Kanazawa University

Kanazawa University research: Chromatin Accessibility: A new avenue for gene editing

Retrieved on: 
Friday, February 16, 2024
Nucleosome, ATAC, Kanazawa University, CRISPR, Gene editing, Stem cell, B cell, TFDP1, Genome, Digital selective calling, Protein, Gene, Histone, DNA, Running, Chromatin, Vaccine

KANAZAWA, Japan, Feb. 16, 2024 /PRNewswire/ -- In a study recently published in Nature Genetics, researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University explore chromatin accessibility, i.e., endogenous access pathways to the genomic DNA, and its use as a tool for gene editing.

Key Points: 
  • KANAZAWA, Japan, Feb. 16, 2024 /PRNewswire/ -- In a study recently published in Nature Genetics, researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University explore chromatin accessibility, i.e., endogenous access pathways to the genomic DNA, and its use as a tool for gene editing.
  • This phenomenon known as 'chromatin accessibility' involves a privileged set of protein molecules, many of which are still unknown.
  • Now, researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, led by Yusuke Miyanari, have used advanced genetic screening methods to unravel chromatin accessibility and its pathways.
  • In this study the genes identified by CRISPR screening were subjected to ATAC-see to confirm their involvement with chromatin accessibility.

Kanazawa University research: Chromatin Accessibility: A new avenue for gene editing

Retrieved on: 
Friday, February 16, 2024
Nucleosome, ATAC, Kanazawa University, CRISPR, Gene editing, Stem cell, B cell, TFDP1, Genome, Digital selective calling, Protein, Gene, Histone, DNA, Running, Chromatin, Vaccine

KANAZAWA, Japan, Feb. 16, 2024 /PRNewswire/ -- In a study recently published in Nature Genetics, researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University explore chromatin accessibility, i.e., endogenous access pathways to the genomic DNA, and its use as a tool for gene editing.

Key Points: 
  • KANAZAWA, Japan, Feb. 16, 2024 /PRNewswire/ -- In a study recently published in Nature Genetics, researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University explore chromatin accessibility, i.e., endogenous access pathways to the genomic DNA, and its use as a tool for gene editing.
  • This phenomenon known as 'chromatin accessibility' involves a privileged set of protein molecules, many of which are still unknown.
  • Now, researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, led by Yusuke Miyanari, have used advanced genetic screening methods to unravel chromatin accessibility and its pathways.
  • In this study the genes identified by CRISPR screening were subjected to ATAC-see to confirm their involvement with chromatin accessibility.

Kanazawa University research: Researchers observe what ubiquitination hinges on

Retrieved on: 
Wednesday, January 10, 2024
American Chemical Society, E6, Nano Letters, DNA, Structural dynamics, E pluribus unum, Tissue, Cervical cancer, Takeda, Signal transduction, Kanazawa University, Enzyme, Fig, Protein, AFM, Observation, E6AP, Cysteine, HPV, Microscope

KANAZAWA, Japan, Jan. 10, 2024 /PRNewswire/ -- Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nano Letters how the flexibility of a protein hinge plays a crucial role in the transfer of proteins in key cell processes.

Key Points: 
  • KANAZAWA, Japan, Jan. 10, 2024 /PRNewswire/ -- Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nano Letters how the flexibility of a protein hinge plays a crucial role in the transfer of proteins in key cell processes.
  • Ubiquitination – the addition of the protein ubiquitin - is a key stage in many cell processes, such as protein degradation, DNA repairs, and signal transduction.
  • Using high-speed atomic force microscopy (HS-AFM) and molecular modelling, researchers led by Hiroki Konno and Holger Flechsig at WPI-NanoLSI, Kanazawa University have identified how the mobility of a ubiquitination related enzyme hinge allows ubiquitination to take place.
  • In the 2000s Toshio Ando at Kanazawa University was able to improve the scanning speed to such an extent that moving images could be captured.

