Hypothermia

Orphan designation: melatonin Treatment of perinatal asphyxia, 02/04/2012 Positive

Retrieved on: 
Tuesday, April 9, 2024

Overview

Key Points: 
  • Overview
    On 2 April 2012, orphan designation (EU/3/12/978) was granted by the European Commission to Dr Nicola J Robertson, United Kingdom, for melatonin for the treatment of perinatal asphyxia.
  • At the time of orphan designation, there was no treatment for perinatal asphyxia authorised in the EU.
  • Key facts
    - Active substance
    - melatonin
    - Intended use
    - Treatment of perinatal asphyxia
    - Orphan designation status
    - Positive
    - EU designation number
    - EU/3/12/978
    - Date of designation
    - Sponsor
    UCL Research Limited
    Review of designation
    The Committee for Orphan Medicinal Products reviews the orphan designation of a product if it is approved for marketing authorisation.
  • EU register of orphan medicines
    The list of medicines that have received an orphan designation in the EU is available on the European Commission's website:

RefrigiWear All-Weather Workwear Increases Safety and Productivity for Winter Workers

Retrieved on: 
Saturday, February 24, 2024

DAHLONEGA, Ga., Feb. 24, 2024 /PRNewswire-PRWeb/ -- When your "office" is the great outdoors, you're at the mercy of whatever weather blows your way. Cold, windy and wet conditions make tough jobs even tougher. Now, workers who go toe-to-toe with Old Man Winter can stay safe, warm and productive in any weather with the durable protection of insulated workwear from RefrigiWear.

Key Points: 
  • Now, workers who go toe-to-toe with Old Man Winter can stay safe, warm and productive in any weather with the durable protection of insulated workwear from RefrigiWear.
  • Focused on safety and productivity: RefrigiWear understands the unique challenges of working in the cold.
  • As the temperature goes down, the risk of cold stress and cold-related injuries goes up, endangering worker safety and threatening productivity.
  • RefrigiWear-insulated clothing increases warmth and safety for workers so they can focus on getting the job done right.

Curious Kids: why do we shiver when we feel cold?

Retrieved on: 
Monday, February 12, 2024

“Why do we shiver when we feel cold?” – Syeda, age 10, from Karachi

Key Points: 
  • “Why do we shiver when we feel cold?” – Syeda, age 10, from Karachi
    What a cool question, Syeda!
  • If our body temperature drops too low, our heart, nervous system and other organs are not able to work normally.
  • All mammals have the ability to shiver, so your pet cat or dog might shiver when they’re cold too.
  • Read more: Curious Kids: if our bodies are happy at 37℃, why do we feel so unhappy when it's too hot outside?

FDA Issues Reminder of Non-Substitution of PEDMARK® (sodium thiosulfate injection) for Pediatric Patients Receiving Cisplatin

Retrieved on: 
Thursday, February 1, 2024

PEDMARK is the first and only FDA approved therapy indicated to reduce the risk of ototoxicity (e.g., permanent hearing loss) associated with cisplatin in pediatric patients 1 month of age and older with localized, non-metastatic solid tumors.

Key Points: 
  • PEDMARK is the first and only FDA approved therapy indicated to reduce the risk of ototoxicity (e.g., permanent hearing loss) associated with cisplatin in pediatric patients 1 month of age and older with localized, non-metastatic solid tumors.
  • The FDA reminded health care providers that as stated in PEDMARK’s prescribing information , PEDMARK is not substitutable with other sodium thiosulfate products.
  • Sodium nitrite is co-packaged with sodium thiosulfate as a separate vial in some products; it is not present in PEDMARK.
  • The FDA encourages those with any questions to contact [email protected].

Endospan Releases Early TRIOMPHE IDE Study Results at Society of Thoracic Surgeons

Retrieved on: 
Tuesday, January 30, 2024

As a notice of availability to educate potential referring physicians about the TRIOMPHE study, Endospan shared the 30-day results of the first 22 patients enrolled in the TRIOMPHE IDE study in a Late-Breaking presentation at the 60th Annual Meeting of the Society of Thoracic Surgeons in San Antonio, Texas this past weekend.

Key Points: 
  • As a notice of availability to educate potential referring physicians about the TRIOMPHE study, Endospan shared the 30-day results of the first 22 patients enrolled in the TRIOMPHE IDE study in a Late-Breaking presentation at the 60th Annual Meeting of the Society of Thoracic Surgeons in San Antonio, Texas this past weekend.
  • TRIOMPHE is a multi-arm, multi-center, non-randomized, prospective, clinical study to evaluate the safety and effectiveness of NEXUS® in treating thoracic aortic lesions involving the aortic arch.
  • “NEXUS is designed for total endovascular arch repair to address the specific challenges of the aortic arch anatomy,” said Kevin Mayberry, CEO.
  • “We are pleased to see that this early data aligns with the results achieved during the EU clinical study.

Dog care below freezing − how to keep your pet warm and safe from cold weather, road salt and more this winter

Retrieved on: 
Tuesday, January 30, 2024

But in much of the country, when winter rolls around, previously hospitable conditions can quickly turn chilly and dangerous for people and pups alike.

