Immunity

Whooping cough is surging in Australia. Why, and how can we protect ourselves?

Retrieved on: 
Friday, April 5, 2024

Cases are highest in Queensland and New South Wales, with more than 1,000 recorded in each state.

Key Points: 
  • Cases are highest in Queensland and New South Wales, with more than 1,000 recorded in each state.
  • The last time Queensland recorded more than 1,000 cases in three months was the first quarter of 2013.
  • So what is whooping cough, why are cases rising now, and how can you protect yourself?

It’s most dangerous for babies

  • The initial symptoms of whooping cough resemble other cold and flu-like symptoms.
  • However, as the disease progresses into the second week, the coughing fits become worse and more frequent.
  • After or between bouts of coughing, patients may gasp for air and produce the characteristic “whoop” noise.
  • Immunity from these vaccines wanes over time, so it’s also recommended adults receive a booster, particularly those who may come into frequent contact with babies.

Why are cases rising now?

  • Due to COVID measures such as border closures, social isolation and masks, the number of cases declined dramatically during 2020–23.
  • In Australia, cases have been particularly high during this outbreak in children aged 10–14.

A potential superbug

  • Most vaccines used in Australia and other developed countries stimulate your immune system to recognise and target three to five components of the bacteria.
  • These mutations make the bacteria look slightly different to the one used in the vaccine, helping it better hide from the immune system.
  • But in 2008, a new strain appeared in Australia that no longer produced pertactin, one of the components targeted by the vaccine.
  • This means your immune system, like a detective, has one less clue to recognise the bacteria.
  • Read more:
    Low vaccination and immunity rates mean NZ faces a harsh whooping cough winter – what needs to happen

What next?

  • Greater tracking of whooping cough strains, like we do with COVID, is needed to inform future vaccine design and treatments.
  • Importantly, although the bacteria is evolving, current vaccines are still very effective at preventing serious disease and reducing transmission.


Laurence Don Wai Luu does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

How Trump’s lawyers would fail my constitutional law class with their Supreme Court brief on criminal immunity

Retrieved on: 
Wednesday, April 3, 2024

On March 19, 2024, Trump filed his brief with the U.S. Supreme Court in the case brought by special counsel Jack Smith for Trump’s alleged criminal attempts to overturn the 2020 election.

Key Points: 
  • On March 19, 2024, Trump filed his brief with the U.S. Supreme Court in the case brought by special counsel Jack Smith for Trump’s alleged criminal attempts to overturn the 2020 election.
  • To support his contention, Trump cites Supreme Court cases, the Federalist Papers, and other writings from legal scholars.
  • If a student of mine had submitted a brief making the arguments that Trump and his lawyers assert in their Supreme Court filing, I would have given them an F.

Sitting in judgment

  • But it is not standard practice to characterize those cases and documents as saying one thing when they say the complete opposite.
  • Trump begins by citing Marbury v. Madison from 1803, which is one of the court’s most consequential cases.
  • Trump also argues that, according to the Constitution, “federal courts cannot sit in judgment directly over the President’s official acts.” This assertion is contrary to scores of cases where federal courts have reviewed presidential acts.
  • That act grants the secretary of education the authority to “waive or modify” student loan programs during national emergencies.

Citing Kavanaugh

  • But the main legal question remains – whether a president holds, as Trump claims, absolute immunity from criminal investigations and prosecutions for a president’s official acts.
  • From a policy perspective, Trump claims that “functional considerations” warrant the absolute immunity that he seeks because if a president is subject to criminal liability, that legal exposure “will cripple … Presidential decisionmaking.”
  • To further this claim, Trump relies on a 2009 law review article by Judge Brett Kavanaugh, then of the U.S. Court of Appeals for the District of Columbia Circuit, who now sits on the Supreme Court.
  • Trump quotes Kavanaugh, who wrote that “a President who is concerned about an ongoing criminal investigation is almost inevitably going to do a worse job as President,” which Trump provides as evidence of support for the position that a president requires absolute immunity.
  • But even a cursory reading of Kavanaugh’s article reveals that Kavanaugh argued only for a deferral of a criminal prosecution until after a president leaves office.

