Swiss Institute of Allergy and Asthma Research

Novel classification of allergic disorders published by the European Academy of Allergy and Clinical Immunology: SIAF

Retrieved on: 
Tuesday, October 10, 2023

DAVOS, Switzerland, Oct. 10, 2023 /PRNewswire/ -- The revision of the current allergic disease nomenclature based on symptoms and organ dysfunction has been long-awaited at the time of modern patient-tailored treatments and precision medicine. The new classification is based on disease mechanisms, thus facilitating targeted and personalised disease management.

Key Points: 
  • The new classification is based on disease mechanisms, thus facilitating targeted and personalised disease management.
  • The world's key opinion leaders gathered around the initiative of the European Academy of Allergy and Clinical Immunology (EAACI) to present a new classification of allergic disorders based on the mechanisms of diseases.
  • Published online today in Allergy, the position paper reveals the new way allergic diseases are perceived.
  • We expect the new classification to  profoundly change the healthcare professionals' approach to managing allergic diseases since it provides key solutions to a personalised approach.

Novel classification of allergic disorders published by the European Academy of Allergy and Clinical Immunology: SIAF

Retrieved on: 
Tuesday, October 10, 2023

DAVOS, Switzerland, Oct. 10, 2023 /PRNewswire/ -- The revision of the current allergic disease nomenclature based on symptoms and organ dysfunction has been long-awaited at the time of modern patient-tailored treatments and precision medicine. The new classification is based on disease mechanisms, thus facilitating targeted and personalised disease management.

Key Points: 
  • The new classification is based on disease mechanisms, thus facilitating targeted and personalised disease management.
  • The world's key opinion leaders gathered around the initiative of the European Academy of Allergy and Clinical Immunology (EAACI) to present a new classification of allergic disorders based on the mechanisms of diseases.
  • Published online today in Allergy, the position paper reveals the new way allergic diseases are perceived.
  • We expect the new classification to  profoundly change the healthcare professionals' approach to managing allergic diseases since it provides key solutions to a personalised approach.

SIAF: Disrupted epithelial barriers as a predictor of severe COVID-19 development

Retrieved on: 
Monday, July 10, 2023

DAVOS, Switzerland, July 10, 2023 /PRNewswire/ -- According to the epithelial barrier theory, disruption of epithelial barriers by environmental and toxic agents triggers microbial dysbiosis, bacterial translocation to subepithelial areas and local or systemic immune/inflammatory response to environmental agents, allergens and microbes. Such events have been implicated in the development of chronic conditions like allergic, autoimmune, and metabolic diseases, such as diabetes, obesity, rheumatoid arthritis, allergies, asthma, atopic dermatitis. In severe cases of COVID-19, characteristic features include hyperinflammation, hyperactivated immune responses (referred to as the cytokine storm), cellular infiltration, and organ damage.

Key Points: 
  • In severe cases of COVID-19, characteristic features include hyperinflammation, hyperactivated immune responses (referred to as the cytokine storm), cellular infiltration, and organ damage.
  • The compromised epithelial barriers in the mucosas, particularly in gut mucosa facilitates the translocation of microbiota and their secreted metabolites, thus initiating or exacerbating inflammatory cascades in many inflammatory diseases.
  • The research group of epithelial biology in the Swiss Institute of Allergy and Asthma Research, associated with the University of Zurich, has been working on epithelial barriers for more than 20 years.
  • The authors analyzed the amount of bacterial DNA leakage to circulation and showed the link between disrupted epithelial barriers and an excessive inflammatory response.

SIAF: Disrupted epithelial barriers as a predictor of severe COVID-19 development

Retrieved on: 
Monday, July 10, 2023

DAVOS, Switzerland  , July 9, 2023 /PRNewswire/ -- According to the epithelial barrier theory, disruption of epithelial barriers by environmental and toxic agents triggers microbial dysbiosis, bacterial translocation to subepithelial areas and local or systemic immune/inflammatory response to environmental agents, allergens and microbes. Such events have been implicated in the development of chronic conditions like allergic, autoimmune, and metabolic diseases, such as diabetes, obesity, rheumatoid arthritis, allergies, asthma, atopic dermatitis. In severe cases of COVID-19, characteristic features include hyperinflammation, hyperactivated immune responses (referred to as the cytokine storm), cellular infiltration, and organ damage.

Key Points: 
  • In severe cases of COVID-19, characteristic features include hyperinflammation, hyperactivated immune responses (referred to as the cytokine storm), cellular infiltration, and organ damage.
  • The compromised epithelial barriers in the mucosas, particularly in gut mucosa facilitates the translocation of microbiota and their secreted metabolites, thus initiating or exacerbating inflammatory cascades in many inflammatory diseases.
  • The research group of epithelial biology in the Swiss Institute of Allergy and Asthma Research, associated with the University of Zurich, has been working on epithelial barriers for more than 20 years.
  • The authors analyzed the amount of bacterial DNA leakage to circulation and showed the link between disrupted epithelial barriers and an excessive inflammatory response.

Seed Health and the Swiss Institute of Allergy and Asthma Research Launch Novel Immunology Platform to Develop the Next Generation of Microbiome and Barrier-Safe Personal Care Products

Retrieved on: 
Wednesday, January 18, 2023

LOS ANGELES and DAVOS, Switzerland, Jan. 18, 2023 /PRNewswire/ -- Seed Health, a microbiome science company, and the Swiss Institute of Allergy and Asthma Research (SIAF) today announced the launch of a new platform to develop the next generation of non-toxic, non-inflammatory, microbiome-safe home and personal care products.

