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RIBOMIC Phase I and II Data Published in the Eye: Full TOFU/RAMEN/TEMPURA Trial Results Demonstrate Clinical Proof of Concept of Umedaptanib Pegol in Exudative Age-Related Macular Degeneration (nAMD)

Retrieved on: 
Tuesday, December 5, 2023

TEMPURA is an investigator-sponsored, single-center, open-label, 4-month study of umedaptanib pegol in five treatment-naïve nAMD patients.

Key Points: 
  • TEMPURA is an investigator-sponsored, single-center, open-label, 4-month study of umedaptanib pegol in five treatment-naïve nAMD patients.
  • Throughout these studies umedaptanib pegol was safe, well tolerated, and effective to treat nAMD patients with no or short history of anti-VEGF treatment.
  • In nAMD patients with a long history of anti-VEGF treatment, umedaptanib pegol showed no additional benefit of monotherapy or the combination over Eylea®.
  • Notably, visual acuity decreased slightly in patients who switched from anti-VEGF (Eylea®) to umedaptanib pegol in the RAMEN study.

AstraZeneca launches Evinova, a health-tech business to accelerate innovation across the life sciences sector, the delivery of clinical trials and better health outcomes

Retrieved on: 
Monday, November 20, 2023

The technologies have already been used in the successful delivery of multiple AstraZeneca-sponsored clinical trials in over 40 countries.

Key Points: 
  • The technologies have already been used in the successful delivery of multiple AstraZeneca-sponsored clinical trials in over 40 countries.
  • The suite includes:
    Evinova unified trial solution: A global GxP-validated solution for patients, clinical trial site staff and clinical trial sponsor staff to improve delivery of clinical trials.
  • It enables the delivery of traditional, hybrid and decentralised clinical trials while enhancing the patient experience.
  • Evinova is a health-tech business, accelerating the delivery of better health outcomes by propelling the life sciences sector forward in digital health, from the inside.

The euro area bank lending survey – Fourth quarter of 2022

Retrieved on: 
Saturday, February 4, 2023

= Introduction =

Key Points: 
  • = Introduction =
    The results reported in the January 2023 bank lending survey (BLS) relate to changes observed during the fourth quarter of 2022 and expectations for the first quarter of 2023.
  • In addition to results for the euro area as a whole, this report also contains results for the four largest euro area countries.
  • = 1 Overview of results =
    In the January 2023 BLS, euro area banks reported a substantial further tightening of credit standards for loans or credit lines to enterprises in the fourth quarter of 2022, i.e.
  • In the first quarter of 2023, euro area banks expect a net tightening of a similar magnitude to the current quarter.
  • In more detail, euro area banks reported a substantial further tightening of their credit standards (i.e.
  • Banks’ cost of funds and balance sheet situation also continued to have a tightening impact on credit standards for loans to euro area firms.
  • In the first quarter of 2023, euro area banks expect a net tightening of similar magnitudes to the current quarter (24%).
  • Credit standards for loans to enterprises tightened in net terms in all four largest euro area countries in the fourth quarter of 2022 (see Overview table).
  • Firms’ net demand for loans decreased in the fourth quarter of 2022 (net percentage of -11%, after 13% in Q3 2022; see Overview table).
  • Net demand for both housing loans and consumer credit decreased in all four largest euro area countries.
  • Euro area banks reported that their access to retail funding and securitisation deteriorated moderately in the fourth quarter of 2022, while access to debt securities and money markets improved to a small extent.
  • Over the next six months, euro area banks expect a net tightening of credit standards across all main sectors of economic activity.
  • *Box 1 *General notes
    The bank lending survey (BLS) is addressed to senior loan officers at a representative sample of euro area banks.
  • In the current round, 151 banks were surveyed, representing all euro area countries and reflecting the characteristics of their respective national banking structures.
  • The main purpose of the BLS is to enhance the Eurosystem’s knowledge of bank lending conditions in the euro area.
  • The responses of the individual banks participating in the BLS are aggregated in two steps to form the euro area results.
  • In the first step, the responses of individual banks are aggregated to national results for the euro area countries.
  • It has been applied to all euro area and national BLS results in the current BLS questionnaire, including backdata.
  • In the assessment of survey balances for the euro area, net percentages between -1 and +1 are generally referred to as “broadly unchanged”.
  • = 2 Developments in credit standards, terms and conditions, and net demand for loans in the euro area = Euro area banks reported a substantial further tightening of credit standards for loans or credit lines to enterprises in the fourth quarter of 2022, i.e.
  • In the first quarter of 2023, euro area banks expect a net tightening of credit standards for loans to firms of a similar magnitude to the current quarter (24%).
  • Across the largest euro area countries, banks reported that in net terms the share of rejected loan applications increased in all four largest euro area countries.
  • According to euro area banks, firms’ net demand for loans decreased in the fourth quarter of 2022 (net percentage of -11%, after 13% in Q3 2022; see Chart 5).
  • Across all four largest euro area countries, credit standards for loans to households for house purchase tightened in net terms.
  • This is consistent with the recently observed slowdown in the rate of growth of house prices in the euro area.
  • In the first quarter of 2023, euro area banks again expect a net tightening of credit standards for consumer credit and other lending to households (net percentage of 15%).
  • Across all four largest euro area countries, overall terms and conditions for consumer credit and other lending to households tightened in net terms.

New Studies Demonstrate Benefits of Using Preoperative Planning and Navigation in Shoulder Surgery

Retrieved on: 
Monday, January 9, 2023

Exactech , a developer and producer of innovative implants, instrumentation, and smart technologies for joint replacement surgery, announces publication of two new studies that show positive clinical outcomes using the Equinoxe® shoulder preoperative Planning App and ExactechGPS® shoulder intraoperative navigation system.

Key Points: 
  • Exactech , a developer and producer of innovative implants, instrumentation, and smart technologies for joint replacement surgery, announces publication of two new studies that show positive clinical outcomes using the Equinoxe® shoulder preoperative Planning App and ExactechGPS® shoulder intraoperative navigation system.
  • View the full release here: https://www.businesswire.com/news/home/20230109005536/en/
    New Studies Demonstrate Benefits of Using Preoperative Planning and Navigation in Shoulder Surgery (Photo: Business Wire)
    The first new study, Implications of Navigation System Use for Glenoid Component Placement in Reverse Shoulder Arthroplasty1 (Kida H et al.
  • The study demonstrated that GPS navigation provided surgeons greater control and helped them more accurately and precisely reproduce their preoperative plan.
  • Accuracy and precision of placement of the glenoid baseplate in reverse total shoulder arthroplasty using a novel computer assisted navigation system combined with preoperative planning: A controlled cadaveric study.

Bing Crosby's Winter Wonderland Comes to Life in the Metaverse

Retrieved on: 
Friday, December 16, 2022

Bing Crosby's Winter Wonderland presents an amusement park within Decentraland that features a love letter to the aesthetic of a classic Bing Crosby Christmas.

Key Points: 
  • Bing Crosby's Winter Wonderland presents an amusement park within Decentraland that features a love letter to the aesthetic of a classic Bing Crosby Christmas.
  • Decentraland citizens will be able to buy Bing Crosby virtual Christmas Sweatshirts for their avatars to wear.
  • The Winter Wonderland experience brings to life Bing Crosby's iconic aesthetic that millions of folks think of when they think of the Christmas season.
  • Gather with digital community this December in Decentraland to experience Bing Crosby's Winter Wonderland.