Mitochondrial DNA

 Precision BioSciences Announces New Study Published in Nature Communications Using Engineered ARCUS Nuclease to Target Mutant Mitochondrial DNA In Vivo

Retrieved on: 
Tuesday, June 1, 2021
Research, Genetics, Clinical trials, Biotechnology, Health, Pharmaceutical, General Health, Science, Oncology, Branches of biology, DNA, Mitochondrial genetics, Biology, Mitochondria, Mutation, Genetic genealogy, Mitochondrial DNA, Mitochondrion, Heteroplasmy, Genome editing, Threshold expression, ARCUS, Precision BioSciences, Inc., ARCUS, PRECISION BIOSCIENCES, INC.

Additionally, both mutant and wild-type mtDNA can co-exist within the mitochondria of a cell, a phenomenon called mtDNA heteroplasmy.

Key Points: 
  • Additionally, both mutant and wild-type mtDNA can co-exist within the mitochondria of a cell, a phenomenon called mtDNA heteroplasmy.
  • When specific threshold levels of mutant mtDNA are reached, cell function can be compromised, and disease can manifest1.
  • In this study, a mitochondrial-targeted ARCUS nuclease (mitoARCUS) used to edit mutant mtDNA was particularly effective, in part because of the nucleases small size and single protein nature.
  • Precision BioSciences, Inc. is a clinical stage biotechnology company dedicated to improving life (DTIL) with its wholly proprietary ARCUS genome editing platform.

Reneo Pharmaceuticals to Present at the Jefferies Virtual Healthcare Conference

Retrieved on: 
Wednesday, May 19, 2021
Branches of biology, Cellular respiration, Mitochondrion, Mitochondrial disease, Beta oxidation, Adenosine triphosphate, Acyl-CoA, Mitochondrial DNA

b'Reneo is a clinical stage pharmaceutical company focused on the development and commercialization of therapies for patients with rare genetic mitochondrial diseases, which are often associated with the inability of mitochondria to produce adenosine triphosphate (ATP).

Key Points: 
  • b'Reneo is a clinical stage pharmaceutical company focused on the development and commercialization of therapies for patients with rare genetic mitochondrial diseases, which are often associated with the inability of mitochondria to produce adenosine triphosphate (ATP).
  • Reneo is developing REN001 to modulate genes critical to metabolism and generation of ATP, which is the primary source of energy for cellular processes.
  • REN001 has been shown to increase transcription of genes involved in mitochondrial function and increase fatty acid oxidation, and may increase production of new mitochondria.\n'

Mitochondrial DNA Analysis Is Added to OmniTier’s CompStor® Family of Genomics Secondary and Tertiary Analysis Appliances

Retrieved on: 
Monday, March 1, 2021
Data management, Biotechnology, Technology, Health, General Health, Other Technology, Medical devices, Research, Software, Science, Hardware, Branches of biology, Genetics, Biology, DNA, Genomics, Mitochondrial genetics, Genetic mapping, Cellular respiration, Mitochondrion, Mitochondrial DNA, Human mitochondrial genetics, Genome, Mitochondrial DNA analysis, CompStor Novos®, CompStor Insight™, OmniTier

OmniTier announced today that its CompStor family now supports mitochondrial analysis in both its secondary and tertiary analysis appliances.

Key Points: 
  • OmniTier announced today that its CompStor family now supports mitochondrial analysis in both its secondary and tertiary analysis appliances.
  • Variant calling on the mitochondrial genome must overcome additional challenges that are not present in standard nuclear genome analysis.
  • Because mitochondrial DNA is circular, standard linear analysis produces errors at the ostensible extremities of the mitochondrial sequence.
  • In addition, the number of types of mitochondrial DNA that may be present in a single sample is not simply bounded.

Black Friday 2019 DNA Test Kit Deals: List of Early AncestryDNA & 23andMe Deals Shared by Retail Egg

Retrieved on: 
Sunday, November 24, 2019
Branches of biology, Genetics, Retailing, Applied genetics, Genealogy websites, DNA, Walmart, 23andMe, Amazon, Black Friday, Mitochondrial DNA

For the full range of live deals check out Amazon's Black Friday deals page and Walmart's Deal Drop page .

Key Points: 
  • For the full range of live deals check out Amazon's Black Friday deals page and Walmart's Deal Drop page .
  • Retail Egg earns commissions from purchases made using the links provided.
  • Although Ancestry DNA tests autosomal DNA, 23andMe is more extensive as they also test yDNA and mtDNA.
  • Amazon delivers new deals daily in addition to the thousands of discounted products already available during their Black Friday sales.