Key Points: 
  • With the rise of industrialization and urbanization, 350,000 new chemicals have been introduced to "modern life" since 1950.
  • "Our platform uniquely combines host and microbial immunology to reimagine the future of products in the built environment."
  • Dr. Akdis has published over 520 peer-reviewed papers, many of which were foundational to the development of the EDAPS-I platform.
  • Ecological disruption is now mirrored in our health," said Ara Katz, Seed Health Co-Founder.

Commercial Dishwashers Destroy Protective Layer in Gut

Retrieved on: 
Thursday, December 1, 2022

ZURICH, Dec. 1, 2022 /PRNewswire/ -- Whether it's at a restaurant, at school or in the barracks, commercial dishwashers help plates, glasses and cutlery become squeaky clean and dry in a matter of minutes. These practical appliances come with risks, however, as was recently discovered in a new study by researchers at the Swiss Institute of Allergy and Asthma Research (SIAF), an associated institute of the University of Zurich (UZH). One ingredient in particular found in commercial rinse agents has a toxic effect on the gastrointestinal tract.

Key Points: 
  • This damages the natural protective layer in the gut and can contribute to the onset of chronic diseases, as demonstrated by researchers working with organoids at the Swiss Institute of Allergy and Asthma Research, an associated UZH institute.
  • One ingredient in particular found in commercial rinse agents has a toxic effect on the gastrointestinal tract.
  • A typical cycle in a commercial dishwasher involves circulating hot water and detergent for around 60 seconds at high pressure.
  • Akdis calls for an immediate response: "It is important to inform the public about this risk, since alcohol ethoxylates seem to be commonly used in commercial dishwashers."

Commercial Dishwashers Destroy Protective Layer in Gut

Retrieved on: 
Thursday, December 1, 2022

ZURICH, Dec. 1, 2022 /PRNewswire/ -- Whether it's at a restaurant, at school or in the barracks, commercial dishwashers help plates, glasses and cutlery become squeaky clean and dry in a matter of minutes. These practical appliances come with risks, however, as was recently discovered in a new study by researchers at the Swiss Institute of Allergy and Asthma Research (SIAF), an associated institute of the University of Zurich (UZH). One ingredient in particular found in commercial rinse agents has a toxic effect on the gastrointestinal tract.

Key Points: 
  • This damages the natural protective layer in the gut and can contribute to the onset of chronic diseases, as demonstrated by researchers working with organoids at the Swiss Institute of Allergy and Asthma Research, an associated UZH institute.
  • One ingredient in particular found in commercial rinse agents has a toxic effect on the gastrointestinal tract.
  • A typical cycle in a commercial dishwasher involves circulating hot water and detergent for around 60 seconds at high pressure.
  • Akdis calls for an immediate response: "It is important to inform the public about this risk, since alcohol ethoxylates seem to be commonly used in commercial dishwashers."

Nature article presents impact and importance of epithelial barrier damage on a range of common diseases

Retrieved on: 
Thursday, April 15, 2021

The article was written by Professor Cezmi Akdis at the Swiss institute of Allergy and Asthma Research (SIAF).

Key Points: 
  • The article was written by Professor Cezmi Akdis at the Swiss institute of Allergy and Asthma Research (SIAF).
  • Prof. Akdis is the key research collaborator in SciBase\'s product development for skin barrier assessment.
  • The article presents the background for the steep increase in allergic diseases over the last decades, and how this increase is connected to industrialization and modern lifestyle.\nSimon Grant, CEO of SciBasecommented, "This article shows just how important the skin and epithelial barrier in general, are in the development of a range of diseases.
  • The Nature article is impressive in its breadth and by extension what it can mean for SciBase\'s barrier assessment technology.

Nature article presents impact and importance of epithelial barrier damage on a range of common diseases

Retrieved on: 
Thursday, April 15, 2021

The article was written by Professor Cezmi Akdis at the Swiss institute of Allergy and Asthma Research (SIAF).

Key Points: 
  • The article was written by Professor Cezmi Akdis at the Swiss institute of Allergy and Asthma Research (SIAF).
  • Prof. Akdis is the key research collaborator in SciBase\'s product development for skin barrier assessment.
  • The article presents the background for the steep increase in allergic diseases over the last decades, and how this increase is connected to industrialization and modern lifestyle.\nSimon Grant, CEO of SciBasecommented, "This article shows just how important the skin and epithelial barrier in general, are in the development of a range of diseases.
  • The Nature article is impressive in its breadth and by extension what it can mean for SciBase\'s barrier assessment technology.

Sino Agro Food Posts Brokerage Procedures for Merkur Delisting

Retrieved on: 
Thursday, August 29, 2019

GUANGZHOU, China, Aug. 28, 2019 /PRNewswire/ -- Sino Agro Food, Inc. (OTCQX: SIAF) (OSE: SIAF-ME), a company focused on high protein food including seafood and cattle ("SIAF"), previously reported that it would delist from the Merkur market in Oslo.

Key Points: 
  • GUANGZHOU, China, Aug. 28, 2019 /PRNewswire/ -- Sino Agro Food, Inc. (OTCQX: SIAF) (OSE: SIAF-ME), a company focused on high protein food including seafood and cattle ("SIAF"), previously reported that it would delist from the Merkur market in Oslo.
  • SIAF contacted the main brokerage companies that its Scandinavian shareholders use, and has posted information learned regarding recommended procedures shareholders can elect before SIAF's shares are delisted at the Merkur Market: