCF) is excited to announce the highly anticipated return of its Spring Pink Bag Event to its Huntington Station headquarters.
  • Embrace the spirit of renewal and rejuvenation by joining UBCF for the Spring Pink Bag Event.
  • UBCF is committed to supporting individuals facing this challenge, and the Spring Pink Bag Event aims to alleviate some burdens and bring joy and comfort to individuals facing breast cancer.
  • Learn more about UBCF's Spring Pink Bag Event and submit your eligibility form today at https://www.ubcf.org/march-2024-ny-pbe/

Labroots Announces Agenda for its 7th Annual Drug Discovery & Development Virtual Event on February 21, 2024

Retrieved on: 
Thursday, February 15, 2024

YORBA LINDA, Calif., Feb. 15, 2024 /PRNewswire-PRWeb/ -- Labroots, the leading scientific social networking website offering premier, interactive virtual and hybrid events and webinars, today announced its 7th annual event in the Drug Discovery & Development Virtual Event Series. Hosted on February 21st and free to attend, attendees will experience the forefront of pharmaceutical innovation joining industry and academic leaders from around the world debating the latest, insightful scientific breakthroughs in this ever-evolving field.

Key Points: 
  • Focusing from pre-clinical development to clinical development, advances in the field of drug discovery and development will be explored shaping current and future challenges in drug research
    YORBA LINDA, Calif., Feb. 15, 2024 /PRNewswire-PRWeb/ -- Labroots , the leading scientific social networking website offering premier, interactive virtual and hybrid events and webinars, today announced its 7th annual event in the Drug Discovery & Development Virtual Event Series .
  • The 2024 informative agenda covers a range of sessions spanning areas including Emerging Modalities in Drug Discovery and Preclinical Development, New Methods in Pharmacogenomics, and Biomarker Applications.
  • Use the hashtag #LRdrug to follow the conversation and connect with other members of the global Drug Discovery & Development community!
  • Follow @DrugDiscoveryLR on Twitter and @DrugDiscoveryandDevelopment on Facebook to connect with our specialist Drug Discovery & Development writers and stay up to date with the latest Trending News in Drug Discovery & Development.

How to help children and the family dog stay safe when they play together

Retrieved on: 
Tuesday, February 13, 2024

Unfortunately though, hospital admissions for dog bites are more likely to be children than adults.

Key Points: 
  • Unfortunately though, hospital admissions for dog bites are more likely to be children than adults.
  • The majority of bites on children are from a dog known to them.
  • Max is soon faced with a new child in the family, Liam, and he laments he doesn’t feel safe in his own home.

Power of play


Safe play means no shouting or roughness. Fetch, for example, can be great but be mindful if your dog is “guarding” by not relinquishing or snapping for their favourite toys. You and your children should teach your dog a leave command by trading toys for treats. Immediately throwing a second toy as soon as they bring the first back can also discourage guarding. My own son finds this game lots of fun with our dog.

  • Play is something children are usually better at than adults.
  • And for dogs, play is a natural behaviour that they don’t grow out of.

Cuddles aren’t always cute

  • Research has shown that some dogs can learn to tolerate cuddles, some even enjoy them.
  • Close physical contact between children and the family dog is a common reason dogs show aggression towards a child.

A dog needs freedom of choice

  • It isn’t difficult to allow your dog some choice in affectionate interactions from children.
  • Simply encouraging the kids to call the dog over to them where they are sitting, rather than approaching the dog themselves, can make a difference.
  • And remind children not to follow the dog if he or she moves away from them.

Don’t expect children to read dogs

  • Research has shown that young children are generally not good at recognising dog body language or facial expressions.
  • If your child can learn how to spot how dogs show certain emotions that’s great.
  • The fact that dogs have emotions too means there is always a possibility an interaction might not go well.


Anna Baatz receives funding from Dogs Trust Canine Welfare Grants.

