Connective tissue

Good news: midlife health is about more than a waist measurement. Here’s why

Retrieved on: 
Friday, April 19, 2024

During the appointment they measure your waist.

Key Points: 
  • During the appointment they measure your waist.
  • GPs and health professionals commonly measure waist circumference as a vital sign for health.
  • Men are at greatly increased risk of health issues if their waist circumference is greater than 102 centimetres.
  • More than two-thirds of Australian adults have waist measurements that put them at an increased risk of disease.

How much is too much?

  • A ratio of 0.6 or more places a person at the highest risk of disease.
  • This can kick off a discussion about their risk of chronic diseases and how they might address this.
  • For women, hormone levels begin changing in mid-life and this also stimulates increased fat levels particularly around the abdomen.
  • Finally, your family history and genetics can make you predisposed to gaining more abdominal fat.

Why the waist?

  • Visceral fat surrounds and infiltrates major organs such as the liver, pancreas and intestines, releasing a variety of chemicals (hormones, inflammatory signals, and fatty acids).
  • These affect inflammation, lipid metabolism, cholesterol levels and insulin resistance, contributing to the development of chronic illnesses.
  • In addition to the direct effects of hormone changes, declining levels of oestrogen change brain function, mood and motivation.
  • These psychological alterations can result in reduced physical activity and increased eating – often of comfort foods high in sugar and fat.
  • And importantly, the waist circumference (and ratio to height) is just one measure of human health.

Muscle matters

  • On current evidence, it is equally or more important for health and longevity to have higher muscle mass and better cardiorespiratory (aerobic) fitness than waist circumference within the healthy range.
  • So, if a person does have an excessive waist circumference, but they are also sedentary and have less muscle mass and aerobic fitness, then the recommendation would be to focus on an appropriate exercise program.
  • Conversely, a person with low visceral fat levels is not necessarily fit and healthy and may have quite poor aerobic fitness, muscle mass, and strength.

Getting moving is important advice

  • Exercise can counter a lot of the negative behavioural and physiological changes that are occurring during midlife including for people going through menopause.
  • And regular exercise reduces the tendency to use food and drink to help manage what can be a quite difficult time in life.
  • Measuring your waist circumference and monitoring your weight remains important.


Rob Newton receives funding from National Health and Medical Research Council, the Medical Research Future Fund, Cancer Council Western Australia, Spinal Cord Injuries Australia and the World Cancer Research Fund. Rob Newton is a board member of The Healthy Male.

Gaming and Esports Industry Veterans Launch POV Strategy and Research Agency Aiming to Help Brands Understand and Engage with Gamers

Retrieved on: 
Tuesday, April 9, 2024

DALLAS, April 9, 2024 /PRNewswire/ -- POV Strategy and Research is a new challenger, bringing their deep gaming & esports industry experience and gaming audience expertise to assist brands with insights and gaming-focused marketing strategy.

Key Points: 
  • DALLAS, April 9, 2024 /PRNewswire/ -- POV Strategy and Research is a new challenger, bringing their deep gaming & esports industry experience and gaming audience expertise to assist brands with insights and gaming-focused marketing strategy.
  • Co-founded by industry veterans Zach Eller and Justin Palacios, POV helps brands understand and engage the diverse and rapidly growing audience of gamers worldwide.
  • Recognizing this, POV Strategy and Research harnesses over a decade of combined experience in gaming and esports, having worked with leading organizations such as OpTic Gaming, GameSquare, and ZONED.
  • Additionally, POV will host a series of gaming camps aimed at introducing students to game development, gaming, and esports.

Orphan designation: (6aR, 10aR)-3-(1',1'-dimethylheptyl)-delta-8-tetrahydro-cannabinol-9-carboxylic acid Treatment of systemic sclerosis, 12/01/2017 Withdrawn

Retrieved on: 
Tuesday, April 9, 2024

Orphan designation: (6aR, 10aR)-3-(1',1'-dimethylheptyl)-delta-8-tetrahydro-cannabinol-9-carboxylic acid Treatment of systemic sclerosis, 12/01/2017 Withdrawn

Key Points: 


Orphan designation: (6aR, 10aR)-3-(1',1'-dimethylheptyl)-delta-8-tetrahydro-cannabinol-9-carboxylic acid Treatment of systemic sclerosis, 12/01/2017 Withdrawn

Inventiva announces positive results from the Phase II, LEGEND, Proof-of-Concept study combining lanifibranor with empagliflozin in patients with MASH/NASH and T2D

Retrieved on: 
Monday, March 18, 2024

Patients treated with lanifibranor in combination with empagliflozin maintained a stable weight throughout the 24 weeks study, addressing the moderate, metabolically healthy, weight gain that has been observed in some patients treated with lanifibranor.

Key Points: 
  • Patients treated with lanifibranor in combination with empagliflozin maintained a stable weight throughout the 24 weeks study, addressing the moderate, metabolically healthy, weight gain that has been observed in some patients treated with lanifibranor.
  • The treatment with lanifibranor 800mg/once daily alone or in combination with empagliflozin for 24 weeks was well tolerated, with no safety concerns reported.
  • The trial is double-blind for the placebo arm and lanifibranor (800mg daily) arm, and open-label for the combination of lanifibranor (800mg daily) and empagliflozin (10 mg daily) arm.
  • More details on these results are expected to be presented in upcoming scientific conferences and submitted for publication.

Guild Announces Career Pathways, A New Career Planning Solution To Connect Employees With Learning Programs Tied To Companies’ Most In-Demand Roles

Retrieved on: 
Wednesday, March 27, 2024

Employers are desperate to fill in-demand roles internally, with 7 in 10 hiring managers preferring to hire internal candidates, according to Guild research.

