Bone

QSAM Biosciences Opens Enrollment of the Second Cohort of Patients in its Phase 1 Study of CycloSam® Targeting Metastatic Bone Cancer

Retrieved on: 
Wednesday, April 5, 2023

“We have met all criteria to continue patient enrollment at a higher dose level in the next group of patients,” stated Douglas R. Baum, CEO.

Key Points: 
  • “We have met all criteria to continue patient enrollment at a higher dose level in the next group of patients,” stated Douglas R. Baum, CEO.
  • The total dosage of the active radioisotope Samarium-153 to be received by participants in the second cohort is 50% higher than the total dose received by participants in the first cohort.
  • QSAM is dedicated to developing its Cyclosam® product for this important patient population, and patients with any of these bone cancer types are eligible for this clinical trial.
  • Osteosarcoma, while still a rare pediatric disease, is the most common form of bone cancer in children and young adults (ages 15-39) with primary high-grade bone malignancy; and Ewing’s Sarcoma bone cancer is the second most common form of bone cancer in children.

‘One meal a day’ diet popular with celebrities could do more harm than good – here’s why

Retrieved on: 
Wednesday, April 12, 2023

One of the latest trends among celebrities is the “one meal a day” diet (or “Omad”).

Key Points: 
  • One of the latest trends among celebrities is the “one meal a day” diet (or “Omad”).
  • Omad is essentially a more extreme version of other types of fasting diets, such as intermittent fasting and time-restricted eating.

Fasting and health

    • Or they are based on the assumption that if other forms of fasting can benefit health, then Omad will too.
    • And it has other health benefits such as lowering blood pressure.
    • One review study also found that many different types of fasting (including intermittent fasting and fasting every other day) can improve several aspects of metabolism.

Just one meal

    • For half of the study, participants ate these calories in a single meal, before switching and eating their daily calories split into three meals per day.
    • When participants ate just one meal per day, they saw a greater reduction in their body weight and fat mass.
    • However, participants also had greater reductions in lean mass and bone density when eating just one meal a day.
    • It will also be interesting to know whether the timing of the meal can further improve the results and if the nutritional profile of the meal makes a difference.

Other downsides

    • Not getting enough of these important nutrients could lead to loss of muscle mass, risk of constipation and poor gut health.
    • For most of us, this kind of diet could be unsustainable – and potentially harmful in the long run.

Bioretec is the first in the world to receive FDA approval for a bioresorbable metal product

Retrieved on: 
Thursday, March 30, 2023

Bioretec is the first and currently, the only medical device company to offer bioresorbable metal implants in the United States, the largest single market for orthopedic trauma products globally.

Key Points: 
  • Bioretec is the first and currently, the only medical device company to offer bioresorbable metal implants in the United States, the largest single market for orthopedic trauma products globally.
  • RemeOs™ trauma screws are based on a proprietary bioactive and osteopromotive magnesium alloy introducing a new generation of strong bioresorbable materials for enhanced surgical outcomes.
  • Bioresorbable metals combine the surgical techniques of traditional metal implants and the patient-friendly care and benefits of last-generation bioresorbable polymer implants.
  • Bioretec submitted the De Novo market authorization request to the FDA for the RemeOs™ trauma screw in May 2022.

Bioretec is the first in the world to receive FDA approval for a bioresorbable metal product

Retrieved on: 
Thursday, March 30, 2023

Bioretec is the first and currently, the only medical device company to offer bioresorbable metal implants in the United States, the largest single market for orthopedic trauma products globally.

Key Points: 
  • Bioretec is the first and currently, the only medical device company to offer bioresorbable metal implants in the United States, the largest single market for orthopedic trauma products globally.
  • RemeOs™ trauma screws are based on a proprietary bioactive and osteopromotive magnesium alloy introducing a new generation of strong bioresorbable materials for enhanced surgical outcomes.
  • Bioresorbable metals combine the surgical techniques of traditional metal implants and the patient-friendly care and benefits of last-generation bioresorbable polymer implants.
  • Bioretec submitted the De Novo market authorization request to the FDA for the RemeOs™ trauma screw in May 2022.

FDA approves Bioretec's RemeOs™ trauma screw as the first bioresorbable metal implant in the U.S. market

Retrieved on: 
Thursday, March 30, 2023

The RemeOs™ trauma screw is the first and currently only bioresorbable metal implant approved by the U.S. Food and Drug Administration (FDA).

Key Points: 
  • The RemeOs™ trauma screw is the first and currently only bioresorbable metal implant approved by the U.S. Food and Drug Administration (FDA).
  • Bioresorbable metals combine the surgical techniques of traditional metal implants and the patient-friendly care and benefits of last-generation bioresorbable polymer implants making implant removal operations redundant.
  • "This FDA market approval is the most important milestone in our company's history to date," comments Timo Lehtonen, CEO of Bioretec."
  • For the first time, that market is now offered a bioresorbable alternative to be used instead of titanium and steel implants.

