Epithelium

• and computational modeling capabilities were instrumental for the characterization of NLRX1 as a therapeutic target for autoimmune diseases and the development of NX-13.
• “Importantly, AbbVie is one of the world’s largest biopharma companies with an incredibly successful I&I franchise that it has built over the last two decades.
• In addition to Landos Biopharma, Dr. Bassaganya-Riera founded NImmune Biopharma (“NImmune”) with the purpose to advance the clinical development of the LANCL2 portfolio of immunoregulatory precision medicines.
• Both omilancor and NIM-1324 are guided by precision biomarkers discovered and developed by NIMML’s TITAN-X A.I.-powered Precision Medicine platform.

• Pixel assesses live cell function at single-cell resolution, allowing scientists to simultaneously monitor cell viability, morphology, electrophysiology, metabolism, and more while generating electrical ‘images’ with single-cell spatial resolution.
• Pixel delivers simultaneous multi-modal, high-resolution readouts in 96- or 384-well plates, enabling cell monitoring and data collection at unprecedented scale.
• It’s widely applicable for in vitro cell biology applications including drug discovery, from target validation to toxicology screening.”
  CytoTronics’ early-access program for Pixel Primo empowers cell biologists to unlock applications that were previously inaccessible.
• The early-access program includes applications for endothelial and epithelial cells, cancer cell biology, mechanism of action/toxicology, stem cell biology, cardiac function, and neural function.

• But the imprint your finger leaves on the surface of the button is actually a 3D structure called a fingermark.
• A 2D fingerprint neglects the depth of the fingermark, including pores and scars buried in the ridges of fingers that are difficult to see.
• I’m an educator and scientist who studies holography, a field of research that focuses on how to display 3D information.

Fingermark types

• Patent fingermarks are the most visible type – bloody fingerprints at crime scenes are one example.
• Plastic fingermarks are found on soft surfaces, such as clay, Play-Doh or chocolate bars.
• Cyanoacrylate makes super glue in its liquid form, but as a gas it can make latent fingermarks visible.

Finally, Level 3 features, such as pores, scars and creases, are too small for the human eye to resolve. This is where optical techniques like holography come in handy, since optical wavelengths are in the order of microns, small enough to make out small details on an object.

Developing fingermark holograms

• Since fingermarks are usually collected as 2D pictures, and holograms display 3D information, my team wanted to develop a technique that can show all the 3D topological characteristics of a fingermark.
• Columnar thin films are dense pillars of glassy material that uniformly cover the fingermark, like a dense growth of identical trees in a forest.

• To make a hologram of something like a 3D fingermark, researchers split light from a laser into two parts.
• One part, called the reference wave, shines directly on a digital camera.
• The other wave shines on the object, in this case the fingermark.

Picking up fingermarks

• In 2017, our collaboration reported our first results, where we made 3D pictures of latent fingermarks using the CTF technique.
• We recorded holograms of the CTF-developed fingermarks with two different wavelengths of light – green and blue – generated from a laser.
• The Miami Valley Regional Crime Lab in Dayton, Ohio, has graded the quality of the fingermarks captured by Lakhtakia’s research group.

Partha Banerjee’s Holography and Metamaterials (HaM) Lab has used Digital Holography for many applications funded by DARPA, Air Force and Army. The current joint work on fingermarks is supported by a grant from the Criminal Investigations and Network Analysis (CINA) Center of the Department of Homeland Security (DHS).

• The "Global Claudin 18.2 Targeted Therapy Market Opportunity & Clinical Trials Insight 2028" report has been added to ResearchAndMarkets.com's offering.
• Small pharmaceutical companies working on CLDN18-targeting therapies are also becoming more visible in the pharmaceutical market.
• Therefore, CLDN18 and its variant CLDN18.2 are a ray of hope in the pharmaceutical industry, especially cancer therapy.
• Claudin 18.2 Targeted Drugs In Clinical Trials: > 60 Drugs
  Global Claudin 18.2 Drugs Clinical Trials By Company, Indication & Phase
  Claudin 18.2 Targeted Therapy Development Approaches: CAR T Cell Therapy, Bispecific Antibodies, Antibody Drug Conjugates