Key Points: 
  • Employers are desperate to fill in-demand roles internally, with 7 in 10 hiring managers preferring to hire internal candidates, according to Guild research.
  • Through Career Pathways, Guild’s Career Opportunity Platform™ bridges this gap by connecting career insights and business priorities with actionable steps for employees.
  • Built within Guild’s platform, Career Pathways creates the connective tissue between employees’ career goals and employers’ talent needs.
  • Guild has layered these resources within its platform and now uniquely supports employees in their end-to-end career mobility journey.

Immunis Publishes Research Showing Secretomes Improve Metabolism and Muscle While Reducing Fat in Aged Models

Retrieved on: 
Tuesday, March 19, 2024

The study, published in Aging Cell, is entitled “ Stem cell secretome-treatment improves whole-body metabolism, reduces adiposity and promotes skeletal muscle function in aged mice .” The research examines the effects of Immunis’ investigational secretome on metabolism, fat and skeletal muscle in aged mouse models.

Key Points: 
  • The study, published in Aging Cell, is entitled “ Stem cell secretome-treatment improves whole-body metabolism, reduces adiposity and promotes skeletal muscle function in aged mice .” The research examines the effects of Immunis’ investigational secretome on metabolism, fat and skeletal muscle in aged mouse models.
  • As we age, our metabolic health declines and commonly manifests as obesity, muscle atrophy, and reduced physical function.
  • Dr. Drummond’s independent research in aged mouse models shows that Immunis’ immunotherapy, IMMUNA, increases whole-body lean mass and reduces fat mass, while increasing muscle fiber area.
  • Muscle quality improved such that there was an increase in muscle ‘stem’ cells, enhanced collagen turnover, more blood vessels and decreased muscle fat.

CharmHealth Launches CharmHealthApps to Connect EHR Users With the Best Vendors to Further Advance Care

Retrieved on: 
Tuesday, March 12, 2024

CharmHealthApps, a veritable one-stop shop, is designed to facilitate the interaction between vendors, providers and patients as well as streamline integrations through CharmHealth.

Key Points: 
  • CharmHealthApps, a veritable one-stop shop, is designed to facilitate the interaction between vendors, providers and patients as well as streamline integrations through CharmHealth.
  • Vendors have significant control over their listings and product positioning to ensure that prospective customers have the latest information and reviews.
  • Additionally, CharmHealth has implemented single sign on (SSO) to enable users to sign in with their CharmHealth credentials for a safe, streamlined experience.
  • With CharmHealthApps, users gain greater access to new solutions with a seamless flow of data between selected applications and CharmHealth.

AMERICAN SKIN ASSOCIATION ANNOUNCES NEW BOARD MEMBER JOSEPH F. MEROLA, MD, MMSc, FAAD, FACR

Retrieved on: 
Thursday, April 4, 2024

NEW YORK, April 4, 2024 /PRNewswire/ -- American Skin Association (ASA) announced today that Joseph F. Merola, MD, MMSc, FAAD, FACR, will join its Board of Directors.

Key Points: 
  • NEW YORK, April 4, 2024 /PRNewswire/ -- American Skin Association (ASA) announced today that Joseph F. Merola, MD, MMSc, FAAD, FACR, will join its Board of Directors.
  • Distinguished Chair in Dermatology and is Professor at the Peter O'Donnell Jr. School of Public Health.
  • "We are proud to announce the addition of Dr. Joseph Merola to ASA's Board of Directors.
  • He was recently elected to the Board of the American Academy of Dermatology.

NaturVet recognized for innovative Scoopables® pet supplement products

Retrieved on: 
Monday, March 11, 2024

TEMECULA, Calif., March 11, 2024 /PRNewswire-PRWeb/ -- NaturVet, the 30-year pioneer and present-day innovator of the pet health and wellness industry, has been awarded the Editor's Choice Award from Pet Product News for the Scoopables line. The Scoopables line is a revolutionary supplementing delivery method that derives from the original soft chews pet parents know and love from NaturVet. The supplement line is made with bite-sized versions of the large soft chews, which are irresistibly flavored, perfect for finicky eaters and just as efficacious.

Key Points: 
  • The Scoopables line is a revolutionary supplementing delivery method that derives from the original soft chews pet parents know and love from NaturVet.
  • The supplement line is made with bite-sized versions of the large soft chews, which are irresistibly flavored, perfect for finicky eaters and just as efficacious.
  • Click to Tweet: 🐾 @NaturVet's Scoopables vet-formulated soft supplements line was recently recognized with the Editors Choice Award from @PPNIntl.
  • Hairball Aid: For cats over 12 weeks, this daily supplement with Psyllium Husk and Pumpkin helps eliminate and prevent hairballs.

Early Pulmonary Fibrosis Detection Holds the Key to Better Health Outcomes for Canadians Living with COVID-19 and Rheumatoid Arthritis

Retrieved on: 
Wednesday, February 28, 2024

Canadians who have had COVID-19, and other chronic diseases, are experiencing Pulmonary Fibrosis (PF) at significantly higher rates than others, seemingly providing a causal link that researchers are investigating.

Key Points: 
  • Research is shedding light on the growing rate of pulmonary fibrosis (PF) being found in people suffering from long-term COVID-19.
  • One study, Post COVID-19 pulmonary fibrosis; a meta-analysis study , found that almost 45% (44.9%) of study participants began suffering from PF after contracting COVID-19.
  • Canadians suffering from long COVID are encouraged to watch for the early signs of pulmonary fibrosis, a disease that is growing in this population.
  • Dr. Janet Pope's webinar includes explanations for both physicians and thousands of people living with connective tissue diseases of what pulmonary fibrosis symptoms to watch for.