UK Biobank

Olink® Insight Unveils Open-access Map of the Human Proteome, Aiding Biomarker Discovery and Understanding of Disease

Retrieved on: 
Tuesday, April 2, 2024
UKB, Health, Kingdom of Poland, Prostate cancer, Chronic lymphocytic leukemia, CLL, Disease, Partnership, Risk, Biomarker, Research, FCRL2, Protein, Biology, Medicine, Biobank, Data, UK Biobank, Pharmaceutical industry

In April 2023, the UK Biobank Pharma Proteomics Project (UKB-PPP) released data produced from over 50,000 samples analyzed using the Olink® Explore platform.

Key Points: 
  • In April 2023, the UK Biobank Pharma Proteomics Project (UKB-PPP) released data produced from over 50,000 samples analyzed using the Olink® Explore platform.
  • The UKB-PPP is the largest population-scale proteomics study to date, yielding an unprecedented view into the biology of diseased and healthy individuals over a 10-year period.
  • By combining protein measurements with longitudinal healthcare data for each of the individuals, Olink derived the estimated effects of ~3,000 proteins on the future risk of disease.
  • Olink Insight is a free, web-based platform that puts the results of advanced computational data analysis into the hands of non-data scientists.

GTG Global Collaborations and Innovation Update

Retrieved on: 
Tuesday, March 26, 2024
Breast cancer, Health, General practice, Professor, BRCA, Public, Public health, Disease, GTG, Risk, Patient, PRS, Research, ASX, Breast, Mammography, University, Royal Melbourne Hospital, Trial of the century, WHI, Risk assessment, Sonneborn–Berger score, Council, Biobank, Publication, Clinical trial, Cancer, CLIA, Medical research, Colorectal cancer, University of Melbourne, Government, UK Biobank, Pharmaceutical industry

MELBOURNE, Australia, March 26, 2024 (GLOBE NEWSWIRE) -- Genetic Technologies Limited (ASX: GTG; NASDAQ: GENE, “Company”, “GTG”), a global leader in genomics-based tests in health, wellness and serious disease, is pleased to highlight a summary of the Company’s commitment to innovation.

Key Points: 
  • MELBOURNE, Australia, March 26, 2024 (GLOBE NEWSWIRE) -- Genetic Technologies Limited (ASX: GTG; NASDAQ: GENE, “Company”, “GTG”), a global leader in genomics-based tests in health, wellness and serious disease, is pleased to highlight a summary of the Company’s commitment to innovation.
  • GTG is one of the co-co-principal investigators of this trial led by Professor Jon Emery.
  • GTG regards adding new expanded risk assessment tests to the company’s portfolio as a critical step in improving patient care.
  • Leveraging this approach GTG is expanding the portfolio with the following new tests:
    Leveraging the BRCA-modifier research projects GTG will develop a test that incorporates high penetrant pathogenic variant risk with PRS.

Feinstein Institutes research shows that psychiatric disorders are linked to dementia not through genetics, but alcohol use as shared cause

Retrieved on: 
Tuesday, February 6, 2024
Research, Clinical Trials, Biotechnology, Other Health, Health, Pharmaceutical, General Health, Other Science, Science, Multimedia, Memory, DSM-IV codes, Public, Language, UK Biobank, Medical research, Credit, Risk, Molecular medicine, Pharmaceutical industry

While psychiatric disorders have previously been evaluated as a predictor for dementia, a new study from researchers at The Feinstein Institutes for Medical Research provides evidence that psychiatric disorders before dementia onset are not connected to genetic dementia risks.

Key Points: 
  • While psychiatric disorders have previously been evaluated as a predictor for dementia, a new study from researchers at The Feinstein Institutes for Medical Research provides evidence that psychiatric disorders before dementia onset are not connected to genetic dementia risks.
  • “This research has helped us to recognize that alcohol use disorder greatly increases the chances of both psychiatric disorders and subsequent dementia.
  • This paves the way for future research to better inform interventions and care.”
    The study investigated the relationship between psychiatric disorders and known genetic risks of dementia.
  • The researchers conclude that shared risk factors may account for a large part of the association between psychiatric disorders and dementia, like alcohol use disorder that is a shared risk of both PDPD and dementia.