Civil cases vs. criminal cases

  • Trump urges the court to extend the presidential immunity established in this civil case to criminal matters.
  • But he overlooks the fundamental difference between the civil justice system and the criminal justice system.
  • The purpose of the civil justice system is to make an injured party whole again.
  • But the purpose of the criminal justice system is to protect society, because crimes are understood to be harms against the public.


Wayne Unger does not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

QED Secures $3 Million in Funding to Propel Fully Trustless Zero-Knowledge Applications Across the Bitcoin Ecosystem

Retrieved on: 
Tuesday, February 27, 2024

Decentralized applications built on QED can locally prove transactions, providing users with unlimited computation for a fixed gas fee.

Key Points: 
  • Decentralized applications built on QED can locally prove transactions, providing users with unlimited computation for a fixed gas fee.
  • "Bitcoin has traditionally lagged behind other blockchain protocols due to its lack of support for smart contracts and decentralized applications.
  • "We're pioneering a new frontier for decentralized applications that can take advantage of the liquidity of $1.01 trillion and growing Bitcoin market cap."
  • "We thrive on supporting exceptional teams and QED stands out as one that will accomplish much for the Web3 ecosystem.

Singaporeans are Armouring Up Against Viral Infections and Diseases with LAC's Immunity Arsenal

Retrieved on: 
Monday, March 4, 2024

In Singapore, while most citizens have established "the new normal", the upward trend of COVID-19 is still a pressing issue.

Key Points: 
  • In Singapore, while most citizens have established "the new normal", the upward trend of COVID-19 is still a pressing issue.
  • Occurrences of Tuberculosis have also been regular, with active cases constantly being detected through the country's National TB Programme.
  • The pressing issue about contracting such respiratory diseases is the lasting effects that it creates, even after the patient has recovered.
  • The possibilities of patients having recurring illnesses when their immunity weakens also poses a potential threat to the nation's overall wellbeing.

NCLA Asks Supreme Court to Revisit 120-year-old Precedent that Led to Rights Abuses Amid Pandemic

Retrieved on: 
Monday, March 11, 2024

MSU fired two of NCLA’s three clients, all of whom had naturally acquired immunity to Covid, for refusing the vaccine.

Key Points: 
  • MSU fired two of NCLA’s three clients, all of whom had naturally acquired immunity to Covid, for refusing the vaccine.
  • NCLA further urges the Court to hold that MSU’s policy failed to meet that standard.
  • NCLA’s petition presents the Supreme Court with an ideal opportunity to correct this widespread misunderstanding before another emergency pandemic breaks out.
  • The Court needs to update the precedent to reflect current constitutional law.”
    “CDC’s flawed guidance was not subject to direct court challenge, because it was deemed mere guidance.

iTeos Reports Fourth Quarter and Full Year 2023 Financial Results and Provides Business Updates

Retrieved on: 
Wednesday, March 6, 2024

WATERTOWN, Mass. and GOSSELIES, Belgium, March 06, 2024 (GLOBE NEWSWIRE) -- iTeos Therapeutics, Inc. (Nasdaq: ITOS), a clinical-stage biopharmaceutical company pioneering the discovery and development of a new generation of immuno-oncology therapeutics for patients, today reported financial results for the fourth quarter and full year ended December 31, 2023 and provided a business update.

Key Points: 
  • and GOSSELIES, Belgium, March 06, 2024 (GLOBE NEWSWIRE) -- iTeos Therapeutics, Inc. (Nasdaq: ITOS), a clinical-stage biopharmaceutical company pioneering the discovery and development of a new generation of immuno-oncology therapeutics for patients, today reported financial results for the fourth quarter and full year ended December 31, 2023 and provided a business update.
  • “With the recent developments in the TIGIT field, we believe belrestotug is in an advantageous position and are excited for its future prospects.
  • We look forward to sharing updates from our Phase 2 trials focused on 1L NSCLC and 1L HNSCC in 2024.
  • On December 7, 2023, iTeos announced the appointment of David K. Lee to the Company’s Board of Directors.

MariMed’s Betty’s Eddies™ Introduces Ache Away Eddies PM For Those Who Chews A Pain-Free Night’s Sleep

Retrieved on: 
Monday, March 4, 2024

NORWOOD, Mass., March 04, 2024 (GLOBE NEWSWIRE) -- Betty’s Eddies ™, the all-natural cannabis fruit chews handcrafted to fit a variety of needs, has launched a new flavor for consumers who want a pain-free, deep sleep: Ache Away Eddies PM.