FDA approves Bioretec's RemeOs™ trauma screw as the first bioresorbable metal implant in the U.S. market

Retrieved on: 
Thursday, March 30, 2023

The RemeOs™ trauma screw is the first and currently only bioresorbable metal implant approved by the U.S. Food and Drug Administration (FDA).

Key Points: 
  • The RemeOs™ trauma screw is the first and currently only bioresorbable metal implant approved by the U.S. Food and Drug Administration (FDA).
  • Bioresorbable metals combine the surgical techniques of traditional metal implants and the patient-friendly care and benefits of last-generation bioresorbable polymer implants making implant removal operations redundant.
  • "This FDA market approval is the most important milestone in our company's history to date," comments Timo Lehtonen, CEO of Bioretec."
  • For the first time, that market is now offered a bioresorbable alternative to be used instead of titanium and steel implants.

CoreLink Announces FDA Clearance of Siber® Ti--3D Printed SI Joint Fusion System

Retrieved on: 
Wednesday, March 29, 2023

ST. LOUIS, March 29, 2023 /PRNewswire/ -- CoreLink, LLC , a leading designer and manufacturer of innovative spinal implant systems announced today the 510(k) clearance from the U.S. Food and Drug Administration (FDA) for its Siber® Ti Sacroiliac Joint Fusion System .

Key Points: 
  • ST. LOUIS, March 29, 2023 /PRNewswire/ -- CoreLink, LLC , a leading designer and manufacturer of innovative spinal implant systems announced today the 510(k) clearance from the U.S. Food and Drug Administration (FDA) for its Siber® Ti Sacroiliac Joint Fusion System .
  • The Siber Ti System offers a comprehensive portfolio of fully porous, nano surfaced, 3D-printed implants.
  • *
    The system gives surgeons the ability to precisely fit patient anatomy and maximize points of fixation with numerous diameter and length options.
  • "CoreLink Surgical has proven their success in this space with a strong SI portfolio for over 7 years.

Study: Testosterone Pellet Therapy Significantly Improves Bone Density in Male Patient Case Report

Retrieved on: 
Monday, March 27, 2023

The results of “Subcutaneous Testosterone Pellet Therapy for Reversal of Male Osteoporosis: A Review and Case Report” were published in the peer-reviewed medical journal “The Aging Male,” the official journal of the International Society for the Study of the Aging Male.

Key Points: 
  • The results of “Subcutaneous Testosterone Pellet Therapy for Reversal of Male Osteoporosis: A Review and Case Report” were published in the peer-reviewed medical journal “The Aging Male,” the official journal of the International Society for the Study of the Aging Male.
  • After three months the patient’s testosterone level was up to 943 ng/dL, and after one year of continued testosterone therapy the patient’s repeated DEXA scan showed an improvement to his composite bone density, substantially normalizing his total hip bone density.
  • The patient also returned to performing triathlons one year after the beginning of testosterone pellet therapy.
  • Low testosterone in men is associated with a clear decrease in bone mineral density, which in turn is associated with a significant increase in bone fractures.

Conformis Launches Patient Awareness Campaign to Highlight the Benefits of Personalized Knee Replacement Procedures

Retrieved on: 
Tuesday, March 21, 2023

Independent surveys and Conformis market research show that most of the growing total knee replacement patient population is unaware of stark differences in knee replacement systems, and simply receives the brand of knee replacement system used most frequently by their surgeon.

Key Points: 
  • Independent surveys and Conformis market research show that most of the growing total knee replacement patient population is unaware of stark differences in knee replacement systems, and simply receives the brand of knee replacement system used most frequently by their surgeon.
  • Lower total direct costs for hospital admissions, with variables such as operative time and length of stay favoring fully personalized implants3.
  • The Conformis patient awareness campaign, whose primary television spot is seen here , is currently running in the Greater Boston-Seacoast New Hampshire and Metro Minneapolis-St. Paul markets through March.
  • For more information about Conformis and the company’s fully personalized and made-to-measure knee replacement systems, please visit www.conformis.com .

QSAM Biosciences to Provide Updates on its Clinical Trial at the Emerging Growth Conference on Wednesday, March 22, 2023

Retrieved on: 
Monday, March 20, 2023

Austin, TX, March 20, 2023 (GLOBE NEWSWIRE) -- QSAM Biosciences, Inc. (OTCQB: QSAM), a company developing next generation therapeutic radiopharmaceuticals, including Samarium-153-DOTMP (CycloSam®), for the treatment of bone cancer and related diseases and conditions, is pleased to announce that it has been invited to provide updates on its clinical trial evaluating CycloSam® for the treatment of metastatic bone cancer at the Emerging Growth Conference on Wednesday, March 22, 2023, at 2:50 PM EST.

Key Points: 
  • QSAM invites individual and institutional investors as well as advisors and analysts, to attend its real-time, interactive presentation at the Emerging Growth Conference.
  • The Emerging Growth Conference is a live, interactive online event that will give existing shareholders and the investment community the opportunity to interact with the Company’s executive officers.
  • Douglas Baum, the Company’s CEO, and other executive officers of QSAM will provide a presentation and may subsequently open the floor for questions.
  • Please register here to ensure you are able to attend the conference and receive any updates that are released: