Tibia

Dror Paley, MD to Lead World's First Surgery with the PRECICE® Max System at Paley Orthopedic & Spine Institute

Retrieved on: 
Tuesday, February 20, 2024

WEST PALM BEACH, Fla,, Feb. 20, 2024 /PRNewswire-PRWeb/ -- Dr. Dror Paley, a globally renowned orthopedic surgeon and the Founder & CEO of the Paley Orthopedic & Spine Institute, is set to make medical history as he performs the first surgery in the world utilizing the PRECICE® Max System, developed by NuVasive Specialized Orthopedics™ (NSO), now a part of Globus Medical. This groundbreaking surgery marks a significant step forward in orthopedic innovation, emphasizing Dr. Paley's steadfast dedication to advancing the field and improving patient care. Furthermore, his selection as the inaugural surgeon further solidifies his reputation as the foremost authority in Limb Lengthening Deformity & Reconstruction Surgery worldwide.

Key Points: 
  • This groundbreaking surgery marks a significant step forward in orthopedic innovation, emphasizing Dr. Paley's steadfast dedication to advancing the field and improving patient care.
  • Furthermore, his selection as the inaugural surgeon further solidifies his reputation as the foremost authority in Limb Lengthening Deformity & Reconstruction Surgery worldwide.
  • Reflecting on the significance of this advancement, Dr. Paley stated, "I'm thrilled about the new Precice Max nail that I've contributed to developing.
  • As a global leader in orthopedic surgery, Dr. Paley's dedication to innovation and patient well-being shapes the future of orthopedic medicine.

Tyber Medical Acquires FDA Clearance for Proximal Tibia Plating System

Retrieved on: 
Monday, February 12, 2024

BETHLEHEM, Pa., Feb. 12, 2024 /PRNewswire/ -- Tyber Medical LLC, a leading orthopedic device manufacturer providing private label orthopedic implants for the trauma, extremity, and spine markets, has received a U.S. Food and Drug Administration (FDA) 510(k) approval for its Proximal Tibia Plating System. The Tyber Medical System consists of two indication categories: Complete Articular and Partial Articular Fractures. Both designs stabilize bone fragments to facilitate highly focused and efficient healing of a wide array of injuries to the tibia, fibula, and femur. "This innovative addition to the Tyber Medical portfolio aligns to meet the needs of our customers by offering multiple solutions to challenging anatomy," commented David Hannah, Chief Technology Officer at Tyber Medical. Mr. Hannah added. "This comprehensive system offers anatomic plating to support a wide range of trauma needs."

Key Points: 
  • BETHLEHEM, Pa., Feb. 12, 2024 /PRNewswire/ -- Tyber Medical LLC, a leading orthopedic device manufacturer providing private label orthopedic implants for the trauma, extremity, and spine markets, has received a U.S. Food and Drug Administration (FDA) 510(k) approval for its Proximal Tibia Plating System.
  • The Tyber Medical System consists of two indication categories: Complete Articular and Partial Articular Fractures.
  • The Tyber Medical Proximal Tibial Plating System is engineered to accommodate surgeon preferences, increase procedural efficiency, and enhance plate fit and screw placement.
  • Lisa Boyle, Director of Regulatory Affairs commented "With the clearance of the Proximal Tibial Plating System and its sub-categories, Tyber Medical remains unwavering in our commitment to providing cutting edge orthopedic solutions."

Zimmer Biomet Showcases Latest Innovations Across Comprehensive Portfolio at AAOS 2024 Annual Meeting

Retrieved on: 
Monday, February 12, 2024

WARSAW, Ind., Feb. 12, 2024 /PRNewswire/ -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), a global medical technology leader, today announced that it is showcasing the latest innovations across its product portfolio at the 2024 annual meeting of the American Academy of Orthopaedic Surgeons (AAOS) this week in San Francisco. During the meeting, the company will display its forthcoming ROSA® Robotics application for shoulder replacement,* which is pending 510(k) clearance, and provide hands-on demonstrations of key growth drivers including Persona® OsseoTi® Keel Tibia for cementless knee replacement, ROSA® Robotics (ROSA Knee and ROSA Hip), Ambulatory Surgery Center (ASC) Solutions, as well as recently launched surgical tools including HAMMR™ Automatic Hip Impaction System, and the ViVi® Surgical Helmet System.

Key Points: 
  • "Every year, the annual AAOS meeting gives us an opportunity to not only demonstrate the breadth and diversity of our portfolio, but also shine a spotlight on the bold and meaningful innovations that transform clinical care, improve the surgical experience, and give us a differentiated competitive advantage," said Mark Bezjak, President of the Americas at Zimmer Biomet.
  • ZBEdge™ Dynamic Intelligence™ : Elevates and unlocks the full potential of Zimmer Biomet's cutting-edge digital, robotic and implant solutions.
  • In addition, the company will provide updates on its ASC strategy, partnerships and comprehensive portfolio.
  • For more information about Zimmer Biomet events at AAOS 2024, visit http://www.zimmerbiomet.com/academy2024 .

Morocco dinosaur discovery gives clues on why they went extinct

Retrieved on: 
Sunday, February 11, 2024

And that suggests their demise came suddenly, with the impact of a giant asteroid.

Key Points: 
  • And that suggests their demise came suddenly, with the impact of a giant asteroid.
  • The discovery of the 180km-wide Chixculub asteroid impact crater in Mexico suggested a sudden extinction of dinosaurs and other species, driven by the impact.
  • But others have argued that a long, slow decline in dinosaur diversity contributed to their extinction.
  • It’s not just that dinosaur fossils are so rare; the fossil record is also patchy.
  • Because it’s such a huge landmass, Africa probably had far more dinosaur species than North America.

What we’ve found

  • Dinosaurs may have swum out to islands searching for food, as deer and elephants do today, and some might have drowned.
  • Other dinosaurs might have been washed out to sea by floods or storms, or drowned in rivers that carried them downstream to the ocean.
  • And so, studying marine beds, and working over many years, we’ve slowly put together a picture of Africa’s last dinosaurs, bone by bone.
  • It was smaller than Chenanisaurus, about five metres long – small by dinosaur standards, but large compared to modern predators.
  • If so, that means dinosaurs were cut down in their prime; burning out rather than fading away.

What our findings show

  • For over 100 million years, they evolved and diversified, producing a remarkable range of species: predators, herbivores, aquatic species, even flying forms, the birds.
  • Then in a single, catastrophic moment, everything was wiped out in the months of darkness caused by dust and soot from the impact.


Nicholas R. Longrich does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

Groundbreaking Allosaurus Discovery Revealed at Jurassic Mile® Dig Site in Wyoming Is Now on Display at The Children's Museum of Indianapolis

Retrieved on: 
Monday, January 8, 2024

INDIANAPOLIS, Jan. 8, 2024 /PRNewswire-PRWeb/ -- In a stunning revelation at the Jurassic Mile® dig site, the international paleontology team from The Children's Museum of Indianapolis, Naturalis Biodiversity Center and University of Manchester successfully extracted colossal sauropod fossils for the Giants of the Jurassic™ portion of the Dinosphere® exhibit but also stumbled upon a remarkable find—an articulated Allosaurus fossil.

Key Points: 
  • "Other Allosaurus have been found with skin impressions in the past, but ours contains skin from parts of the body yet to be preserved.
  • The skin is leathery and has scales like the feet of chickens or the body of crocodiles."
  • This extraordinary discovery took place during the summer of 2020 but is just now on display for the public to see at The Children's Museum.
  • Over the last few years, the Allosaurus fossil was transported to Indianapolis, with different parts arriving in stages.

HSS Study Reveals Concerning Link Between Growth Hormone Therapy and Growth Plate Fractures in Children

Retrieved on: 
Thursday, January 4, 2024

NEW YORK, Jan. 4, 2024 /PRNewswire/ -- Human growth hormone has long been used to treat certain medical conditions in children. New research from surgeon-scientists at Hospital for Special Surgery (HSS) shows that there may be a previously unknown complication.

Key Points: 
  • In children, human growth hormone therapy has been used for decades to treat growth hormone deficiency due to underlying medical conditions such as Turner syndrome, very small weight at birth, Prader-Willi syndrome and chronic renal insufficiency.
  • Given the volume of patients we treat, we were able to investigate the relationship between tibia growth plate fractures and growth hormone therapy in pediatric patients."
  • Therefore, the odds of taking growth hormone therapy were 15 times higher among patients with proximal tibia physeal avulsion fractures than the comparison group.
  • "Further research is required to tease out whether limiting specific high-impact sports will mitigate the risk of tibia growth plate fractures in active children and adolescents."

NextCure Publishes Non-Clinical Data Demonstrating Anti-Siglec-15 Treatment Prevented Bone Loss Due to Immobilization from Acute Spinal Cord Injury

Retrieved on: 
Thursday, December 21, 2023

The data demonstrated that NC605, a novel anti-Siglec-15 (S15) antibody, prevented bone loss, but more importantly preserved bone strength in animal models of severe immobilization resulting from acute spinal cord injury.

Key Points: 
  • The data demonstrated that NC605, a novel anti-Siglec-15 (S15) antibody, prevented bone loss, but more importantly preserved bone strength in animal models of severe immobilization resulting from acute spinal cord injury.
  • Following spinal cord injury, patients typically suffer rapid and extensive bone loss.
  • While anti-resorptive therapies have shown some efficacy in inhibiting bone loss, these agents also inhibit bone formation.
  • Blood and bone structure analyses revealed that the anti-S15 antibody was able to greatly inhibit bone resorption while maintaining bone formation and quality.

