(Credit: Feinstein Institutes)
- (Credit: Feinstein Institutes)
The preclinical study published in the journal Molecular Medicine shows that famotidine, a histamine 2 receptor (H2R) antagonist, prevents cytokine storm in mice.
- Investigators found that increased vagus nerve signals were why famotidine injections stopped cytokine storms.
- By cutting the vagus nerve, known as a vagotomy, it prevented the ability of famotidine to stop the cytokine storms.
- Now these new results point to a role of the vagus nerve inflammatory reflex in suppressing cytokine storm during COVID-19.