Howard Hughes Medical Institute

Researchers Reveal Newfound DNA Repair Mechanism

Retrieved on: 
Wednesday, May 17, 2023
RER, NER, DNA, NYU, University School, Howard Hughes Medical Institute, RNA, Doctor of Philosophy, NYU Langone Health, Ribonucleotide, Biochemistry, Cryogenic electron microscopy, DNA repair, UV, Bacteria, Deoxyribonucleotide, DNA polymerase III holoenzyme, Pharmacology, III, National Institutes of Health, Medicine, Vaccine, Cell, Evgeny Nudler

Published online May 16 in the journal Cell, the report describes the molecular mechanism behind a DNA repair pathway that counters the mistaken inclusion of a certain type of molecular building block, ribonucleotides, into genetic codes.

Key Points: 
  • Published online May 16 in the journal Cell, the report describes the molecular mechanism behind a DNA repair pathway that counters the mistaken inclusion of a certain type of molecular building block, ribonucleotides, into genetic codes.
  • Given that ribonucleotide misincorporation can result in detrimental DNA code changes (mutations) and DNA breaks, all organisms have evolved to have a DNA repair pathway called ribonucleotide excision repair (RER) that quickly fixes such errors.
  • RNA polymerase motors down the DNA chain, reading the code of DNA "letters" as it transcribes instructions into RNA molecules, which then direct protein building.
  • Nudler and coworkers found that during this transcription process, RNA polymerase also finds DNA lesions, and then serves as a platform for the assembly of a DNA repair machine called nucleotide excision repair (NER) complex.

The Dreyfus Prize in the Chemical Sciences Winner Announced

Retrieved on: 
Friday, May 12, 2023
Research, Biotechnology, Other Education, Radiology, Collegiate, Consumer, Health, Science, Education, Other Science, Dreyfus Prize in the Chemical Sciences, Neuron, National academy, University of Chicago, Chemistry, Pritzker School, University of the Chinese Academy of Sciences, Harvard University, European Molecular Biology Organization, Breakthrough Prize in Life Sciences, Dean, Howard Hughes Medical Institute, American Academy, The Camille and Henry Dreyfus Foundation, Biomedical sciences, Multimedia, Brain, Cell, RNA, MacArthur Fellows Program, Biochemistry, Neuroscience, Chemical substance, Vilcek Foundation, National Academy of Medicine, European, University, Heineken Prizes, National Academy of Inventors, Biology, Pearl Meister Greengard Prize, L'Oréal-UNESCO For Women in Science Awards, American Philosophical Society, Genome, Breakthrough Prize, Pharmaceutical industry, Microscope, Medicine, Imaging, Biophysics

Professor of Science, Harvard University, is the recipient of the 2023 Dreyfus Prize in the Chemical Sciences.

Key Points: 
  • Professor of Science, Harvard University, is the recipient of the 2023 Dreyfus Prize in the Chemical Sciences.
  • The international biennial Prize, which includes a $250,000 award, is conferred this year in Imaging in the Chemical Sciences.
  • View the full release here: https://www.businesswire.com/news/home/20230511005909/en/
    Xiaowei Zhuang of Harvard University announced as recipient of the 2023 Dreyfus Prize in the Chemical Sciences (Photo: Business Wire)
    Zhuang receives this top honor for her pivotal contributions to Imaging in the Chemical Sciences.
  • I would like to thank the Camille and Henry Dreyfus Foundation for being a leading supporter of the chemical sciences community for over 75 years.”
    The Dreyfus Prize in the Chemical Sciences, initiated in 2009, is conferred in a specific area of chemistry each cycle.

Kanazawa University research: Experiments reveal chilli-sensitive molecular structure fluctuation changes in TRPV1

Retrieved on: 
Tuesday, May 9, 2023
Nobel Prize, National academy, 2021 Nobel Prize in Physiology or Medicine, PNAS, Transience, Ligand, TRPV1, Howard Hughes Medical Institute, Capsaicin, Temperature, Noetics, Pain, Fudan University, Literature, Protein, Thermodynamics, Nervous system, Science, AFM, Physiology, Kanazawa University, Microscope, Fine chemical

However, the mechanisms behind the function of TRPV1 have not been clear.

Key Points: 
  • However, the mechanisms behind the function of TRPV1 have not been clear.
  • Now Ayumi Sumino at Kanazawa University in Japan and Motoyuki Hattori at the Fudan University in China and their colleagues provide important insights into this mechanism.
  • Once activated, the TRPV1 channel opens, allowing ions to permeate and signalling to the nervous system that a noxious stimulant is present.
  • Antithetic effects of agonists and antagonists on the structural fluctuations of TRPV1 channel, Proceedings of the National Academy of Sciences May 8, 2023.

Kanazawa University research: Experiments reveal chilli-sensitive molecular structure fluctuation changes in TRPV1

Retrieved on: 
Tuesday, May 9, 2023
Nobel Prize, National academy, 2021 Nobel Prize in Physiology or Medicine, PNAS, Transience, Ligand, TRPV1, Howard Hughes Medical Institute, Capsaicin, Temperature, Noetics, Pain, Fudan University, Literature, Protein, Thermodynamics, Nervous system, Science, AFM, Physiology, Kanazawa University, Microscope, Fine chemical

However, the mechanisms behind the function of TRPV1 have not been clear.

