Hyperthermia

Patent Allowance Granted for ALA-002 Composition by US Patent and Trademark Office

Retrieved on: 
Wednesday, March 27, 2024
Research, Social anxiety, Composition, Brain, NCE, IPON, Environment, Patent, Incidence, Patient, University, Hyperthermia, Autism spectrum, MDXX, The central science, United States patent law, General Population (album), Test, IP, OTC, Spectrum, MDMA, Intellectual property, FDA, ASD, Food, Pharmaceutical industry

Preclinical testing has shown that the administration of ALA-002 results in significantly lowered incidence of hyperthermia, the major adverse event elicited by racemic generic MDMA.

Key Points: 
  • Preclinical testing has shown that the administration of ALA-002 results in significantly lowered incidence of hyperthermia, the major adverse event elicited by racemic generic MDMA.
  • PharmAla’s patent application included in-vivo experimental animal data, which is generally held to be stronger evidence than computational, or in-silico, modeling.
  • The Company intends to pursue its own clinical research with the novel composition, either alone or with an out-licensing partner.
  • “We are incredibly pleased that USPTO has issued an allowance for the granting of the Composition of Matter patent for ALA-002.

Stay Safe, While Staying Warm This Winter; CPSC Warns Consumers to be Cautious When Using Generators, Furnaces and Space Heaters

Retrieved on: 
Monday, February 26, 2024
Carbon, Pet, PGMA, Fire, Carbon monoxide, Bed, Hyperthermia, Poisoning, Death, Risk, Safety, CPSC, Heat, NEVER, Family, Ventilation, CO, Propane

WASHINGTON, Feb. 26, 2024 /PRNewswire/ -- As cold weather continues to impact much of the country, the U.S. Consumer Product Safety Commission (CPSC) is warning consumers about deadly hazards from home heating equipment, including space heaters, furnaces and fireplaces, based on the findings in a recent report.

Key Points: 
  • CPSC urges consumers to take safety precautions while keeping their home warm this winter.
  • A gasoline-powered generator used during weather-related power outages can produce as much CO as hundreds of cars.
  • When using electric portable heaters, ALWAYS use a wall outlet; NEVER a power strip and NEVER run the heater's cord under rugs or carpeting.
  • If a product has been recalled, stop using it immediately and contact the recalling company for the remedy--a refund, repair or replacement.

Meeting highlights from the Committee for Veterinary Medicinal Products (CVMP) 13-14 February 2024

Retrieved on: 
Saturday, February 17, 2024
Penta, Committee, Infection, Leukopenia, Lotilaner, Atopic dermatitis, Cattle, Dog, Sheep, CVMP, InterDigital, Skin, Viral, Hyperthermia, Metritis, Chicken, Horse, Viremia, Classification, Drinking water, Cat, QRD, Guideline, The Committee

The Committee adopted by consensus a positive opinion for a variation requiring assessment for Strangvac to implement the outcome of the MAH’s signal management process to add adverse reactions in the product information.

Key Points: 
  • The Committee adopted by consensus a positive opinion for a variation requiring assessment for Strangvac to implement the outcome of the MAH’s signal management process to add adverse reactions in the product information.
  • The respective target species were cattle, pigs and sheep (one product), chickens, and squirrel monkeys (one product each).
  • Concept papers, guidelines
    Quality
    The Committee adopted an annex to the Guideline on quality aspects of pharmaceutical veterinary medicines for administration via drinking water on compatibility studies between veterinary medicinal products and biocidal products (EMA/CVMP/QWP/592906/2022) following close of public consultation.
  • The comments received during the consultation procedure were taken into account for the revision of the annex.

Using ‘trip killers’ to cut short bad drug trips is potentially dangerous

Retrieved on: 
Wednesday, February 14, 2024
Social media, Anxiety, Opioid overdose, Research, Heroin, LSD, Benzodiazepine, Mirtazapine, A&E, MCPP, Perception, Ketanserin, Naloxone, Trazodone, Vomiting, Hyperthermia, Cannabinoid, Olanzapine, Drug, Plasma protein binding, Psilocybin, MDMA, The Doors of Perception, Depression, Post-traumatic stress disorder, Fear, Diazepam, Alprazolam, Agitation, AMT, Protein, PTSD, Hypoventilation, The Beatles, Brain, Mescaline, Environment, Emergency Medicine Journal, Pharmaceutical industry

As interest in psychedelics has grown, so has interest in ways to end a bad trip.

Key Points: 
  • As interest in psychedelics has grown, so has interest in ways to end a bad trip.
  • Recent research reveals that people are giving potentially dangerous advice on social media on how to stop a trip that is less than pleasurable.
  • One of the earliest descriptions of a psychedelic experience in western literature can be found in Aldous Huxley’s 1953 book The Doors of Perception.
  • Research shows that if someone is in a bad mood or depressed then they are more likely to have a bad trip, as are people who take too high a dose.

