CPS

Merck’s KEYTRUDA® (pembrolizumab) Reduced the Risk of Death by 38% Versus Placebo as Adjuvant Therapy for Patients With Renal Cell Carcinoma (RCC) at an Increased Risk of Recurrence Following Nephrectomy

Retrieved on: 
Saturday, January 27, 2024

At 48 months, the estimated OS rate was 91.2% for patients who received KEYTRUDA compared to 86.0% for patients who received placebo.

Key Points: 
  • At 48 months, the estimated OS rate was 91.2% for patients who received KEYTRUDA compared to 86.0% for patients who received placebo.
  • Treatment-related adverse events (TRAEs) occurred in 79.1% of patients (n=386) in the KEYTRUDA arm and 53.0% of patients (n=263) in the placebo arm.
  • Grade 3-4 TRAEs occurred in 18.6% of patients in the KEYTRUDA arm and 1.2% of patients in the placebo arm.
  • Treatment-related adverse events resulting in discontinuation of any treatment occurred in 18.2% of patients in the KEYTRUDA arm and 0.8% of patients in the placebo arm.

Claroty Appoints Shira Bar Yosef (Weizman) as Chief Customer Officer

Retrieved on: 
Wednesday, January 17, 2024

NEW YORK, Jan. 17, 2024 /PRNewswire/ -- Claroty, the cyber-physical systems protection company, today announced the appointment of Shira Bar Yosef (Weizman) as its first-ever Chief Customer Officer. In her role as CCO, she will leverage her 20-plus years of experience in customer support, professional services, research and development, and sales operations at industry-leading cybersecurity companies to fortify the customer journey and expand opportunities to enhance all areas of the customer experience. She will focus on ensuring a strong link between Claroty's customer relationships and strategy and the product and business roadmap.

Key Points: 
  • NEW YORK, Jan. 17, 2024 /PRNewswire/ -- Claroty , the cyber-physical systems protection company, today announced the appointment of Shira Bar Yosef (Weizman) as its first-ever Chief Customer Officer.
  • She will focus on ensuring a strong link between Claroty's customer relationships and strategy and the product and business roadmap.
  • Bar Yosef most recently served as general manager of Israel and SVP of technical customer experience at Cybereason.
  • "I'm thrilled to be joining Claroty, where the customer-centric mindset is deeply ingrained in the culture," said Bar Yosef.

Appia Announces Significant Geochemical Critical REE Assay Results at Alces Lake Project, Saskatchewan, Canada

Retrieved on: 
Monday, January 15, 2024

Commencing on June 11th, 2023, Appia initiated a comprehensive 3456.72-metre helicopter-supported diamond drilling program, concluding all field operations on August 24th.

Key Points: 
  • Commencing on June 11th, 2023, Appia initiated a comprehensive 3456.72-metre helicopter-supported diamond drilling program, concluding all field operations on August 24th.
  • The Company has received all assay results stemming from its 2023 summer geochemical exploration initiative.
  • Appia is engaged in the compilation, review, and interpretation of these results across all investigated areas.
  • "The identification of the Magnet Ridge Zone following the 2022 drill campaign was a major success to further delineate potential mineralization at Alces Lake.

Sensydia Completes Fifth Study for Heart-Sound AI

Retrieved on: 
Tuesday, January 16, 2024

Non-invasive cardiac assessment company Sensydia announced today that it has completed its 50-subject development study at the University of Minnesota (UMN).

Key Points: 
  • Non-invasive cardiac assessment company Sensydia announced today that it has completed its 50-subject development study at the University of Minnesota (UMN).
  • In January 2022, Sensydia announced that CPS was granted Breakthrough Device Designation by the United States Food and Drug Administration (FDA).
  • Sensydia plans to use data from this 50-subject study to develop the CPS pulmonary pressure algorithms.
  • The achievement of this 50-subject milestone comes at a time when Sensydia is actively executing Phase I of its new NIH award.

Why the Post Office was able to bring private prosecutions in the Horizon IT scandal

Retrieved on: 
Tuesday, January 16, 2024

That the Post Office was able to bring so many prosecutions – and to conduct them so appallingly – is because the company was not supervised.

Key Points: 
  • That the Post Office was able to bring so many prosecutions – and to conduct them so appallingly – is because the company was not supervised.
  • Just as any other public company or private citizen might, the Post Office brought private prosecutions.
  • As co-directors of the Criminal Law Reform Now Network, we have been working on a review of private prosecutions since 2019.

How private prosecutions are brought

  • To bring a private prosecution, a person or company asks a magistrate to issue a summons against the accused person.
  • When the accused person answers the summons, an ordinary criminal case ensues – not a civil case.
  • This is one duty which the Post Office manifestly declined to perform, as has been highlighted by statutory inquiry into the Post Office Horizon scandal.

Safeguards for private prosecutions

  • There has long been the possibility for the director of public prosecutions (DPP) – who, since 1986, is the head of the CPS – to take over a private prosecution or discontinue it.
  • Since 2009, the policy has been to discontinue private prosecutions which do not meet the same core standards (that there be a realistic prospect of prosecution or that a prosecution is in the public interest) with which the CPS must comply.
  • However, it would normally be up to the accused person themselves to ask that the DDP or CPS should take it over, and the decision would still be made on the basis of the files in the possession of the private prosecutor.

Private prosecutions should be reformed, not abolished

  • It is important not to look at private prosecutions entirely through the prism of the Post Office scandal.
  • Where wealthy and determined victims have the means to investigate and prosecute effectively, they may, in fact, be doing a public service.
  • Some succesful private prosecutions have led to confiscation orders being made against convicted defendants that have resulted in millions of pounds being handed over to the Treasury.
  • In recent years, many legal firms specialising in private prosecutions have formed their own Private Prosecutors’ Association.


