Homeostasis

• Research has shown that changes to the composition and diversity of the microorganisms in the gut may explain these differences in immune system aging.
• However, as the composition of our gut microbiome changes with age, a low level of inflammation can become constant throughout the body.
• Let’s take a closer look at the gut microbiome and how it changes with age.

Gut microbiome imbalances in older adults

• In fact, compared to other parts of the body, the gut microbiome has the largest number of bacteria.
• In a healthy gut microbiome, there are four dominant families (or phyla) of microorganisms, including Firmicutes, Bacteroidetes, Proteobacteria and Actinobacteria.
• Firmicutes and Bacteroidetes make up around 80 to 90 per cent of the gut microbiota in the digestive tract.
• Over time, the shortage of beneficial bacteria such as Firmicutes in older adults starts to compromise the integrity of their intestinal barrier, causing it to become leaky.

How inflammaging works

• Inflammaging creates an environment that is prone to inflammation, which is caused and maintained by several factors.
• These can include microorganism imbalances in the intestines (microbial dysbiosis), psychological stress, physical inactivity, poor nutrition and chronic infections.

Maintaining a healthy balance of gut microbiota

• More specifically, probiotics help improve the function of the intestinal barrier and regulate immune responses by modifying the composition of the gut microbiome.
• It is clear that the immune system has an intricate relationship with the gut microbiome.
• A healthy and well-balanced gut microbiome will strengthen the intestinal barrier, which helps to reduce inflammation throughout the body and support the immune system.
• To achieve this, it is important to maintain a healthy and well-balanced lifestyle as we grow older.

Narveen Jandu does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

• The MHRA is the UK regulatory authority, a government agency, for medicines and medical devices.
• The MHRA is responsible for the regulation of medicines and medical devices and equipment used in healthcare and the investigation of harmful incidents.
• “We are pleased to receive authorization from the MHRA and take a step in the global expansion of our clinical development for GRI-0621.
• We are focused on driving this program forward and generating important data readouts this year,” Marc Hertz, PhD, Chief Executive Officer of GRI Bio.

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• This can lead to fluid accumulation and retinal thickening – a key feature of DME.
• They demonstrated that these senescent cells contribute to loss of barrier function, which can cause leaky blood vessels.
• This research further supports the potential for senolytic medicines to address the significant unmet need with current standard of care.”

• The award recognizes outstanding clinical research related to musculoskeletal disease or injury by investigators under 40 years old.
• Unfortunately, clinicians and researchers lack biological benchmarks to assess the repairs of these tissues, hampering the development of new therapies.
• "Therefore, the development of treatments to successfully repair or regenerate tendons is very difficult.
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