Mesenchymal stem cell

Incubation with Extracellular Vesicles Boosts Cells' Grafting Ability

Retrieved on: 
Tuesday, June 11, 2019
Branches of biology, Biology, Cell biology, Stem cells, Mesenchymal stem cell, CD34, Stem cell, Extracellular vesicle, Adult stem cell, Stem cell transplantation for articular cartilage repair

DURHAM, N.C., June 11, 2019 /PRNewswire-PRWeb/ -- A study released today in STEM CELLS demonstrates how extracellular vesicles derived from human mesenchymal stem cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying their gene expression and increasing their viability and cloning ability.

Key Points: 
  • DURHAM, N.C., June 11, 2019 /PRNewswire-PRWeb/ -- A study released today in STEM CELLS demonstrates how extracellular vesicles derived from human mesenchymal stem cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying their gene expression and increasing their viability and cloning ability.
  • In a test on mice, MSC-EVs also increased the cells' ability to lodge into bone marrow.
  • "In the current work, we wanted to evaluate the changes induced in CD34+ cells after the incorporation of MSC-derived EV.
  • Moreover, we have assessed if this incorporation has functional implications, evaluating their clonogenic ability in vitro and the in vivo engraftment in a mouse model."

RoosterBio and Tissue Regeneration Therapeutics Collaborate to Make Human Umbilical Cord-Derived MSC Bioprocess Systems Broadly Available

Retrieved on: 
Wednesday, May 29, 2019
Stem cells, Branches of biology, Biology, Life sciences, Regenerative medicine, Umbilical cord, Mesenchymal stem cell, Stem-cell therapy

This collaboration will productize TRT's core technology around human umbilical cord-derived mesenchymal stem/stromal cells (hUC-MSCs) to the entire Regenerative Medicine marketplace.

Key Points: 
  • This collaboration will productize TRT's core technology around human umbilical cord-derived mesenchymal stem/stromal cells (hUC-MSCs) to the entire Regenerative Medicine marketplace.
  • Within the terms of the agreement, RoosterBio obtains an exclusive worldwide license to TRT's patent estate related to the manufacture and global sale of human umbilical cord-derived MSCs.
  • "We are excited to collaborate with Tissue Regeneration Therapeutics to bring their cord-derived cell technologies to the broader Regenerative Medicine market," said Margot Connor, RoosterBio's CEO.
  • RoosterBio's products are high-volume, affordable, and well-characterized adult human mesenchymal stem/stromal cells (hMSCs) paired with highly engineered media systems.

SanBio: SB623, an Investigational Product, Granted Advanced Therapy Medicinal Product Classification by European Medicines Agency

Retrieved on: 
Thursday, April 25, 2019
Stem cells, Health, Biotechnology, Clinical trials, Pharmaceutical, Professional services, Finance, Stem cells, Life sciences, Biotechnology, Pharmaceutical industry, Biology, European Medicines Agency, European Union, Mesenchymal stem cell, Medication

Advanced therapy medicinal products(ATMPs) are medicines for human use that are based on genes, tissues or cells.

Key Points: 
  • Advanced therapy medicinal products(ATMPs) are medicines for human use that are based on genes, tissues or cells.
  • Determined by the Committee for Advanced Therapies (CAT) at the European Medicines Agency (EMA), treatments that receive ATMP classification may offer groundbreaking new opportunities for the treatment of disease and injury.1
    SB623 is an investigational product made from modified and cultured adult bone marrow-derived mesenchymal stem cells that undergo temporary genetic modification.
  • We hope this ATMP classification allows us the opportunity to work closely with European regulators around the development and regulatory pathway for SB623.
  • On April 16, SanBio presented positive Phase 2 results from the STEMTRA trial at the American Association of Neurological Surgeons (AANS) annual scientific meeting.

Stem Cell Therapy in Las Vegas Offered By Ageless Forever

Retrieved on: 
Wednesday, April 24, 2019
Branches of biology, Biology, Life sciences, Stem cells, Biotechnology, Emerging technologies, Cell biology, Regenerative biomedicine, Stem-cell therapy, Regenerative medicine, Mesenchymal stem cell, Cell therapy

LAS VEGAS, April 24, 2019 /PRNewswire/ --Ageless Forever is pleased to announce it now offers Stem Cell Therapy to assist one's body's ability to heal itself on a cellular level.