Trip killers

  • Few clinical studies have examined trip killers, but one has found that ketanserin – a drug used to treat high blood pressure – reverses the psychedelic effects of LSD.
  • A recent article in the Emergency Medical Journal analysed posts on Reddit about trip killers.
  • Trip killers were discussed most often for LSD (235 posts), magic mushrooms (143 posts) and MDMA (21 posts).

Receptor blocking

  • To kill a trip then, one simply has to give the drug user another drug that blocks (rather than activates) the 5-HT2A receptor.
  • Many prescription drugs can do this and they tend to be antipsychotic drugs.
  • Quetiapine from the list above is one popular example, while another antipsychotic, olanzapine, was mentioned in 14 posts in that study.
  • Similarly, the atypical antidepressants trazodone and mirtazapine also block the 5-HT2A receptor.


Colin Davidson has previously received funding from the National Institute on Drug Abuse (NIH, USA) and the European Community for projects related to stimulant drug abuse and novel psychoactive compounds respectively. He is currently a paid consultant with the Defence Science Technology Laboratory (MOD) working on new psychoactive compounds.

As Winter Storms Continue, CPSC Urges Families to Take Steps to Prevent Carbon Monoxide Poisoning and Fires

Retrieved on: 
Friday, January 19, 2024
Carbon, Death, Family, Bed, African Americans, Nausea, Person, Electronics, CO, Pet, Poisoning, Risk, Carbon monoxide, Hyperthermia, Ventilation, Final good, Water, Safety, PGMA, CPSC, NEVER, Weakness, Smoke, Use, Fire, Dizziness

WASHINGTON, Jan. 19, 2024 /PRNewswire/ -- The U.S. Consumer Product Safety Commission (CPSC) is urging consumers to take steps to protect themselves from carbon monoxide (CO) poisoning and fires as winter storms and bitter cold continue to impact millions of Americans.

Key Points: 
  • WASHINGTON, Jan. 19, 2024 /PRNewswire/ -- The U.S. Consumer Product Safety Commission (CPSC) is urging consumers to take steps to protect themselves from carbon monoxide (CO) poisoning and fires as winter storms and bitter cold continue to impact millions of Americans.
  • CO poisoning from portable generators can happen so quickly that exposed persons may become unconscious before recognizing the symptoms of nausea, dizziness or weakness.
  • Opening doors or windows will not provide enough ventilation to prevent the buildup of lethal levels of CO.
  • It may be convenient, but it's too close to home and puts your family at risk of CO poisoning.

As Winter Storms Impact Millions CPSC Issues Safety Tips to Help Families Prevent Carbon Monoxide Poisoning and Fires

Retrieved on: 
Wednesday, January 10, 2024
Carbon, Death, Bed, African Americans, Nausea, Person, Electronics, CO, Poisoning, Carbon monoxide, Hyperthermia, Ventilation, Final good, Water, CPSC, NEVER, Weakness, Smoke, Use, Fire, Dizziness

WASHINGTON, Jan. 10, 2024 /PRNewswire/ -- As winter storms impact much of the country this week, the U.S. Consumer Product Safety Commission (CPSC) is urging consumers to take steps to protect themselves from carbon monoxide (CO) poisoning and fires.

Key Points: 
  • WASHINGTON, Jan. 10, 2024 /PRNewswire/ -- As winter storms impact much of the country this week, the U.S. Consumer Product Safety Commission (CPSC) is urging consumers to take steps to protect themselves from carbon monoxide (CO) poisoning and fires.
  • CO poisoning from portable generators can happen so quickly that exposed persons may become unconscious before recognizing the symptoms of nausea, dizziness or weakness.
  • In the case of a power outage, follow these important life-saving tips:
    NEVER operate a portable generator inside a home, garage, basement, crawlspace or shed.
  • Opening doors or windows will not provide enough ventilation to prevent the buildup of lethal levels of CO.

OrsoBio to Present Phase 1 Data for the Liver-Targeted Mitochondrial Protonophore TLC-6740 in Development for the Treatment of Obesity at ObesityWeek® 2023

Retrieved on: 
Monday, October 16, 2023
Biotechnology, Diabetes, Health, Pharmaceutical, Clinical Trials, FRCP, Lipid, DSM-IV codes, Hepatocyte, ECG, Thermoregulation, Doctor of Philosophy, Hyperthermia, Obesity, Plasma, Insulin resistance, Yale school, Weight loss, MD, Aes, Liver, PK, Toxicity, Safety, Half-life, MAD, Vital signs, NASH, Temperature, MACE, SAD, MACP, Yale School of Medicine, Fatty liver disease, Patient, Acute toxicity, Pharmaceutical industry, Dietary supplement, Medicine

This study is exploring the safety and efficacy of TLC-6740 as an oral, first-in-class treatment for obesity and obesity-associated diseases, including diabetes and nonalcoholic steatohepatitis (NASH).