Key Points: 
  • However, the mechanisms behind the function of TRPV1 have not been clear.
  • Now Ayumi Sumino at Kanazawa University in Japan and Motoyuki Hattori at the Fudan University in China and their colleagues provide important insights into this mechanism.
  • Once activated, the TRPV1 channel opens, allowing ions to permeate and signalling to the nervous system that a noxious stimulant is present.
  • Antithetic effects of agonists and antagonists on the structural fluctuations of TRPV1 channel, Proceedings of the National Academy of Sciences May 8, 2023.

The Foundation for Armenian Science and Technology (FAST) Building Innovations in Scientific Research and Education

Retrieved on: 
Thursday, April 27, 2023
Nobel Prize, Nobel Prize in Physiology or Medicine, PI, FAST, Mission Hills, Generation, Curriculum, Howard Hughes Medical Institute, Research, Adviser, Ministry, Scripps Research, LOS, Culture, Landmark, Management, Medical device, Science, Sport, Medicine, AI, Education, Physiology

LOS ANGELES, April 27, 2023 /PRNewswire/ -- The Foundation for Armenian Science and Technology (FAST), is excited to announce its 2023 Advance Armenia Gala which will be held on May 11, 2023, at The Landmark in Mission Hills, CA. This annual event is focused on amplifying FAST's Advance Armenia campaign to drive support and engagement for programs that enable FAST's mission: to foster and accelerate the advancement of science and technological innovation for Armenia and beyond. Funds raised will encourage progress in two key programs of the foundation: the ADVANCE Research Grants and Generation AI High School project.

Key Points: 
  • Funds raised will encourage progress in two key programs of the foundation: the ADVANCE Research Grants and Generation AI High School project.
  • "In Los Angeles, the Armenian community has shown tremendous support towards FAST's mission to drive innovation in the scientific ecosystem through far-reaching and cutting-edge education and research.
  • The program funds research teams under the leadership of distinguished international scientists that are working on producing globally competitive research.
  • Additionally, it takes unprecedented strides in AI education in Armenian high schools to build a sustainable pipeline of scientists.

Englewood Health Announces Two Trustee Appointments

Retrieved on: 
Wednesday, April 26, 2023
Emory University, Yale University, University, Education, Anesthesiology, Chronic lymphocytic leukemia, Bone marrow, Howard Hughes Medical Institute, Georgia Institute of Technology College of Computing, Trustee, Biomedical engineering, Doctor of Philosophy, Science, History of the University of Maryland, College Park, Adviser, Engineering, Sport, Weill Cornell Medicine, Westchester, Research, Health, American College, Leukemia, Dean (education), Management

ENGLEWOOD, N.J., April 26, 2023 /PRNewswire/ -- Two local healthcare and business leaders have been named to the Boards of Trustees of Englewood Health and its fundraising organization, the Englewood Health Foundation.

Key Points: 
  • ENGLEWOOD, N.J., April 26, 2023 /PRNewswire/ -- Two local healthcare and business leaders have been named to the Boards of Trustees of Englewood Health and its fundraising organization, the Englewood Health Foundation.
  • "As Englewood Health focuses on meeting the needs of our communities and expanding key services across northern New Jersey and beyond, the appointment of new trustees is essential to our mission," said Richard Lerner, chairman of the Board of Trustees of Englewood Health.
  • "We're excited to have such thought leaders on our governing boards," said Warren Geller, president and CEO of Englewood Health.
  • Cohen is an advocate for health and wellbeing and for encouraging children to participate in sports and other healthy activities.

Canadian science pioneers' role in the Human Genome Project shows why it’s crucial to fund research

Retrieved on: 
Tuesday, April 25, 2023
Max Planck Institute for Evolutionary Anthropology, Nobel Prize, DNA, Book, Human, University, Human genome, DNA: The Story of Life, Collins, Genealogy book, Schizophrenia, Leadership, Survival, Cancer, Howard Hughes Medical Institute, MIT, Genome, Washington University in St. Louis, 2022 Nobel Prize in Physiology or Medicine, Pandemic, Climate change, Population, Patient, Map, Cystic fibrosis, McGill University, ARD International Music Competition, United Kingdom, Canada Gairdner International Award, Health, Human Genome Project, CF, Gene, Max Planck Society, Disease, Antibiotics, Vaccine, Pharmaceutical industry, Agriculture

For the Human Genome Project, Canadians were at the forefront.

Key Points: 
  • For the Human Genome Project, Canadians were at the forefront.
  • The meeting was attended by Nobel Prize winners Walter Gilbert and James Watson, and is described as a major catalyst for the Human Genome Project in The Book of Man: The Human Genome Project and the Quest to Discover Our Genetic Heritage.