Key Points: 
  • But in much of the country, when winter rolls around, previously hospitable conditions can quickly turn chilly and dangerous for people and pups alike.
  • Winter brings some unique challenges for dog owners, since dogs still need activity and socialization during colder seasons.
  • Studies have shown that dog owners are almost 50% less likely to walk their dogs when the weather gets cold.

Breed and age differences

  • A short-coated dog like a Chihuahua is much more susceptible to the dangers of cold weather than a thick-coated husky.
  • Age also affects cold-weather resilience.

When is my dog too cold?

  • A good rule to live by is if it is too cold for you, it is too cold for your dog.
  • Getting your dog a sweater or jacket and paw covers can provide them with protection from the elements and keep them comfortable.
  • Veterinarians also recommend closely monitoring your dog and limiting their time outside when the temperature nears the freezing point or drops below it.

Road salt dangers


Road salt that treats ice on streets and sidewalks can also harm dogs. When dogs walk on the salt, the sharp, rough edges of the salt crystals can irritate the sensitive skin on their paws.

  • Some companies make pet-safe salt, but in public it can be hard to tell what type of salt is on the ground.
  • You can also keep their paw fur trimmed to prevent snow from balling up or salt collecting in the fur.

Antifreeze risks

  • Some people pour antifreeze into their toilets when away from their home to prevent the water in the toilet from freezing.
  • Antifreeze is an exceptionally dangerous chemical to dogs and cats, as it tastes sweet but can be deadly when ingested.
  • If a pet ingests even a small amount of antifreeze, the substance causes a chemical cascade in their body that results in severe kidney damage.


Erik Christian Olstad does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

InventHelp Inventor Develops New Insulated Boots to Warm Feet (CNC-991)

Retrieved on: 
Wednesday, January 24, 2024

PITTSBURGH, Jan. 24, 2024 /PRNewswire/ -- "I wanted to create a comfortable pair of foot coverings that would keep the feet warm and toasty," said an inventor, from Fayetteville, N.C., "so I invented the DIABETIC INSULATED BOOTS.

Key Points: 
  • PITTSBURGH, Jan. 24, 2024 /PRNewswire/ -- "I wanted to create a comfortable pair of foot coverings that would keep the feet warm and toasty," said an inventor, from Fayetteville, N.C., "so I invented the DIABETIC INSULATED BOOTS.
  • My design can be worn when working, venturing out into the cold weather, or simply for warming the feet."
  • The patent-pending invention provides a pair of foot coverings that would keep the wearer's feet warm.
  • As a result, it increases comfort and it helps reduce the risk of frostbite and hypothermia experienced in the feet.

What is frostbite, what are the signs and how should we treat it?

Retrieved on: 
Wednesday, January 17, 2024

Thankfully, with the right preventative and protective measures, the human body can survive these icy temperatures.

Key Points: 
  • Thankfully, with the right preventative and protective measures, the human body can survive these icy temperatures.
  • Here’s what you need to know about identifying and treating the most common cold injury: frostbite.
  • However, despite our bodies’ inherent temperature controls, without the right protection, we might still be vulnerable to cold weather injuries.
  • For frostbite to occur, exposed body parts need to be subjected to a temperature that is below minus 0.55°C.
  • At this temperature it will take several hours for exposed skin to become frostbitten.
  • For example, temperatures in the -20s can cause frostbite on exposed skin in under 30 minutes.

Who does it affect?

  • However, with the global population beginning to live in harsher environments and an increase in winter and snow sports, this is likely to increase in the general population.
  • Reduced ability to sense the cold also increases the frostbite vulnerability of those who’ve had a stroke or have peripheral nerve damage.
  • The consumption of alcohol also reduces blood pressure, which may also reduce the amount of blood pumped to extremities.

Symptoms

  • Preserving the core body temperature is key to keeping the brain, heart, kidneys and lungs functioning and preventing hypothermia.
  • This cooling brings about tingling and numbness of the exposed areas, and skin flushes red or white as the body frantically tries to rewarm itself.
  • This initial stage is known as frostnip, and, although uncomfortable, leaves no permanent damage to tissues.

Treatment and prevention

  • For frostbite, immediate medical treatment should be sought – sadly the pain of recovery is often far worse than the injury.
  • Rewarming is the process of bringing the affected parts back to functioning body temperature.
  • However, where ice crystals have damaged tissue, blisters are common and the nerves become hypersensitive, causing excruciating pain.


Adam Taylor does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

SourceMark Medical Announces Expanded Partnership with Gentherm Medical

Retrieved on: 
Tuesday, January 9, 2024

SourceMark is proud to announce an expanded partnership with Gentherm Medical, a leading manufacturer of patient temperature management systems.

Key Points: 
  • SourceMark is proud to announce an expanded partnership with Gentherm Medical, a leading manufacturer of patient temperature management systems.
  • "I'm pleased we are strengthening our partnership with SourceMark Medical to provide world-class patient warming solutions to the U.S. healthcare market," said Gentherm Medical Senior Vice President and General Manager, Steve Fletcher.
  • "SourceMark has a proven track record of driving growth by providing superior service and solutions to hospitals and medical providers.
  • "This expanded relationship with Gentherm will allow SourceMark to provide unique and differentiated solutions to our clients that don't exist today from a single supplier."