Carcinoma

• ft. of lab and office space at 300 Third Avenue in Waltham, Mass.
• View the full release here: https://www.businesswire.com/news/home/20240221278304/en/
  300 Third Avenue in Waltham, Massachusetts.
• 300 Third Avenue is a 143,533-sq.-ft. purpose-built life science building with four stories of laboratory space and 441 on-site parking spaces.
• Lincoln Property Company (“Lincoln”) is one of the largest diversified real estate services companies with 35 offices across the United States the United Kingdom and Europe.

• According to SN Bioscience, SNB-101 showed excellent efficacy compared to existing first-line treatments Abraxane® and Onivyde® in pancreatic cancer animal models.
• Based on this, it has been designated as an orphan drug by the US FDA after application in November last year.
• Orphan drug designation is a program where the US FDA facilitates the development and approval of treatments for rare/incurable or life-threatening diseases.
• By receiving an ODD for pancreatic cancer this time, SN Bioscience expects to gain momentum in indication expansion and clinical development.

• It shows definitively that the new technology is superior, and represents a seminal moment in the care of skin cancer patients using radiation.
• This study is the first to rigorously compare SRT to IGSRT, and it covers all the data that exists on IGSRT.
• Superficial radiation therapy was developed over 100 years ago ( here ) and was the standard therapy for nonmelanoma skin cancer until Mohs micrographic surgery emerged in the 1930's ( here ).
• IGSRT and the GentleCure experience will be showcased at the upcoming American Academy of Dermatology annual meeting in San Diego, at booth 3555.

• A collarium sunbed emits both UV radiation and a mix of visible wavelength colours to produce a pink or red light.
• Like an old-school sunbed, the user lies in it for ten to 20 minute sessions to quickly develop a tan.

Why were sunbeds banned?

• Commercial sunbeds have been illegal across Australia since 2016 (except for in the Northern Territory) under state-based radiation safety laws.
• Their dangers were highlighted by young Australians including Clare Oliver who developed melanoma after using sunbeds.
• Research shows people who have used sunbeds at least once have a 41% increased risk of developing melanoma, while ten or more sunbed sessions led to a 100% increased risk.

How are collarium sunbeds supposed to be different?

• Australian sellers of collarium sunbeds imply they are safe, but their machine descriptions note the use of UV radiation, particularly UVA.
• UVA is one part of the spectrum of UV radiation.
• Evidence shows all types of sunbeds increase the risk of melanoma, including those that use only UVA.

Collagen claims

• One particularly odd claim about collarium sunbeds is that they stimulate collagen.
• Collagen is the main supportive tissue in our skin.

• The reactive oxygen species generated by UVA light damage existing collagen structures and kick off a molecular chain of events that downgrades collagen-producing enzymes and increases collagen-destroying enzymes.
• Over time, a build-up of degraded collagen fragments in the skin promotes even more destruction.

What about phototherapy?

• The anti-collagen effects of UVA can also be used to treat thickened scars and keloids.
• Side-effects of UV phototherapy include tanning, itchiness, dryness, cold sore virus reactivation and, notably, premature skin ageing.

So what happens now?

• It looks like many collariums are just sunbeds rebranded with red light.
• Queensland Health is currently investigating whether these salons are breaching the state’s Radiation Safety Act, and operators could face large fines.

Katie Lee receives funding from the National Health and Medical Research Council. Anne Cust receives funding from the National Health and Medical Research Council and Medical Research Future Fund.