Nucleosome

Kanazawa University research: Chromatin Accessibility: A new avenue for gene editing

Retrieved on: 
Friday, February 16, 2024
Nucleosome, ATAC, Kanazawa University, CRISPR, Gene editing, Stem cell, B cell, TFDP1, Genome, Digital selective calling, Protein, Gene, Histone, DNA, Running, Chromatin, Vaccine

KANAZAWA, Japan, Feb. 16, 2024 /PRNewswire/ -- In a study recently published in Nature Genetics, researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University explore chromatin accessibility, i.e., endogenous access pathways to the genomic DNA, and its use as a tool for gene editing.

Key Points: 
  • KANAZAWA, Japan, Feb. 16, 2024 /PRNewswire/ -- In a study recently published in Nature Genetics, researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University explore chromatin accessibility, i.e., endogenous access pathways to the genomic DNA, and its use as a tool for gene editing.
  • This phenomenon known as 'chromatin accessibility' involves a privileged set of protein molecules, many of which are still unknown.
  • Now, researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, led by Yusuke Miyanari, have used advanced genetic screening methods to unravel chromatin accessibility and its pathways.
  • In this study the genes identified by CRISPR screening were subjected to ATAC-see to confirm their involvement with chromatin accessibility.

Kanazawa University research: Chromatin Accessibility: A new avenue for gene editing

Retrieved on: 
Friday, February 16, 2024
Nucleosome, ATAC, Kanazawa University, CRISPR, Gene editing, Stem cell, B cell, TFDP1, Genome, Digital selective calling, Protein, Gene, Histone, DNA, Running, Chromatin, Vaccine

KANAZAWA, Japan, Feb. 16, 2024 /PRNewswire/ -- In a study recently published in Nature Genetics, researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University explore chromatin accessibility, i.e., endogenous access pathways to the genomic DNA, and its use as a tool for gene editing.

Key Points: 
  • KANAZAWA, Japan, Feb. 16, 2024 /PRNewswire/ -- In a study recently published in Nature Genetics, researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University explore chromatin accessibility, i.e., endogenous access pathways to the genomic DNA, and its use as a tool for gene editing.
  • This phenomenon known as 'chromatin accessibility' involves a privileged set of protein molecules, many of which are still unknown.
  • Now, researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, led by Yusuke Miyanari, have used advanced genetic screening methods to unravel chromatin accessibility and its pathways.
  • In this study the genes identified by CRISPR screening were subjected to ATAC-see to confirm their involvement with chromatin accessibility.

Antech launches breakthrough in-hospital innovation, Nu.Q® Canine Cancer Test

Retrieved on: 
Friday, January 12, 2024
Element, Hemangiosarcoma, VMX, Volition, EDTA, Dog, Science, Pet, Cancer, Lymphoma, Plasma, Disease, DVM, Transport, Nucleosome, Telehealth, Veterinarian

ORLANDO, Fla., Jan. 12, 2024 /PRNewswire/ -- Antech, the veterinary diagnostics company focused on helping veterinary professionals predict, diagnose and monitor wellness and disease, today announced it will launch the breakthrough in-hospital Nu.Q® Canine Cancer Test at this year's annual VMX meeting.

Key Points: 
  • ORLANDO, Fla., Jan. 12, 2024 /PRNewswire/ -- Antech, the veterinary diagnostics company focused on helping veterinary professionals predict, diagnose and monitor wellness and disease, today announced it will launch the breakthrough in-hospital Nu.Q® Canine Cancer Test at this year's annual VMX meeting.
  • Nu.Q ® is a breakthrough technology that measures circulating nucleosomes, supporting earlier cancer detection in some of the most prevalent types of canine cancers.
  • To learn more about the in-hospital Nu.Q ®, visit booth 1522 at VMX 2024 or speak to your local Antech representative.
  • The Nu.Q® Canine Cancer Test is supplied to Antech's Heska affiliate under license by Belgian Volition SRL.

Antech launches first comprehensive veterinary diagnostics offering in the UK, including a new state-of-the-art reference laboratory

Retrieved on: 
Tuesday, November 7, 2023
Science, Cancer, Veterinarian, AIS, Mars, Incorporated, Head, Pet, Software, Tail, Veterinary medicine, Nucleosome, Mars Science Laboratory, Telehealth, Research and development, Dick, Diagnosis, Medical imaging, Vaccine, Research

WARWICK, England, 7 Nov. 2023 /PRNewswire/ -- Antech, the full-service veterinary diagnostics business that is part of the Science & Diagnostics division of Mars Petcare, today announced the opening of a new UK veterinary diagnostics laboratory in Warwick on 15 November. This expands Antech's UK lab network, which also includes Southfields Veterinary Specialists Diagnostic Laboratory and the Dick White Referrals Diagnostic Laboratory.