Key Points: 
  • NORWOOD, Mass., March 04, 2024 (GLOBE NEWSWIRE) -- Betty’s Eddies ™, the all-natural cannabis fruit chews handcrafted to fit a variety of needs, has launched a new flavor for consumers who want a pain-free, deep sleep: Ache Away Eddies PM.
  • Ache Away Eddies PM may help ease inflammation and provide a restful night’s sleep by combining full spectrum cannabis with the most effective supporting cannabinoids and herbal supplements found in two of Betty’s Eddies best-selling fruit chews, Bedtime Betty's and Ache Away Eddies.
  • The blend of organic fruits and vegetables, CBN, CBC, Chamomile, Turmeric, and Piperine means sleeping is no longer a pain for those who chews the fast-acting and orange creme-flavored Ache Away Eddies PM.
  • Consumers can visit the Store Locator at www.bettyseddies.com to see where they can purchase Ache Away Eddies PM and the entire Betty’s Eddies line-up.

CENTOGENE Collaborates on Research Published in Science Showing Immunopathological Landscape of Human Pre-TCRα Deficiency

Retrieved on: 
Thursday, February 29, 2024

The study revealed that complete pre-TCRα deficiency is rare in humans and less severe than anticipated.

Key Points: 
  • The study revealed that complete pre-TCRα deficiency is rare in humans and less severe than anticipated.
  • Prof. Peter Bauer, Chief Medical and Genomic Officer at CENTOGENE, said, "This research advances our understanding of pre-TCRα deficiency significantly.
  • In analyzing genomic and phenomic data, CENTOGENE researchers helped establish the association between partial pre-TCRα deficiency and autoimmunity, with a higher prevalence than initially expected.
  • Christian Beetz, Senior Director Genomic Innovation at CENTOGENE, added, “Until now, the impact of pre-TCRα deficiency has been largely unknown.

GeoVax Reports 2023 Year-End Financial Results and Provides Business Update

Retrieved on: 
Thursday, February 29, 2024

ATLANTA, GA, Feb. 29, 2024 (GLOBE NEWSWIRE) -- via NewMediaWire – GeoVax Labs, Inc. (Nasdaq: GOVX), a biotechnology company developing immunotherapies and vaccines against cancers and infectious diseases, today announced its financial results and key operational accomplishments for the year ended December 31, 2023.

Key Points: 
  • ET
    ATLANTA, GA, Feb. 29, 2024 (GLOBE NEWSWIRE) -- via NewMediaWire – GeoVax Labs, Inc. (Nasdaq: GOVX), a biotechnology company developing immunotherapies and vaccines against cancers and infectious diseases, today announced its financial results and key operational accomplishments for the year ended December 31, 2023.
  • Results to date have demonstrated safety of this therapy and consistent reduction in treated tumors.
  • Cash Position: GeoVax reported cash balances of $6.5 million on December 31, 2023, as compared to $27.6 on December 31, 2022.
  • ET today, February 29, 2024, to review financial results and provide an update on corporate developments.

OPKO Health Reports Fourth Quarter 2023 Business Highlights and Financial Results

Retrieved on: 
Tuesday, February 27, 2024

MIAMI, Feb. 27, 2024 (GLOBE NEWSWIRE) -- OPKO Health, Inc. (NASDAQ: OPK) reports business highlights and financial results for the three and 12 months ended December 31, 2023.

Key Points: 
  • MIAMI, Feb. 27, 2024 (GLOBE NEWSWIRE) -- OPKO Health, Inc. (NASDAQ: OPK) reports business highlights and financial results for the three and 12 months ended December 31, 2023.
    Business highlights from the fourth quarter and subsequent weeks included the following:
    ModeX advanced its antiviral and immune-oncology product pipeline.
  • Operating loss was $16.0 million in the fourth quarter of 2023 compared with $22.0 million in the fourth quarter of 2022.
  • Total costs and expenses for the fourth quarter of 2023 were $166.4 million compared with $162.5 million in the fourth quarter of 2022.
  • Operating loss for the fourth quarter of 2023 was $69.1 million compared with an operating loss of $55.3 million for the 2022 quarter.