From inspiration to sequencing the genome

    • Scriver was well aware of the significance sequencing the human genome would have on clinical genetics and the impact it would have on the health of patients, including identifying genetic causes of diseases.
    • To move forward from Scriver’s inspiration, a proof of principle project was needed.
    • One of these pioneers went on to lead the even more challenging Human Genome Project.
    • Read more:
      Closing the gender gap in the life sciences is an uphill struggle

      The consequences of the discovery of DNA and the sequencing of the Human Genome have been monumental for health research globally.

Can DNA Day be of significance in Canada?

    • The dedication of our accomplished discovery researchers Tsui, Riordan and Scriver inspired and led to the Human Genome Project.
    • In addition, John Sulston was funded in the United Kingdom as part of the trio who actually sequenced the human genome.
    • Scriver, Tsui and Riordan should inspire pride for the value of discovery research in Canada that globally saves human lives.
    • Canada should remember their legacy on DNA day.

Keros Therapeutics Appoints Alpna Seth, Ph.D., to its Board of Directors

Retrieved on: 
Wednesday, April 19, 2023
Molecular biology, University of Massachusetts Chan Medical School, Advanced Management Program, Biotechnology, Drug development, University, Biochemistry, Doctor of Philosophy, Harvard University, Biogen, Howard Hughes Medical Institute, Patient, Naval Information Warfare Systems Command Program Executive Offices, Harvard Business School, Therapy, KROS, Management

“Dr.

Key Points: 
  • “Dr.
  • From July 2017 to January 2019, Dr. Seth was the Chief Operating Officer of Vir Biotechnology, Inc.
  • Prior to joining Vir, Dr. Seth was Senior Vice President and Global Head of the Biosimilars business for Biogen, Inc. since 2014.
  • She is also a graduate of the Advanced Management Program at Harvard Business School.

Turn Biotechnologies Sharpens Immunology Focus by Adding Two Cell Therapy Specialists to its Medical Advisory Board

Retrieved on: 
Thursday, April 13, 2023
GMP, Business development, ASH, ISCT, Pediatrics, Cell therapy, Cancer, Howard Hughes Medical Institute, DRS, Research, ASPHO, Biomarker, Immunotherapy, Messenger, Transplant, Organization, MDS, Malignancy, Aplastic anemia, CAR, National Cancer Institute, American Society of Pediatric Hematology/Oncology, Patient, Physician, Memorial Sloan Kettering Cancer Center, Cell, IEC, MSK, Immunodeficiency, Committee on Finance, Epigenetics, Society, International Society, Primary immunodeficiency, Pharmaceutical industry, Nursing, Vaccine, Dentistry, Ageing, MD

MOUNTAIN VIEW, Calif., April 13, 2023 /PRNewswire/ -- Turn Biotechnologies, a cell rejuvenation company developing novel mRNA medicines for untreatable, age-related conditions, announced the appointment of two preeminent physicians to the company's Medical Advisory Board.

Key Points: 
  • MOUNTAIN VIEW, Calif., April 13, 2023 /PRNewswire/ -- Turn Biotechnologies, a cell rejuvenation company developing novel mRNA medicines for untreatable, age-related conditions, announced the appointment of two preeminent physicians to the company's Medical Advisory Board.
  • Their expertise will help Turn Bio expand research and development to use the company's Epigenetic Reprogramming of Aging (ERA™) technology to increase the efficacy of immunotherapies.
  • Curran and Oved as our founding immunology medical advisors," said Anja Krammer, Turn Bio CEO.
  • He serves as Immune Effector Cell (IEC) Program Director and currently is the interim co-director of the Cell Therapy and Cell Engineering Facility (CTCEF), MSK's GMP investigational cell therapy facility.

Sonoma Biotherapeutics Appoints Leaders in Cell Therapy and Immunology to Scientific Advisory Board

Retrieved on: 
Tuesday, April 11, 2023
Health, Other Science, Clinical Trials, Research, Science, Biotechnology, Protalix BioTherapeutics, University, Microbiology, Associate professor, University School, Howard Hughes Medical Institute, United States Air Force Scientific Advisory Board, University of California, Autoimmunity, University of Washington School of Medicine, Genetics, Cell biology, Pathology, Sloan, Immune system, Benaroya Research Institute, Immunology, Inflammation, Vaccine, Management, Pharmaceutical industry, Regulatory T cell

Sonoma Biotherapeutics, Inc. , a clinical-stage biotechnology company developing engineered regulatory T cell (Treg) therapies for autoimmune and inflammatory diseases, today announced the formation of its scientific advisory board.

Key Points: 
  • Sonoma Biotherapeutics, Inc. , a clinical-stage biotechnology company developing engineered regulatory T cell (Treg) therapies for autoimmune and inflammatory diseases, today announced the formation of its scientific advisory board.
  • The advisory board will provide strategic oversight on scientific advancements, trends in autoimmunity and Treg cell biology, new technologies, and the company’s preclinical pipeline.
  • Members of the Scientific Advisory Board include:
    Alexander Rudensky, Ph.D., is Chair of the immunology program at the Sloan Kettering Institute and co-founder of Sonoma Biotherapeutics.
  • “We have assembled a world-class group of advisors to guide our research efforts,” said Fred Ramsdell, Ph.D., co-founder and Chief Scientific Officer at Sonoma Biotherapeutics, and Chair of the Scientific Advisory Board.