Key Points: 
  • Antech to offer UK veterinary professionals a complete and flexible diagnostics portfolio spanning reference labs, in-house diagnostics, imaging and software
    WARWICK, England, 7 Nov. 2023 /PRNewswire/ -- Antech, the full-service veterinary diagnostics business that is part of the Science & Diagnostics division of Mars Petcare, today announced the opening of a new UK veterinary diagnostics laboratory in Warwick on 15 November.
  • This expands Antech's UK lab network, which also includes Southfields Veterinary Specialists Diagnostic Laboratory and the Dick White Referrals Diagnostic Laboratory.
  • Antech, a trusted partner in delivering veterinary diagnostics for more than 35 years, brings to the UK a complete portfolio that spans reference laboratory services, in-house diagnostics, comprehensive imaging and technology solutions, advanced telemedicine services and innovative rapid diagnostics.
  • We are continuing to bring this vision to life by establishing a full-service veterinary diagnostics offering in the UK, which spans reference labs, in-house diagnostics, imaging and software solutions.

Antech launches first comprehensive veterinary diagnostics offering in the UK, including a new state-of-the-art reference laboratory

Retrieved on: 
Tuesday, November 7, 2023
Science, Cancer, Veterinarian, AIS, Mars, Incorporated, Head, Pet, Software, Tail, Veterinary medicine, Nucleosome, Mars Science Laboratory, Telehealth, Research and development, Dick, Diagnosis, Medical imaging, Vaccine, Research

WARWICK, England, 7 Nov. 2023 /PRNewswire/ -- Antech, the full-service veterinary diagnostics business that is part of the Science & Diagnostics division of Mars Petcare, today announced the opening of a new UK veterinary diagnostics laboratory in Warwick on 15 November. This expands Antech's UK lab network, which also includes Southfields Veterinary Specialists Diagnostic Laboratory and the Dick White Referrals Diagnostic Laboratory.

Key Points: 
  • Antech to offer UK veterinary professionals a complete and flexible diagnostics portfolio spanning reference labs, in-house diagnostics, imaging and software
    WARWICK, England, 7 Nov. 2023 /PRNewswire/ -- Antech, the full-service veterinary diagnostics business that is part of the Science & Diagnostics division of Mars Petcare, today announced the opening of a new UK veterinary diagnostics laboratory in Warwick on 15 November.
  • This expands Antech's UK lab network, which also includes Southfields Veterinary Specialists Diagnostic Laboratory and the Dick White Referrals Diagnostic Laboratory.
  • Antech, a trusted partner in delivering veterinary diagnostics for more than 35 years, brings to the UK a complete portfolio that spans reference laboratory services, in-house diagnostics, comprehensive imaging and technology solutions, advanced telemedicine services and innovative rapid diagnostics.
  • We are continuing to bring this vision to life by establishing a full-service veterinary diagnostics offering in the UK, which spans reference labs, in-house diagnostics, imaging and software solutions.

Measuring Nucleosomes Using Nu.Q® NETs is a Promising Biomarker for Septic Shock

Retrieved on: 
Thursday, October 19, 2023
Annals of Intensive Care, NYSE, Hospice, Intensive care medicine, Septic shock, Hospices Civils de Lyon, Human, Mortality, IL-6, Chromatin, Fungus, Virus, Pelvic floor dysfunction, Nucleosome, SAPS, Immune system, Animal, NETS, Cancer, SOFA, Sepsis, Patient, Death, Pharmaceutical industry, Veterinary medicine, Volition

Professor Monneret and his team used Volition's automated nucleosome quantification assay, Nu.Q® NETs, to measure nucleosome levels in patients with septic shock and to determine whether there is an association with mortality.

Key Points: 
  • Professor Monneret and his team used Volition's automated nucleosome quantification assay, Nu.Q® NETs, to measure nucleosome levels in patients with septic shock and to determine whether there is an association with mortality.
  • Nu.Q® NETs is a simple, low cost and routine blood test which can detect clinically elevated levels of NETs by identifying the unique biomarker H3.1.
  • Professor Guillaume Monneret, Head of Clinical Immunology Laboratory at Hospices Civils de Lyon, said:
    "This was the first study to investigate both nucleosomes and immunological parameters in septic shock.
  • We saw a significant elevation of nucleosomes in septic shock patients.

Volition Presents Three Cancer Detection Abstracts at ESMO 2023

Retrieved on: 
Monday, October 16, 2023
Diagnosis, Lung cancer, NYSE, Biomarker, Plasma, University, Volition, Cancer, Nucleosome, National Taiwan University Hospital, ESMO, Oncology, Université de Namur, Research institute, Clinical Trial Service Unit, Nucleic acid thermodynamics, European Society for Medical Oncology, CTCF, Glioblastoma, Malignancy, Poster, Nursing

HENDERSON, Nev., Oct. 16, 2023 /PRNewswire/ -- VolitionRx Limited (NYSE AMERICAN: VNRX) ("Volition"), a multi-national epigenetics company, is presenting three scientific abstracts at ESMO 2023, the annual congress of the European Society for Medical Oncology.