MANGORX AWARDS SAN FRANCISCO TEAM FREE MANGORX ED PRODUCTS FOR ONE YEAR FOLLOWING BIG GAME LOSS TO KANSAS CITY

Retrieved on: 
Tuesday, February 13, 2024

Dallas, Texas, Feb. 13, 2024 (GLOBE NEWSWIRE) -- Mangoceuticals, Inc. (Nasdaq: MGRX) (“MangoRx” or the “Company”), a men’s health & wellness company, will offer a free one-year supply of its “Mango” erectile dysfunction product to the San Francisco players and coaches to raise spirits following Sunday’s Big Game loss, ensuring they can still perform in the bedroom after losing on the field.

Key Points: 
  • Players and coaches of the SF-based team can send redemption inquiries to [email protected] with subject line “The Big Game” for access to their one-year supply of Mango.
  • MangoRx’s Tadalafil and Sildenafil based Mango ED products are compounded with both Oxytocin and L-Arginine in a tasty Mango-flavored, rapid dissolve tablet (RDT).
  • “With a defeating loss, the disappointment can linger into the bedroom but we want to make sure San Francisco players and fans can still score after the game.
  • At MangoRx, we want to help take the pressure off and focus on good times ahead,” says Jacob Cohen, Co-Founder and CEO of MangoRx.

Breastfeeding benefits mothers as much as babies, but public health messaging often only tells half of the story

Retrieved on: 
Thursday, February 8, 2024

Global and U.S. health authorities agree, however, that human milk provides the optimal nutrition for infants.

Key Points: 
  • Global and U.S. health authorities agree, however, that human milk provides the optimal nutrition for infants.
  • The World Health Organization and the American Academy of Pediatrics recommend exclusive breastfeeding for the first six months of an infant’s life.
  • Human milk can be given to infants directly through breastfeeding or by pumping or expressing human milk into a cup or bottle.
  • We are women’s health scholars with combined professional expertise in maternal obstetrics nursing and public health.

Lesser-known benefits of breastfeeding for infants

  • Second, the protection from SIDS was the same for infants who were exclusively breastfed compared to infants who may have received formula in addition to any breastfeeding.
  • In addition, breastfeeding can significantly protect premature infants – those born before 37 weeks of pregnancy – from developing a condition called necrotizing enterocolitis, an inflammation of the intestines that can be fatal.
  • While this condition is rare in full-term infants, it occurs in 5% to 15% of preterm infants.

Benefits for mom, too

  • Breastfeeding also provides important benefits for the mother, such as reducing risks of diabetes and breast and ovarian cancers.
  • These cancers cannot be treated with hormonal therapy and often grow faster than the more commonly diagnosed hormone receptor-positive breast cancers.
  • A 2021 study also found that the longer a woman breastfed, the lower her risk for postpartum depression.

Closing racial gaps

  • Despite the benefits of breastfeeding to both infants and mothers, few U.S. families are able to sustain breastfeeding over time.
  • Black infant-mother pairs not only have the lowest breastfeeding rates in South Carolina, but they also have the lowest rates nationally, compared to other U.S. racial and ethnic groups.
  • Black infants are also more likely to die from SIDS and to be born prematurely.
  • The Southeast U.S. is where the widest racial gaps in breastfeeding exist.

Removing barriers to breastfeeding

  • Reducing barriers is critical to closing racial and geographic gaps in breastfeeding and allowing U.S. mothers and their infants the opportunity to benefit from the life-saving qualities of human milk.
  • Studies show that addressing work-related barriers by making investments in paid family leave, for example, could increase exclusive breastfeeding rates by 15%.
  • Workplaces that support breastfeeding breaks and provide safe and clean spaces for expressing and storing human milk are also important in promoting breastfeeding.
  • Societal investments in breastfeeding-friendly workplace policies will not only yield cost savings and extend breastfeeding rates, but they will shift the burden of breastfeeding from simply being an individual choice to being a public health priority.


