Birth control

• […]

  Prosecutor: In relation to Laura […] her cause of death was consistent with smothering?

• Prosecutor: And that she probably died from an acute catastrophic asphyxiating event of unknown causes?
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  Prosecutor: Are you able to say whether or not Caleb died from a catastrophic asphyxiating event of unknown causes?
• But there are good reasons for forensic medicine practitioners and advocates to rethink their understanding – and use – of these words.
• Read more:
  How 'witch-hunts' and 'Stockholm syndrome' became part of political language (and what it has to do with wrestling)

The semantic journey of asphyxia

• Predictably, this meaning “stoppage of pulse” then sprouted the meaning “stoppage of respiration” – a lack of breath is a salient sign of lifelessness.
• Subsequently, the path has been rocky, and it is now understood variously by forensic doctors around the world.
• What is agreed, however, is that “asphyxia” is not a diagnosis; it is not a condition that can be pointed at or diagnosed.

More murkiness

• As used by experts, this is synonymous with “may or may not mean”.
• Research shows, however, that people without expert knowledge hear the phrase as strong confirmation of the proposed connection.
• Clearly, we can’t assume people today would automatically understand “consistent with” as simply a way of saying what is proposed is possible.

Bad meanings drive out good

• The meanings we carry around in our heads seem so natural we fail to realise other people can have quite different understandings.
• And the more unusual a word is, the more its meanings will vary because we aren’t given the same opportunities to refine our hypotheses.
• All three meanings are out there, and different dictionaries favour different ones.

Asphyxia permeated Kathleen Folbigg’s trial

• (Two pinpoint scratches on Sarah’s lower lip were agreed to be of no significance).
• This was probably heard by the jury as indicating no injuries meant an “asphyxial event” had occurred – in other words, the children had been strangled or smothered.
• Known as Meadows Law, this inference stalked Kathleen Folbigg’s trial and her subsequent appeals relentlessly.
• All of this is medically incoherent and incapable of establishing anything of significance – but probably had a powerful effect on the jury.

'The wisdom of the crowd’

• In forensic pathology, it encompasses a number of concepts and is used variously by pathologists – and these uses are out of alignment with common lay usage.
• The jury system relies on “the wisdom of the crowd”.

Professor Cordner was an expert witness at both Commissions of Inquiry into the convictions of Kathleen Folbigg. Kate Burridge does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

• A drug that can halve the risk of developing breast cancer in post-menopausal women has been approved for use in the UK.
• This drug, called anastrozole, could benefit an estimated 289,000 women in the UK who are at increased risk of breast cancer.
• Anastrozole was already approved for use in the UK as a breast cancer treatment.
• The key to anaztrozole’s success both in treating and preventing breast cancer, is due to its effects on the body’s oestrogen levels.

• For TNG462, we dosed the first patient in the phase 1/2 trial in July 2023.
• Society for Immunotherapy of Cancer (SITC) 38th Annual Meeting, November 1-5, 2023, San Diego, CA
  In November 2023, Tango scientists presented preclinical data highlighting the potential of TNG260 in STK11-mutant cancers.
• AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, October 11-15, 2023, Boston, MA
  In October 2023, Tango scientists presented five posters highlighting preclinical data from the precision oncology pipeline and synthetic lethality discovery platform.
• The year-to-date increase is the result of out-licensing a program to Gilead for $5.0 million during the second quarter of 2023.

• "People living with active psoriatic arthritis who are treatment-resistant need options that improve debilitating symptoms of their disease, like pain, physical function and fatigue," said Philip Mease, M.D., Swedish Medical Center/Providence St. Joseph Health and University of Washington in Seattle, Washington.a "It is important that we assess patient-reported outcomes in a real-world setting, ensuring that we address unmet needs for people living with this challenging disease."
• "It is critical that we evaluate patient-reported outcomes to truly understand the lived experiences of patients and better develop and provide treatments in psoriatic disease."
• Dr. Philip Mease is a paid consultant for Janssen.
• He has not been compensated for any media work.