Dopamine

Human medicines European public assessment report (EPAR): Neupro, rotigotine, Date of authorisation: 15/02/2006, Revision: 33, Status: Authorised

Retrieved on: 
Tuesday, January 9, 2024

Human medicines European public assessment report (EPAR): Neupro, rotigotine, Date of authorisation: 15/02/2006, Revision: 33, Status: Authorised

Key Points: 


Human medicines European public assessment report (EPAR): Neupro, rotigotine, Date of authorisation: 15/02/2006, Revision: 33, Status: Authorised

Slim Pickings: Finding Cost-Effective Obesity Solutions

Retrieved on: 
Monday, January 8, 2024

NEW YORK, Jan. 8, 2024 /PRNewswire-PRWeb/ -- During the Middle Ages and Renaissance, a full figure was a symbol of status, indicating one's wealth, fertility and power in an environment of food scarcity. Today, it has a negative connotation. Faced with antiquity's unreliable resources, humans were hardwired to prioritize calorie-dense, energy-rich foods. To reinforce this behavior, evolution gave a boost of dopamine to big eaters; those who failed to feast during times of plenty might starve when food ran out. While abundant calorie consumption was an advantage in early societies, the ingrained drive to stock up is now a liability as access to food has become more reliable.

Key Points: 
  • Obesity presents many health risks, and expensive GLP-1 agonists have grabbed the limelight, but there are affordable and effective ways to address it.
  • While this behavior was a boon during times of food instability, constant consumption of energy dense nourishment now contributes to obesity.
  • Obesity not only increases health risks and reduces quality of life and mobility; but also produces a significant economic impact.
  • This requires alternative approaches and comprehensive efforts that combine cost-effective medications with diet and exercise to reduce excessive obesity rates.

Human medicines European public assessment report (EPAR): Neupro, rotigotine, Date of authorisation: 15/02/2006, Revision: 32, Status: Authorised

Retrieved on: 
Thursday, January 4, 2024

Human medicines European public assessment report (EPAR): Neupro, rotigotine, Date of authorisation: 15/02/2006, Revision: 32, Status: Authorised

Key Points: 


Human medicines European public assessment report (EPAR): Neupro, rotigotine, Date of authorisation: 15/02/2006, Revision: 32, Status: Authorised

The science behind building healthy habits can help you keep your New Year's resolution

Retrieved on: 
Wednesday, January 3, 2024

Despite their popularity, up to 80 per cent of resolutions fail, mostly within a few weeks.

Key Points: 
  • Despite their popularity, up to 80 per cent of resolutions fail, mostly within a few weeks.
  • I research the importance of behaviours to health, and write the Become Your Healthiest You blog.

Setting SMART resolutions

  • Using the SMART goal framework (Specific, Measurable, Attainable, Relevant and Timely) is a good foundation for setting your resolution.
  • Unfortunately, most people set vague resolutions, such as wanting to exercise more, be healthier or lose weight.
  • Also, aim for positive resolutions such as eating more vegetables, in contrast to eating no junk food.
  • In a survey of 1,066 people, those who had approach-oriented resolutions were more likely to be successful.
  • Big, long-term resolutions may be more easily approached by breaking them into smaller ones.
  • However, your resolution also needs to be challenging, as challenging ones result in better performance and are also found to be more satisfying than easier resolutions.
  • Relevant resolutions are more likely to be intrinsic in contrast with extrinsic ones, which are externally motivated (such as getting a promotion, winning a trophy or receiving praise).
  • Extrinsic resolutions tend to be fleeting while intrinsic resolutions are associated with greater well-being and satisfaction.

Succeeding at your resolution

  • In some cases, you may need to change your environment to be more supportive of your resolution.
  • If your resolution requires starting a new habit, combine it with a habit you already do.
  • If you want to start exercising, bundle it with a favourite TV show, podcast or music.
  • People who used temptation bundling with audiobooks were more likely to keep up with their exercise routine.
  • Enlisting the support of others can also help in achieving your resolution.


instrumental support consisting of someone doing something for you, such as driving you to the gym or helping in meal planning;
informational support in the form of someone giving you advice, whether it be from family, friends or professionals such as your doctor or a dietitian;
appraisal support, including evaluation and constructive feedback, which may come from the same people who provide informational support; and
emotional support from people providing love, empathy and caring.

Challenges and setbacks happen

  • Even with proper planning, challenges and setbacks can happen and are a normal part of any process of changing one’s behaviour or attempting something new.
  • Some setbacks may be temporary, such as an illness interrupting your exercise program.
  • Starting a new behaviour can sometimes be a process of trial and error, and learning from setbacks can support future success.


Scott Lear receives funding from the Canadian Institutes of Health Research and Hamilton Health Sciences, and has received funding from the Heart and Stroke Foundation, Novo Nordisk, and the Robert Wood Johnson Foundation.