Mitochondrial Disease Therapies Market, 2019-2030

Retrieved on: 
Wednesday, October 16, 2019
Branches of biology, Mitochondrial genetics, Biology, Molecular biology, Mitochondrial diseases, Mitochondrial disease, Mitochondrial DNA, Mitochondrion, Human mitochondrial genetics, MERRF syndrome, Taosheng Huang

DUBLIN, Oct. 16, 2019 /PRNewswire/ -- The "Mitochondrial Disease Therapies Market, 2019-2030" report has been added to ResearchAndMarkets.com's offering.

Key Points: 
  • DUBLIN, Oct. 16, 2019 /PRNewswire/ -- The "Mitochondrial Disease Therapies Market, 2019-2030" report has been added to ResearchAndMarkets.com's offering.
  • The Mitochondrial Disease Therapies Market, 2019-2030 report features an extensive study of the current market landscape, offering an informed opinion on the likely adoption of therapeutics designed to treat mitochondrial diseases.
  • The chapter lays emphasis on genetic diseases caused due to mutations in the mitochondrial DNA and clinical conditions that are associated with mitochondrial dysfunction.
  • Chapter 10 features a detailed market forecast analysis, highlighting the likely growth of mitochondrial disease therapies till the year 2030.

Mothers Know Best: How Egg Cells Choose Their Best Powerhouses to Pass On

Retrieved on: 
Wednesday, May 15, 2019
Branches of biology, Biology, Mitochondrial genetics, Genomics, DNA, Mitochondrial DNA, Senescence, Mitochondrion, Genome, Ageing, Extranuclear inheritance, Paternal mtDNA transmission

A new study in fruit flies, published online May 15 in Nature, shows how the testing is done.

Key Points: 
  • A new study in fruit flies, published online May 15 in Nature, shows how the testing is done.
  • The work focuses on mitochondria, the cellular machines that turn the sugars, fats and proteins we eat into energy used by the body's millions of cells.
  • Led by researchers at NYU School of Medicine and the University of Toronto, the research team used a direct imaging technique to watch for the first time as maternal reproductive cells carefully choose which mitochondria to pass on.
  • Unlike the much larger DNA sets (genomes) residing in the nuclei of cells, mtDNA is only passed on through the mothers' egg cells.

Leading mitochondrial DNA researcher discusses causes of common complex diseases at Feinstein Institute Marsh Lecture

Retrieved on: 
Thursday, June 21, 2018
Biology, Mitochondrial genetics, Cellular respiration, Mitochondria, Mitochondrion, Mitochondrial DNA, Human mitochondrial genetics, Leonard Marsh

Dr. Wallace discussed his research to determine the mitochondrial causes of common "complex" diseases.

Key Points: 
  • Dr. Wallace discussed his research to determine the mitochondrial causes of common "complex" diseases.
  • The mitochondria also contain their own DNA, the mitochondrial DNA (mtDNA), which encodes the wiring diagram for the cell's power plants.
  • The Feinstein Institute's Marsh Lecture was established as a forum for renowned scientists to share their expertise with Feinstein Institute investigators.
  • Made possible by an endowment from the late Leonard Marsh and his family, the Marsh Lecture honors the memory of Leonard Marsh, co-founder of Snapple Beverage Corporation and a major supporter of the Feinstein Institute.

Mode of Action of the Mitochondrial Clinical-stage Drug Candidate Kh176: Two Birds, One Stone

Retrieved on: 
Thursday, April 26, 2018
Biology, Senescence, Mitochondrial genetics, Free radicals, Mitochondria, Cellular respiration, Reactive oxygen species, Mitochondrion, Mitochondrial disease, Mitochondrial DNA, Oxidative stress

KH176 is an orally bio-available small molecule in development by Khondrion for the treatment of mitochondrial (-related) diseases.

Key Points: 
  • KH176 is an orally bio-available small molecule in development by Khondrion for the treatment of mitochondrial (-related) diseases.
  • The present study reports on the early development and selection of KH176 as Khondrion's lead candidate and further explains its mode of action in primary cells obtained from mitochondrial patients.
  • "Elevated Reactive Oxygen Species (ROS) levels and a high sensitivity to redox-stress are two frequent cellular consequences in mitochondrial disease.
  • KH176 displays a dual mode of action, targeting both ROS and Redox disturbances.