Key Points: 
  • LAS VEGAS, April 24, 2019 /PRNewswire/ --Ageless Forever is pleased to announce it now offers Stem Cell Therapy to assist one's body's ability to heal itself on a cellular level.
  • Regenerative Stem Cell Therapy is a procedure in which Mesenchymal stem cells are extracted from the placenta and are then injected into the injury or affected area.
  • The most ideal parts of the body to use stem cell therapy is the shoulder, elbow, hand and wrist, knee, lower spine, and hip.
  • Pierce, Medical Director of Ageless Forever , is board certified in American College of Osteopathic Emergency Physicians (ACOEP) and American Board of Anti-aging and Regenerative Medicine.

Scientists Define the Role for a Rare, Influential Set of Bone Marrow Cells

Retrieved on: 
Tuesday, April 23, 2019
Branches of biology, Biology, Stem cells, Mesenchymal stem cell, Osteoblast, Bone, Adipocyte, Precursor cell, Muse cell, Induced stem cells

Such cells are thought to influence whether early stem cells mature into different types of other cells, such as red or white blood cells.

Key Points: 
  • Such cells are thought to influence whether early stem cells mature into different types of other cells, such as red or white blood cells.
  • Reporting in the journal Nature online in April, the study authors describe how they used a combined imaging-mapping tool to track the genetic function one by one of 17,374 mouse bone marrow cells.
  • Most were identified as cells that line blood vessels (i.e., vascular endothelial cells) or stem cells (mesenchymal cells) that make up bone (osteoblasts).
  • Among the stress-induced changes was that one set of stem cells (also mesenchymal), which typically develop into osteoblasts or muscle cells, in this instance only turned into fat cells (adipocytes).

SanBio Announces SB623 Regenerative Cell Therapy for Traumatic Brain Injury Has Received Ministry of Health, Labour and Welfare (MHLW) Sakigake Designation

Retrieved on: 
Monday, April 8, 2019
Stem cells, Health, Biotechnology, Clinical trials, Pharmaceutical, Branches of biology, Biology, Life sciences, Stem cells, Biotechnology, Regenerative biomedicine, Emerging technologies, Induced stem cells, Mesenchymal stem cell, Regenerative medicine

The Sakigake Designation System targets regenerative medicines that treat serious diseases which urgently require innovative therapies.

Key Points: 
  • The Sakigake Designation System targets regenerative medicines that treat serious diseases which urgently require innovative therapies.
  • SanBios proprietary regenerative cell medicine SB623, which has been granted the Sakigake Designation, is made from modified and cultured adult bone marrow-derived mesenchymal stem cells that undergo temporary genetic modification.
  • Implantation of SB623 cells into injured nerve tissue in the brain is expected to trigger the brains natural regenerative ability to recover lost motor functions.
  • SanBio Medical Director and Head of Development / Japan, Takehiko Kaneko, commented: We are delighted that the TBI program for SB623 has received the Sakigake Designation.

Dr. David Capaldi - Chief Medical Officer at the Rejuva Stem Cell Clinic - is the Keynote Speaker at the 2nd Global Tissue Engineering, Regenerative Medicine, and Stem Cell Conference Being Held in Amsterdam March 2019

Retrieved on: 
Thursday, March 7, 2019
Branches of biology, Biology, Stem cells, Life sciences, Stem-cell therapy, Cord blood, Mesenchymal stem cell, Regenerative medicine, Cell therapy, Adult stem cell, Stem-cell line

Rejuva Stem Cell Clinic specializes in umbilical cord blood-derived stem cell therapy.

Key Points: 
  • Rejuva Stem Cell Clinic specializes in umbilical cord blood-derived stem cell therapy.
  • Therefore, our team of experts at Rejuva Stem Cell Clinic offers unprecedented stem cell therapy that has already benefited hundreds of patients.
  • At this year's 2nd Global Regenerative Medicine Conference, Dr. Capaldi will discuss human umbilical cord mesenchymal stem cells, particularly those that are derived from the cord blood.
  • Dr. Capaldi has trained hundreds of regenerative medicine doctors in proper stem cell injection techniques and we congratulate Dr. Capaldi on being chosen as the Keynote Speaker at this year's Regenerative Medicine Conference.