Kanazawa University research: Researchers observe what ubiquitination hinges on

Retrieved on: 
Wednesday, January 10, 2024
American Chemical Society, E6, Nano Letters, DNA, Structural dynamics, E pluribus unum, Tissue, Cervical cancer, Takeda, Signal transduction, Kanazawa University, Enzyme, Fig, Protein, AFM, Observation, E6AP, Cysteine, HPV, Microscope

KANAZAWA, Japan, Jan. 10, 2024 /PRNewswire/ -- Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nano Letters how the flexibility of a protein hinge plays a crucial role in the transfer of proteins in key cell processes.

Key Points: 
  • KANAZAWA, Japan, Jan. 10, 2024 /PRNewswire/ -- Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University report in Nano Letters how the flexibility of a protein hinge plays a crucial role in the transfer of proteins in key cell processes.
  • Ubiquitination – the addition of the protein ubiquitin - is a key stage in many cell processes, such as protein degradation, DNA repairs, and signal transduction.
  • Using high-speed atomic force microscopy (HS-AFM) and molecular modelling, researchers led by Hiroki Konno and Holger Flechsig at WPI-NanoLSI, Kanazawa University have identified how the mobility of a ubiquitination related enzyme hinge allows ubiquitination to take place.
  • In the 2000s Toshio Ando at Kanazawa University was able to improve the scanning speed to such an extent that moving images could be captured.

Kanazawa University research: Sodium channel investigation

Retrieved on: 
Wednesday, December 20, 2023
Noetics, Sodium, Map, Kanazawa University, Wakayama Medical University, The central science, AFM, Arcobacter, B cell, Cell membrane, Observation, Electric potential, Nature, Arcobacter butzleri, Cell, Nature Communications, Neuron, Microscope

KANAZAWA, Japan, Dec. 19, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nature Communications a high-speed atomic force microscopy study of the structural dynamics of sodium ion channels in cell membranes.

Key Points: 
  • KANAZAWA, Japan, Dec. 19, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nature Communications a high-speed atomic force microscopy study of the structural dynamics of sodium ion channels in cell membranes.
  • An important open question is whether the voltage sensor domains dissociate from the pore domains when the channel closes.
  • One is the sodium channel of a particular bacterium (Arcobacter butzleri), the other two are mutants thereof.
  • In recent years, researchers at Kanazawa University have further developed HS-AFM so that it can be applied for studying biochemical molecules and biomolecular processes in real-time.

Kanazawa University research: Sodium channel investigation

Retrieved on: 
Wednesday, December 20, 2023
Noetics, Sodium, Map, Kanazawa University, Wakayama Medical University, The central science, AFM, Arcobacter, B cell, Cell membrane, Observation, Electric potential, Nature, Arcobacter butzleri, Cell, Nature Communications, Neuron, Microscope

KANAZAWA, Japan, Dec. 19, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nature Communications a high-speed atomic force microscopy study of the structural dynamics of sodium ion channels in cell membranes.

Key Points: 
  • KANAZAWA, Japan, Dec. 19, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nature Communications a high-speed atomic force microscopy study of the structural dynamics of sodium ion channels in cell membranes.
  • An important open question is whether the voltage sensor domains dissociate from the pore domains when the channel closes.
  • One is the sodium channel of a particular bacterium (Arcobacter butzleri), the other two are mutants thereof.
  • In recent years, researchers at Kanazawa University have further developed HS-AFM so that it can be applied for studying biochemical molecules and biomolecular processes in real-time.

Kanazawa University research: Researchers fix the chirality of helical proteins

Retrieved on: 
Wednesday, November 15, 2023
Hydrogen, Dicarboxylic acid, Carbon, Absorption, Non-Euclidean geometry, Behavior, NMR, Kanazawa University, Acid, Paper, Nature, Sugar, Nature Communications, Robert Akins House, Field line, Capillary action, Circular dichroism, Heat, McLachlan, Environment, Helical, Fine chemical, Sulfur

KANAZAWA, Japan, Nov. 15, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nature Communications how they can control chirality inversion in α helical peptides.