Key Points: 
  • This study is exploring the safety and efficacy of TLC-6740 as an oral, first-in-class treatment for obesity and obesity-associated diseases, including diabetes and nonalcoholic steatohepatitis (NASH).
  • Increasing cellular energy expenditure by mitochondrial uncoupling is a validated approach to weight loss, however, toxicity due to systemic uncoupling (e.g., increased body temperature) has restricted its clinical use.
  • To circumvent these potential toxicities, TLC-6740 was developed to be actively taken up by hepatocytes (liver cells), thereby avoiding high plasma exposures.
  • “These preliminary human data suggest that TLC-6740 has the potential to be a highly safe and effective mitochondrial protonophore based on the novel approach of liver targeting.”

Vehicular Child Presence Detection to Drive 3.5 Million 60GHz Automotive Radar Shipments in 2030

Retrieved on: 
Thursday, August 3, 2023
GSR, Safran Sensing Technologies Norway, Life, Field of view, TI, Volvo, ABI, Perception, Hyperthermia, UWB, Automotive industry, Research, Fatigue, Advanced driver-assistance system, Millimetre, HVAC, Death, Socionext, Radar, Child, Growth, ADAS, NCAP, NXP, Safety, CPD, Instrumentation, Infineon Technologies

Regulation and the standardized testing of fatigue detection, attention assistance, and child presence detection in safety rating agencies, such as NCAP, are driving this growth.

Key Points: 
  • Regulation and the standardized testing of fatigue detection, attention assistance, and child presence detection in safety rating agencies, such as NCAP, are driving this growth.
  • However, as safety objectives for passengers in the rear seat gain prominence, radar technologies including 60GHz and UWB-radar will complement camera sensors."
  • Millimeter-wave (mmWave) radar is the ideal technology for Child Presence Detection (CPD) delivery.
  • Volvo has pioneered the first radar-based CPD system, set for its introduction on the EX90 SUV, which will leverage three 60GHz radar sensors.

Vehicular Child Presence Detection to Drive 3.5 Million 60GHz Automotive Radar Shipments in 2030

Retrieved on: 
Thursday, August 3, 2023
GSR, Safran Sensing Technologies Norway, Life, Field of view, TI, Volvo, ABI, Perception, Hyperthermia, UWB, Automotive industry, Research, Fatigue, Advanced driver-assistance system, Millimetre, HVAC, Death, Socionext, Radar, Child, Growth, ADAS, NCAP, NXP, Safety, CPD, Instrumentation, Infineon Technologies

Regulation and the standardized testing of fatigue detection, attention assistance, and child presence detection in safety rating agencies, such as NCAP, are driving this growth.

Key Points: 
  • Regulation and the standardized testing of fatigue detection, attention assistance, and child presence detection in safety rating agencies, such as NCAP, are driving this growth.
  • However, as safety objectives for passengers in the rear seat gain prominence, radar technologies including 60GHz and UWB-radar will complement camera sensors."
  • Millimeter-wave (mmWave) radar is the ideal technology for Child Presence Detection (CPD) delivery.
  • Volvo has pioneered the first radar-based CPD system, set for its introduction on the EX90 SUV, which will leverage three 60GHz radar sensors.

Opioids and cocaine are a deadly combination – and 'polydrug' deaths are rising

Retrieved on: 
Monday, July 31, 2023
Blood pressure, Drug-related deaths in the United Kingdom, Dopamine, Consciousness, Drug overdose, Methamphetamine, Palpitations, Heroin, Stroke, Hyperthermia, European Monitoring Centre for Drugs and Drug Addiction, The Rev, Fentanyl, Brain, CDC, Amphetamine, Death, Man, Methylphenidate, Protein, Morphine, Cocaine, Hypoventilation, Risk, Euphoria, Korea Disease Control and Prevention Agency, Methadone, Center, Respiratory failure, Pharmaceutical industry, Drug, Cereal

Drug-related deaths associated with stimulants, such as cocaine, methamphetamine, amphetamine and methylphenidate, doubled between 2011 and 2021.

Key Points: 
  • Drug-related deaths associated with stimulants, such as cocaine, methamphetamine, amphetamine and methylphenidate, doubled between 2011 and 2021.
  • And deaths associated with using both stimulants and opioids, such as heroin, morphine, fentanyl and methadone, increased by about sevenfold over the same period.
  • Cocaine and methamphetamine are stimulant drugs, whereas opioids, such as heroin and methadone, are depressants.
  • Taken together, it can be seen that there may be a worldwide increase in polydrug-related deaths and in particular those involving both stimulants and opioids.