AI-Driven Study Redefines Right Heart Health Assessment With Novel Predictive Model

Retrieved on: 
Thursday, January 4, 2024
Cardiology, UK Biobank, Data-driven, MRI, Survival, American Heart, ECG, American Heart Association, Mount Sinai Health System, Research, DL, Health, Yale School of Medicine, Doctor of Philosophy, Cardiomyopathy, National Institutes of Health, AI, Artificial intelligence, Ventricular septal defect, Lung, MBBS, Bangladesh Technical Education Board, Yale New Haven Hospital, Assistant, MPH, Patient, CTSA, Diagnosis, Intelligence, Journal, Public health, Pulmonary hypertension, Yale school, Medical device

NEW YORK, Jan. 4, 2024 /PRNewswire-PRWeb/ -- Departure from traditional methods marks a significant advance in evaluating heart health, paving the way for more innovative tools and improved patient outcomes

Key Points: 
  • "This novel method could expedite the identification of heart problems, especially in the right ventricle, and potentially lead to earlier and more effective treatment.
  • It holds particular importance for patients with congenital heart disease, who often face issues in the right ventricle."
  • "Our findings mark a significant leap forward in right heart health assessment, offering a glimpse into a future where AI plays a pivotal role in early and accurate diagnosis.
  • This study was supported by the National Heart, Lung, and Blood Institute, National Institutes of Health (R01HL155915), and National Center for Advancing Translational Sciences, National Institutes of Health (CTSA grant UL1TR004419).

Epidemiology and Genetics of Clonal Hematopoiesis, a Premalignant Hematopoietic Stem Cell Condition

Retrieved on: 
Monday, November 6, 2023
Stem cell, Genetic distance, Haematopoiesis, Peripheral artery disease, Epidemiology, Smoking, Clonal hematopoiesis, Lung cancer, Genetics, Mortality, Bone marrow, Health, Carcinoma, UK Biobank, CH, Emphysema, Genome, Disease, Risk, HSC, AMGN, Gene, Chronic obstructive pulmonary disease, Gene expression, Mutation, Cardiovascular disease, Vaccine, Amgen, Nature Genetics

Clonal hematopoiesis is a condition that arises when a single clonal lineage of hematopoietic stem cells (HSC) expands and becomes the source of a substantial proportion of mature blood cells.

Key Points: 
  • Clonal hematopoiesis is a condition that arises when a single clonal lineage of hematopoietic stem cells (HSC) expands and becomes the source of a substantial proportion of mature blood cells.
  • The study reaffirmed that clonal hematopoiesis is very common in the elderly, approaching 50% in people over 80 years old.
  • Clonal hematopoiesis has many of the hallmarks of a premalignant expansion of cell clones with a potential to become cancerous.
  • Overall, the study has provided substantial insights into the genetics and epidemiology of clonal hematopoiesis.

Epidemiology and Genetics of Clonal Hematopoiesis, a Premalignant Hematopoietic Stem Cell Condition

Retrieved on: 
Monday, November 6, 2023
Stem cell, Genetic distance, Haematopoiesis, Peripheral artery disease, Epidemiology, Smoking, Clonal hematopoiesis, Lung cancer, Genetics, Mortality, Bone marrow, Health, Carcinoma, UK Biobank, CH, Emphysema, Genome, Disease, Risk, HSC, AMGN, Gene, Chronic obstructive pulmonary disease, Gene expression, Mutation, Cardiovascular disease, Vaccine, Amgen, Nature Genetics

Clonal hematopoiesis is a condition that arises when a single clonal lineage of hematopoietic stem cells (HSC) expands and becomes the source of a substantial proportion of mature blood cells.

Key Points: 
  • Clonal hematopoiesis is a condition that arises when a single clonal lineage of hematopoietic stem cells (HSC) expands and becomes the source of a substantial proportion of mature blood cells.
  • The study reaffirmed that clonal hematopoiesis is very common in the elderly, approaching 50% in people over 80 years old.
  • Clonal hematopoiesis has many of the hallmarks of a premalignant expansion of cell clones with a potential to become cancerous.
  • Overall, the study has provided substantial insights into the genetics and epidemiology of clonal hematopoiesis.

A large international study of migraine reveals new biological pathways for treatment

Retrieved on: 
Thursday, October 26, 2023
Genetic distance, Chronic pain, Aura, FinnGen, Genetics, Intermountain Health, PRRT2, DeCODE genetics, UK Biobank, Migraine, Genome, Disease, Risk, Biology, Nature Genetics, AMGN, Gene, KCNK5, Epilepsy, Myenteric plexus, Aneurysm, Aroma compound, Vaccine, Amgen

The scientists focused on detecting sequence variants associated with the the two main subtypes of migraine: migraine with aura (often referred to as classical migraine) and migraine without aura.

Key Points: 
  • The scientists focused on detecting sequence variants associated with the the two main subtypes of migraine: migraine with aura (often referred to as classical migraine) and migraine without aura.
  • The results highlight several genes that affect one of these migraine subtypes over the other, and point to new biological pathways that could be targeted for therapeutic developments.
  • Four novel migraine with aura associations were revealed and 13 variants associated primarily with migraine without aura.
  • Of particular interest were three rare variants with large effects pointing to distinct pathologies underlying different types of migraine.

A large international study of migraine reveals new biological pathways for treatment

Retrieved on: 
Thursday, October 26, 2023
Genetic distance, Chronic pain, Aura, FinnGen, Genetics, Intermountain Health, PRRT2, DeCODE genetics, UK Biobank, Migraine, Genome, Disease, Risk, Biology, Nature Genetics, AMGN, Gene, KCNK5, Epilepsy, Myenteric plexus, Aneurysm, Aroma compound, Vaccine, Amgen

The scientists focused on detecting sequence variants associated with the the two main subtypes of migraine: migraine with aura (often referred to as classical migraine) and migraine without aura.

Key Points: 
  • The scientists focused on detecting sequence variants associated with the the two main subtypes of migraine: migraine with aura (often referred to as classical migraine) and migraine without aura.
  • The results highlight several genes that affect one of these migraine subtypes over the other, and point to new biological pathways that could be targeted for therapeutic developments.
  • Four novel migraine with aura associations were revealed and 13 variants associated primarily with migraine without aura.
  • Of particular interest were three rare variants with large effects pointing to distinct pathologies underlying different types of migraine.

GeneType Predicting Risk of Pancreatic Cancer: Major Breakthrough in Early Detection and Treatment

Retrieved on: 
Wednesday, October 18, 2023
ASX, Survival, Pancreatic cancer, Ageing, Cancer, Health, Mortality, UK Biobank, Genetypes, Risk, GTG, Patient, Pharmaceutical industry, Medical imaging

GeneType’s Pancreatic Cancer risk assessment test showed a nearly 50% improvement to the traditional clinical risk score in identifying patients at a high risk of developing pancreatic cancer.

Key Points: 
  • GeneType’s Pancreatic Cancer risk assessment test showed a nearly 50% improvement to the traditional clinical risk score in identifying patients at a high risk of developing pancreatic cancer.
  • GeneType for Pancreatic Cancer will lead to a significant improvement to the number of pancreatic cancers being discovered earlier.
  • Pancreatic cancer has the poorest 5-year survival rate of any major solid tumour, but when diagnosed at an early stage, survival rates improve.
  • Implementing geneType risk assessment test for pancreatic cancer will help doctors diagnose the disease earlier, intervene earlier and reduce this appalling mortality.

Landmark studies utilizing Olink® Explore technology signal a new era for population-scale proteogenomics

Retrieved on: 
Thursday, October 5, 2023
Drug repositioning, Health, UK Biobank, Biomarker, Drug development, Proteogenomics, Data, Proteomics, Safety, UKB, Kingdom of Poland, CV, AstraZeneca, GWAS, Gene, Protein, Publication, Drug discovery, Biobank, Volunteering, Genomics, Research, Sun, Vaccine, Pharmaceutical industry, Nature

The studies each used data generated from the UK Biobank Pharma Proteomics Project (UKB-PPP), whereby 13 biopharmaceutical companies generated new proteomic data from accessing the UK Biobank.

Key Points: 
  • The studies each used data generated from the UK Biobank Pharma Proteomics Project (UKB-PPP), whereby 13 biopharmaceutical companies generated new proteomic data from accessing the UK Biobank.
  • Using the Olink Explore platform, researchers measured around 3,000 proteins in more than 54,000 UKB participant samples.
  • The findings illustrate the immense value of proteogenomics in elucidating biological mechanisms, identifying actionable new biomarkers, and accelerating drug development efforts.
  • “These landmark publications are a powerful demonstration of how next-gen proteomics can reveal crucial biological insights not seen with traditional genomics alone.