Key Points: 
  • KANAZAWA, Japan, Nov. 15, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nature Communications how they can control chirality inversion in α helical peptides.
  • Now Naoki Ousaka, Mark J. MacLachlan and Shigehisa Akine at Kanazawa University in Japan have shown how they can control and fix the coil direction.
  • Helical proteins are chiral molecules, which means that the molecule's shape cannot be fitted into its mirror image.
  • In nature helical proteins often have other chiral components, such as sugars or amino acids, and these will determine which way the protein coils.

Kanazawa University research: Researchers fix the chirality of helical proteins

Retrieved on: 
Wednesday, November 15, 2023
Hydrogen, Dicarboxylic acid, Carbon, Absorption, Non-Euclidean geometry, Behavior, NMR, Kanazawa University, Acid, Paper, Nature, Sugar, Nature Communications, Robert Akins House, Field line, Capillary action, Circular dichroism, Heat, McLachlan, Environment, Helical, Fine chemical, Sulfur

KANAZAWA, Japan, Nov. 15, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nature Communications how they can control chirality inversion in α helical peptides.

Key Points: 
  • KANAZAWA, Japan, Nov. 15, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nature Communications how they can control chirality inversion in α helical peptides.
  • Now Naoki Ousaka, Mark J. MacLachlan and Shigehisa Akine at Kanazawa University in Japan have shown how they can control and fix the coil direction.
  • Helical proteins are chiral molecules, which means that the molecule's shape cannot be fitted into its mirror image.
  • In nature helical proteins often have other chiral components, such as sugars or amino acids, and these will determine which way the protein coils.

Kanazawa University research: Genetic switches in tumor development

Retrieved on: 
Thursday, November 9, 2023
Transition, Neoplasm, Triple test, Organoid, TGF, Colorectal cancer, Cancer, Differentiable function, Environment, Receptor (biochemistry), Growth, Malignancy, Kanazawa University, Transforming growth factor beta, Cytokine, EMT, Cancer research, Gene, Blood, Infection, Mutation, Vaccine, Medical imaging

KANAZAWA, Japan, Nov. 9, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Cancer Research how Kras and p53 mutations influence the tumor suppressor and promoter functions of a TGF- ß pathway.

Key Points: 
  • KANAZAWA, Japan, Nov. 9, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Cancer Research how Kras and p53 mutations influence the tumor suppressor and promoter functions of a TGF- ß pathway.
  • However, it has been established that a process known as transforming growth factor ß (TGF-ß) signaling plays a role in both tumor suppression and progression.
  • Now, Masanobu Oshima from Kanazawa University and colleagues have studied the precise genetic conditions underlying the outcome of TGF-ß signaling.
  • In certain cancer cells treated with activin, the researchers noted that the partial EMT is induced with tumor aggressiveness and development.

Kanazawa University research: Genetic switches in tumor development

Retrieved on: 
Thursday, November 9, 2023
Transition, Neoplasm, Triple test, Organoid, TGF, Colorectal cancer, Cancer, Differentiable function, Environment, Receptor (biochemistry), Growth, Malignancy, Kanazawa University, Transforming growth factor beta, Cytokine, EMT, Cancer research, Gene, Blood, Infection, Mutation, Vaccine, Medical imaging

KANAZAWA, Japan, Nov. 9, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Cancer Research how Kras and p53 mutations influence the tumor suppressor and promoter functions of a TGF- ß pathway.

Key Points: 
  • KANAZAWA, Japan, Nov. 9, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Cancer Research how Kras and p53 mutations influence the tumor suppressor and promoter functions of a TGF- ß pathway.
  • However, it has been established that a process known as transforming growth factor ß (TGF-ß) signaling plays a role in both tumor suppression and progression.
  • Now, Masanobu Oshima from Kanazawa University and colleagues have studied the precise genetic conditions underlying the outcome of TGF-ß signaling.
  • In certain cancer cells treated with activin, the researchers noted that the partial EMT is induced with tumor aggressiveness and development.