Tisha Felder receives funding from the Patient Centered Research Outcomes Institute (PCORI) and National Institutes of Health (NIH). Joynelle Jackson receives funding from Patient Centered Research Outcomes Institute (PCORI).

MANGORX TO OFFER THE BIG GAME’S LOSING TEAM A FREE ONE YEAR SUPPLY OF ITS ED PRODUCT, MANGO, TO HELP RAISE… SPIRITS

Retrieved on: 
Tuesday, February 6, 2024

Dallas, Texas, Feb. 06, 2024 (GLOBE NEWSWIRE) -- Mangoceuticals, Inc. (Nasdaq: MGRX) (“MangoRx” or the “Company”), a company focused on developing, marketing, and selling a variety of men’s health and wellness products via a secure telemedicine platform, including its uniquely formulated hair growth product (“GROW”) and erectile dysfunction (“ED”) drug (“Mango”), announces that regardless of who loses the Big Game this Sunday, they are prepared to offer a free one-year supply of its Mango ED products for the entire losing team, ensuring they still get sacked after the game.

Key Points: 
  • This code will be available to fans following the results of the Big Game.
  • MangoRx’s signature ED product Mango (think "Man, Go) is a uniquely formulated drug which leverages the active ingredients found in either Cialis™ (Tadalafil) or Viagra™ (Sildenafil).
  • MangoRx’s Tadalafil and Sildenafil based Mango ED products are compounded with both Oxytocin and L-Arginine in a tasty Mango-flavored, rapid dissolve tablet (RDT).
  • “Just because your team doesn’t perform on the field, doesn’t mean the fans shouldn’t be able to score.

Brain Mechanism Teaches Mice to Avoid Bullies

Retrieved on: 
Wednesday, January 24, 2024

NEW YORK, Jan. 24, 2024 /PRNewswire/ -- Like humans, mice live in complex social groups, fight over territory and mates, and learn when it is safer to avoid certain opponents. After losing even a brief fight, the defeated animals will flee from the mice that hurt them for weeks afterward, a new study shows.

Key Points: 
  • After losing even a brief fight, the defeated animals will flee from the mice that hurt them for weeks afterward, a new study shows.
  • The team had previously found that this special region, called the anterior ventrolateral part of the ventromedial hypothalamus (aVMHvl), helps rodents defend themselves against bullies' attacks.
  • The study showed that when rival mice first meet, scent information about opponents is not strong enough to activate aVMHvl cells to prompt a retreat.
  • In addition, the findings revealed that pain prompted the immediate activation of oxytocin-releasing brain cells located right next to the aVMHvl.

Build-A-Bear Introduces SKOOSHERZ, the Newest Huggable Furry Friend Collection

Retrieved on: 
Thursday, January 18, 2024

ST. LOUIS, Jan. 18, 2024 /PRNewswire/ -- Build-A-Bear Workshop unveils a new line of collectible plush friends, SKOOSHERZ, that are uniquely styled for optimal squishing and hugging benefits. Named after a hug, or a "skoosh," these adorable spherical furry friends are made with an ultra-soft plush and extra huggable stuffing making them perfect for "skooshing." SKOOSHERZ's new look and feel are a departure from the iconic brand's signature assortment of make-your-own plush friends and will feature a variety of characters at the initial launch with new collectible versions of these charming friends expected to be released throughout the year.

Key Points: 
  • Named after a hug, or a "skoosh," these adorable spherical furry friends are made with an ultra-soft plush and extra huggable stuffing making them perfect for "skooshing."
  • "For over 25 years Build-A-Bear has been sharing furry friend hugs with guests of all ages and we are delighted to continue this tradition with this fun, new offering!"
  • The initial collection of SKOOSHERZ new huggable friends features five fan-favourite Build-A-Bear characters, including a new version of the best-selling Toy of the Year Finalist, Axolotl.
  • With its bright green fur and adorable froggy face, this SKOOSHERZ frog will become anyone's new best friend.