The authors do not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and have disclosed no relevant affiliations beyond their academic appointment.

FDA Approves Merck’s KEYTRUDA® (pembrolizumab) Plus Chemoradiotherapy as Treatment for Patients With FIGO 2014 Stage III-IVA Cervical Cancer

Retrieved on: 
Friday, January 12, 2024

Important immune-mediated adverse reactions listed here may not include all possible severe and fatal immune-mediated adverse reactions.

Key Points: 
  • Important immune-mediated adverse reactions listed here may not include all possible severe and fatal immune-mediated adverse reactions.
  • “Building on the established role of KEYTRUDA in advanced cervical cancer, KEYTRUDA plus chemoradiotherapy is now the first anti-PD-1-based regimen approved in the U.S. for the treatment of patients with FIGO 2014 Stage III-IVA cervical cancer regardless of PD-L1 expression,” said Dr. Gursel Aktan, vice president, global clinical development, Merck Research Laboratories.
  • The trial enrolled 1,060 patients with cervical cancer who had not previously received any definitive surgery, radiation, or systemic therapy for cervical cancer.
  • In the exploratory subgroup analysis of 596 patients with FIGO 2014 Stage III-IVA disease, 61 patients (21%) in the KEYTRUDA plus CRT arm (n=293) experienced a PFS event versus 94 patients (31%) in the placebo plus CRT arm (n=303).

TXOne Networks Recognized by TSMC for Technical Cooperation in OT Cybersecurity for Semiconductor Foundry Global Leader

Retrieved on: 
Tuesday, January 9, 2024

TXOne Networks , a leader in Cyber-Physical Systems (CPS) security, announced that the company has been recognized by TSMC (TWSE: 2330, NYSE: TSM), the world's first dedicated semiconductor foundry, for outstanding performance in technical cooperation in operational technology (OT) cybersecurity.

Key Points: 
  • TXOne Networks , a leader in Cyber-Physical Systems (CPS) security, announced that the company has been recognized by TSMC (TWSE: 2330, NYSE: TSM), the world's first dedicated semiconductor foundry, for outstanding performance in technical cooperation in operational technology (OT) cybersecurity.
  • In 2021, TSMC established the "SEMI Taiwan Cybersecurity Committee," introducing the first international standard, SEMI E187, and launching the "SEMI Cybersecurity Risk Rating Service."
  • The company also released the "Cybersecurity Reference Architecture for Semiconductor Manufacturing Environment," enhancing cybersecurity measures in the semiconductor industry worldwide.
  • Together, we strive within the Semiconductor Cybersecurity Committee to define best practices for OT cybersecurity in the semiconductor industry.

POLITICAL EXPERT CASEY BURGAT LAUNCHES NEW, PROVOCATIVE PODCAST WITH AN EXCEPTIONALLY RENOWNED GUEST LIST

Retrieved on: 
Thursday, January 11, 2024

WASHINGTON, Jan. 11, 2024 /PRNewswire/ -- As the nation's focus narrows in on the upcoming presidential election and in tandem with the Iowa Caucus on January 15, regarded political analyst and George Washington University professor, Casey Burgat launches political podcast, Mastering the Room. The riveting 20 to 30-minute-per-episode program welcomes the most powerful and influential names in politics throughout DC and beyond into its studio to discuss oftentimes polarizing topics and relegate in perspectives that are rarely recorded and shared.

Key Points: 
  • WASHINGTON, Jan. 11, 2024 /PRNewswire/ -- As the nation's focus narrows in on the upcoming presidential election and in tandem with the Iowa Caucus on January 15, regarded political analyst and George Washington University professor, Casey Burgat launches political podcast, Mastering the Room .
  • "George Washington University remains committed to honesty and integrity as a standard of excellence and common practice.
  • "The conversations he's encouraging and actually having are a true testament to the university's tenants and values."
  • Needless to say, there are hundreds of political podcasts, but only "Mastering the Room" explores current topical and trending issues with honesty and integrity of GW.

First Student and Cincinnati Public Schools to Deploy District's First Electric School Buses

Retrieved on: 
Thursday, January 11, 2024

The funding for the electric school buses comes from the EPA's Clean School Bus Program, which is designed to accelerate the deployment of electric school buses across the U.S.

Key Points: 
  • The funding for the electric school buses comes from the EPA's Clean School Bus Program, which is designed to accelerate the deployment of electric school buses across the U.S.
  • In its second round of funding, the EPA awarded First Student the funding to deploy more than 370 new electric school buses in school districts across the country, bringing zero-emission student transportation to more communities, including Cincinnati.
  • "The deployment of electric school buses will mean lower emissions on our streets, around our schools, and in the air our children breathe.
  • In November 2022, the EPA granted First Student with funds to provide 12 school districts with a total of 170 electric school buses.

VTG Awarded $80M Hypersonics Engineering Prime Contract from Navy Strategic Systems Programs

Retrieved on: 
Tuesday, January 9, 2024

The U.S. Navy Strategic Systems Programs awarded the contract to VTG on a sole source basis.

Key Points: 
  • The U.S. Navy Strategic Systems Programs awarded the contract to VTG on a sole source basis.
  • The Defense Department has identified hypersonics as a critical technology vital to strengthening the United States military's technological superiority and maintaining national security.
  • CPS will provide the Navy with a hypersonic conventional weapon capable of precise, long-range strike against time critical and high value targets.
  • The Navy is the lead designer for the common hypersonic missile that will be fielded by both the Navy and the Army.