Key Points: 
  • HENDERSON, Nev., Oct. 16, 2023 /PRNewswire/ -- VolitionRx Limited (NYSE AMERICAN: VNRX) ("Volition"), a multi-national epigenetics company, is presenting three scientific abstracts at ESMO 2023, the annual congress of the European Society for Medical Oncology.
  • Dr. Jake Micallef, Chief Scientific Officer at Volition, said: "We are delighted to be attending ESMO 2023 and have the opportunity to share exciting new data in lung cancer and glioblastoma, and introduce what we believe to be an entirely new method for the detection of cancer."
  • On Saturday 21st October, Dr. Dorian Pamart, Head of Technology and Service Unit at Volition, will present a poster (205P) titled 'A novel immunoprecipitation/PCR method for detection of plasma cfDNA fragments selectively occupied by CTCF in cancer'.
  • The study was undertaken by Volition and the National Taiwan University Hospital and is part of a longer-term research collaboration.

Laureates of the 2023 WLA Prize Announced

Retrieved on: 
Thursday, September 14, 2023
DNA, Operation, Mathematics, DNA condensation, Georgia Tech, Emeritus, System, H. Milton Stewart School of Industrial and Systems Engineering, Crystallography, ETH, Prize, Chromatin, MRC Laboratory of Molecular Biology, WLA, Georgia Institute of Technology School of Computer Science, Research, International Journal of Biological Macromolecules, History, RMB, DNA replication, Machine learning, Algorithm, Engineering, Nucleosome, Computer science, Economics, Pharmaceutical industry, Management, Medical imaging, Microscope, Nesterov, Chemistry, Medicine, Physiology

Shanghai, Sept. 14, 2023 (GLOBE NEWSWIRE) -- The World Laureates Association Prize (WLA Prize) unveils its 2023 laureates on Thursday, at a press conference held in Shanghai.

Key Points: 
  • Shanghai, Sept. 14, 2023 (GLOBE NEWSWIRE) -- The World Laureates Association Prize (WLA Prize) unveils its 2023 laureates on Thursday, at a press conference held in Shanghai.
  • The 2023 WLA Prize in Computer Science or Mathematics recognizes two scientists: Arkadi Nemirovski, John P. Hunter, Jr.
  • The 2023 WLA Prize Award Ceremony is scheduled to take place in Shanghai on November 6, followed by a series of engaging sessions to celebrate the laureates' outstanding achievements.
  • The WLA Prize is an international science prize established in Shanghai, in 2021, initiated by the World Laureates Association (WLA), managed by the WLA Foundation, and exclusively funded by HongShan.

Kanazawa University research: Biomolecular sliding at the nanoscale

Retrieved on: 
Tuesday, February 28, 2023
Lens, Protein, DNA, Gene expression, Cell, AFM, Kanazawa University, Nano Letters, X-ray crystallography, Plant, Map, Embryo, Histone, Animal, Nucleosome, Microscope, Vaccine, H2A

KANAZAWA, Japan, Feb. 28, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nano Letters the discovery of a biomolecular dynamical process likely relevant to gene expression.

Key Points: 
  • KANAZAWA, Japan, Feb. 28, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nano Letters the discovery of a biomolecular dynamical process likely relevant to gene expression.
  • Mikihiro Shibata from Kanazawa University and colleagues have now succeeded in making video recordings of the nucleosome dynamics of H2A.Z, a histone variant associated with various biological processes.
  • Researchers at Kanazawa University have in recent years developed HS-AFM further, so that it can be applied to study biochemical molecules and biomolecular processes in real-time.
  • High-Speed Atomic Force Microscopy Reveals Spontaneous Nucleosome Sliding of H2A.Z at the Subsecond Time Scale, Nano Letters (2023).

Kanazawa University research: Biomolecular sliding at the nanoscale

Retrieved on: 
Tuesday, February 28, 2023
Lens, Protein, DNA, Gene expression, Cell, AFM, Kanazawa University, Nano Letters, X-ray crystallography, Plant, Map, Embryo, Histone, Animal, Nucleosome, Microscope, Vaccine, H2A

KANAZAWA, Japan, Feb. 28, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nano Letters the discovery of a biomolecular dynamical process likely relevant to gene expression.

Key Points: 
  • KANAZAWA, Japan, Feb. 28, 2023 /PRNewswire/ -- Researchers at Kanazawa University report in Nano Letters the discovery of a biomolecular dynamical process likely relevant to gene expression.
  • Mikihiro Shibata from Kanazawa University and colleagues have now succeeded in making video recordings of the nucleosome dynamics of H2A.Z, a histone variant associated with various biological processes.
  • Researchers at Kanazawa University have in recent years developed HS-AFM further, so that it can be applied to study biochemical molecules and biomolecular processes in real-time.
  • High-Speed Atomic Force Microscopy Reveals Spontaneous Nucleosome Sliding of H2A.Z at the Subsecond Time Scale, Nano Letters (2023).