Maintaining the Utility of Stem Cells in Tissue Engineering

Retrieved on: 
Thursday, February 7, 2019
Branches of biology, Biology, Life sciences, Stem cells, Biotechnology, Developmental biology, Induced stem cells, Cell biology, Adult stem cell, Mesenchymal stem cell, Tissue engineering, Cellular differentiation

WASHINGTON, Feb. 7, 2019 /PRNewswire/ --An article published in Experimental Biology and Medicine (Volume 244, Issue 1, January, 2019) ( https://journals.sagepub.com/doi/pdf/10.1177/1535370218821063 ) provides an alternative approach for maintaining the usefulness of stem cells in tissue engineering.

Key Points: 
  • WASHINGTON, Feb. 7, 2019 /PRNewswire/ --An article published in Experimental Biology and Medicine (Volume 244, Issue 1, January, 2019) ( https://journals.sagepub.com/doi/pdf/10.1177/1535370218821063 ) provides an alternative approach for maintaining the usefulness of stem cells in tissue engineering.
  • Bone marrow mesenchymal stem cells (BMSCs) are adult stem cells that are capable of rapid proliferation and differentiation into multiple types of cells.BMSCs are also less immunogenic and tumorogenic than some other types of stem cells.
  • Nonetheless, the use of BMSCs in tissue engineering is jeopardized by their tendency to spontaneously differentiate when cultured in vitro.
  • Thus, identifying strategies that prevent differentiation and maintain BMSC stemness is a high priority for tissue engineering.

Stem Cells Could Prevent Tissue Damage Caused by Radiotherapy

Retrieved on: 
Monday, November 19, 2018
Biology, Stem cells, Biotechnology, Nature, Cell biology, Mesenchymal stem cell, Radiation therapy, Adult stem cell, Clinical uses of mesenchymal stem cells

DURHAM, N.C., Nov. 19, 2018 /PRNewswire-PRWeb/ -- A new study in STEM CELLS Translational Medicine indicates mesenchymal stem cells (MSCs) are a safe and innovative option to heal normal tissue following radiotherapy.

Key Points: 
  • DURHAM, N.C., Nov. 19, 2018 /PRNewswire-PRWeb/ -- A new study in STEM CELLS Translational Medicine indicates mesenchymal stem cells (MSCs) are a safe and innovative option to heal normal tissue following radiotherapy.
  • However, radiotherapy can cause substantial damage to a patient's normal tissue.
  • Mesenchymal stem cells (MSCs) have been used to help alleviate this damage, but their potential to lead to residual tumor cells is worrisome.
  • About STEM CELLS Translational Medicine: STEM CELLS Translational Medicine (SCTM), published by AlphaMed Press, is a monthly peer-reviewed publication dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology.

Positive Results of Orthopedic Treatment With the Use of ApoGraft™ Enriched Stem Cells Derived From Fat Tissues

Retrieved on: 
Thursday, October 18, 2018
Biology, Stem cells, Medicine, Biotechnology, Bone marrow, Mesenchymal stem cell, Hematopoietic stem cell transplantation, Bone, Stem-cell therapy, Adult stem cell

The study used ApoGraft enriched human mesenchymal stem cells at the time of surgery with the aim of improving the post-surgery healing process.

Key Points: 
  • The study used ApoGraft enriched human mesenchymal stem cells at the time of surgery with the aim of improving the post-surgery healing process.
  • Until this study, ApoGraft was mainly used on blood cells (hematopoietic) and, in studies to date, has proven to be beneficial in stem cells selection of bone marrow (including for treatment of cancer by Bone marrow transplantation, and autoimmune diseases).
  • The new study has shown beneficial effect of the Apograft treated cells in an orthopedic model.
  • For example, forward-looking statements are used in this press release when we discuss future potential uses of Apograft for orthopedic indications.