Welcome to The Euphoric Life: Komowa Wellness Launches Health and Wellness Brand

Retrieved on: 
Wednesday, December 13, 2023

“Make at-home wellness accessible to everyone,” said a spokesperson for Komowa Wellness.

Key Points: 
  • “Make at-home wellness accessible to everyone,” said a spokesperson for Komowa Wellness.
  • Welcome to Komowa.”
    From the initial design to the final product, each step is meticulously planned by the expert team at Komowa Wellness to ensure that its saunas and other wellness products redefine the standards of luxury and efficiency.
  • The health and wellness brand prioritizes providing individuals access to excellent self-care tools that boost longevity and essence from the comfort of home.
  • One of the top-rated products that highlights the union between comfort, wellness, and luxury that defines Komowa Wellness’ is the brand’s Auroom Mira S 2 person outdoor sauna.

Axsome Therapeutics Hosts Solriamfetol Virtual Investor Event with Expert Thought Leaders Today

Retrieved on: 
Thursday, December 7, 2023

At the event, invited physician thought leaders will discuss current and potential future indications.

Key Points: 
  • At the event, invited physician thought leaders will discuss current and potential future indications.
  • The Axsome senior leadership team will provide an overview of clinical development plans.
  • Expert thought leaders presenting at the event include:
    Craig Chepke, MD, Medical Director of Excel Psychiatric Associates in Huntersville, N.C. and Adjunct Associate Professor of Psychiatry for Atrium Health.
  • A replay of the webcast will be available for approximately 30 days following the live event.

Axsome Therapeutics to Host Solriamfetol Virtual Investor Event on December 7

Retrieved on: 
Wednesday, November 22, 2023

At the event, invited physician thought leaders will discuss current and potential future indications.

Key Points: 
  • At the event, invited physician thought leaders will discuss current and potential future indications.
  • The Axsome senior leadership team will provide an overview of clinical development plans.
  • A live webcast of the event can be accessed on the “Webcasts & Presentations” page of the “Investors” section of the Company’s website at www.axsome.com .
  • A replay of the webcast will be available for approximately 30 days following the live event.

docbraces launches programs to help Canadians and employees smile more in 2024

Retrieved on: 
Tuesday, December 19, 2023

On January 8th, docbraces locations will launch flexsmile, a program designed to help people invest in their smile through flexible financing options that suit each patient's budget.

Key Points: 
  • On January 8th, docbraces locations will launch flexsmile, a program designed to help people invest in their smile through flexible financing options that suit each patient's budget.
  • A major stride to greater oral healthcare access, the program reflects docbraces' commitment to ensuring a confident smile is within reach for individuals and families across Canada.
  • "A healthy smile goes a long way in building self-esteem and confidence," says George Jeffrey, CEO of Canadian Orthodontic Partners, the company behind docbraces.
  • To learn more about Canadian Orthodontic Partners and its plans for a healthy 2024, please visit canadianorthodonticpartners.com

Amneal and BIAL Announce U.S. Licensing Agreement for ONGENTYS® (opicapone)

Retrieved on: 
Thursday, December 7, 2023

Amneal Pharmaceuticals, Inc. (NYSE: AMRX) (“Amneal”) and BIAL - Portela & Ca., S.A. (“BIAL”), today announced a licensing agreement where Amneal will have exclusive rights to market and distribute ONGENTYS® (opicapone) in the U.S. starting on December 18, 2023.

Key Points: 
  • Amneal Pharmaceuticals, Inc. (NYSE: AMRX) (“Amneal”) and BIAL - Portela & Ca., S.A. (“BIAL”), today announced a licensing agreement where Amneal will have exclusive rights to market and distribute ONGENTYS® (opicapone) in the U.S. starting on December 18, 2023.
  • Carbidopa/levodopa (CD/LD), which works to control the symptoms of PD, has been the gold-standard treatment for PD since the 1970s.
  • ONGENTYS® works by inhibiting the COMT enzyme – which breaks down LD – making more LD available to reach the brain, thereby reducing “Off” time.
  • The financial terms of the agreement were not disclosed, and any incremental expenses associated with this product are contemplated within Amneal’s guidance.

New study sheds light on how the brain learns to seek reward

Retrieved on: 
Wednesday, December 13, 2023

SEATTLE, Dec. 13, 2023 /PRNewswire/ -- Imagine you're teaching a dog to play fetch. You throw a ball, and your dog sprints after it, picks it up, and runs back. You then reward your panting pup with a treat.

Key Points: 
  • But now comes the real trick for your dog: figuring out which part of that sequence earned the treat.
  • Dopamine, a key chemical messenger in the brain, is known to play a crucial role in this process.
  • A study published today in Nature by scientists at the Allen Institute, Columbia University's Zuckerman Mind Brain Behavior Institute , the Champalimaud Centre for the Unknown and Seattle Children's Research Institute sheds new light on this mystery.
  • This 'rewinding' process strengthens the behavior and helps the mice progressively identify which precise actions and sequences yield the reward.