OrthoPediatrics Corp. Launches Pediatric Nailing Platform | Tibia

Retrieved on: 
Thursday, October 19, 2023

WARSAW, Ind., Oct. 19, 2023 (GLOBE NEWSWIRE) -- OrthoPediatrics Corp. (“OrthoPediatrics”) (NASDAQ: KIDS), a company focused exclusively on advancing the field of pediatric orthopedics, announced today it has released the new Pediatric Nailing Platform TIBIA system and successfully completed the first cases in its limited launch.

Key Points: 
  • WARSAW, Ind., Oct. 19, 2023 (GLOBE NEWSWIRE) -- OrthoPediatrics Corp. (“OrthoPediatrics”) (NASDAQ: KIDS), a company focused exclusively on advancing the field of pediatric orthopedics, announced today it has released the new Pediatric Nailing Platform TIBIA system and successfully completed the first cases in its limited launch.
  • Part of the Trauma & Deformity Correction suite of products, PNP Tibia represents another pediatric-focused solution for treating patients with fractures and deformities in the lower extremities.
  • It expands the Company’s offering to 52 unique systems designed specifically to help treat the needs of pediatric patients.
  • The PNP Tibia System features rigid cannulated nails, ranging in diameters from 7mm-12mm, and includes specialized instrumentation to facilitate multiple surgical techniques.

Cardiol Therapeutics Announces Positive Study Results Demonstrating Cardioprotective Effects of Subcutaneously Administered Cannabidiol in a Model of Heart Failure with Preserved Ejection Fraction

Retrieved on: 
Tuesday, October 10, 2023

Toronto, Ontario--(Newsfile Corp. - October 10, 2023) - Cardiol Therapeutics Inc. (NASDAQ: CRDL) (TSX: CRDL) ("Cardiol" or the "Company"), a clinical-stage life sciences company focused on the research and clinical development of anti-inflammatory and anti-fibrotic therapies for the treatment of heart disease, announces positive study results from one of its international collaborating research centers demonstrating that subcutaneously administered cannabidiol, the active pharmaceutical ingredient in Cardiol's novel CRD-38 subcutaneous ("SUBQ") formulation, slowed increases in body weight and heart weight, and prevented increases in key cardiac inflammatory and remodelling markers in a model of heart failure with preserved ejection fraction ("HFpEF").

Key Points: 
  • The study was presented by researchers from Tecnológico de Monterrey, Mexico ("TecSalud") at the Heart Failure Society of America Annual Scientific Meeting 2023 ("HFSA2023").
  • TecSalud is one of the Company's international collaborating research centers working towards the common goal of developing products to advance the treatment of heart diseases.
  • The results presented at the HFSA over the weekend demonstrated multiple cardioprotective effects of SUBQ administered cannabidiol and provide additional evidence in support of the development of CRD-38, our novel SUBQ formulation of cannabidiol intended for the treatment of heart failure.
  • The poster entitled "Cannabidiol As A Potential Treatment For Heart Failure With Preserved Ejection Fraction" was presented on October 7th within the "ePoster Viewing Session III" of HFSA2023.

Holes in baby dinosaur bones show how football-sized hatchlings grew to 3-tonne teens

Retrieved on: 
Tuesday, October 3, 2023

Despite their public image as torpid, lumbering creatures, many dinosaurs were evidently warm-blooded, highly active animals, capable of prolonged and strenuous aerobic exercise.

Key Points: 
  • Despite their public image as torpid, lumbering creatures, many dinosaurs were evidently warm-blooded, highly active animals, capable of prolonged and strenuous aerobic exercise.
  • In new research, my colleagues and I determined how much energy minibus-sized dinosaurs called Maiasaura used while growing to adulthood.

How bones heal and grow

    • Locomotion and weight-bearing activity cause stresses and strains that result in microfractures in the bones.
    • Fortunately, the leg bones of dinosaurs – like those of birds, mammals and varanid lizards such as the Komodo dragon – repair themselves in a process known as bone remodelling.
    • The main impediment to this research is the shortage of collections of bones from a single dinosaur species at different stages of growth.

‘Good mother reptile’

    • Fossils from this formation have yielded much information about the eggs, hatchlings and early lives of a dinosaur named Maiasaura (meaning “good mother reptile”).
    • This herbivorous hadrosaur apparently tended her eggs and raised her offspring for more than a year after hatching.

How to measure blood flow from bones

    • A decade ago, I wondered whether the size of the foramen could be an indirect measurement of the rate of blood flow to a bone.
    • This turned out to be true, and since then the “foramen technique” has been used on fossils to estimate blood flow rate and hence how much energy and nutrients were used in the bones of adult dinosaurs.

Rapid growth doesn’t come cheap

    • Blood flow rates calculated from foramen size were similar in one-year-old dinosaurs weighing between 189kg and 455kg and in six- to 11-year-old adults weighing between 1,680kg and 3,200kg.
    • In other words, a one-year-old had about four times as much blood flowing to each gram of its shinbone as a full-grown adult did.
    • These differences reveal how much more energy and nutrients it took to build bones in the early rapid growth stages of a Maiasaura’s life than it did to maintain the bones in adulthood.