Gustatory system

Feinstein Institutes Scientists Observe Vagus Nerve Stimulation Effect on Brain Activity

Retrieved on: 
Tuesday, June 22, 2021

The vagus nerve is a major therapeutic target for the emerging field of bioelectronic medicine, which uses neurostimulation to treat diseases.

Key Points: 
  • The vagus nerve is a major therapeutic target for the emerging field of bioelectronic medicine, which uses neurostimulation to treat diseases.
  • Electrically stimulating the vagus nerve is approved by the Food and Drug Administration as a non-pharmacological treatment for brain diseases, including epilepsy and depression.
  • While the links between the vagus nerve, body and the brain are well documented, the effects of VNS on brain function are complex and only partially understood.
  • The brain monitors and controls healthy organ function because it receives and processes information in the vagus nerve, said Kevin J. Tracey, MD , president and CEO of the Feinstein Institutes.

23andMe COVID-19 Study Finds Genetic Link to Loss of Smell Among COVID-19 patients

Retrieved on: 
Monday, June 7, 2021

Loss of smell and or taste, also called anosmia, is a hallmark symptom of COVID-19.

Key Points: 
  • Loss of smell and or taste, also called anosmia, is a hallmark symptom of COVID-19.
  • The researchers also found that among younger people with COVID-19 the loss of smell and taste was more common.
  • Among those aged 26-35, 73 percent reported loss of smell, whereas only 43 percent reported loss of smell in those 85 or older.
  • 23andMe has pioneered direct access to genetic information as the only company with multiple FDA authorizations for genetic health risk reports.

Vagus Nerve Stimulation Dose Thresholds Studied by Feinstein Institutes

Retrieved on: 
Friday, May 28, 2021
Key Points: 
  • View the full release here: https://www.businesswire.com/news/home/20210528005266/en/
    Stavros, Zanos, MD, PhD, from the Institute of Bioelectronic Medicine at the Feinstein Institutes.
  • Factors affecting VNS dose thresholds have not been studied before and, as a result, VNS treatments cannot be systematically calibrated.
  • Researchers developed acute and long-term vagus nerve implants to stimulate the vagus and measure thresholds in rats.
  • With the study of stimulation thresholds, scientists can maintain a consistent dose of stimulation in preclinical research and ultimately in clinical research of VNS.

electroCore, Inc. Celebrates Veterans and Active Members of the Military During National Military Appreciation Month

Retrieved on: 
Thursday, May 20, 2021

b'National Military Appreciation Month commemorates and expresses gratitude for the sacrifices current and former members of the U.S. armed forces have made for our country\xe2\x80\x99s freedom.

Key Points: 
  • b'National Military Appreciation Month commemorates and expresses gratitude for the sacrifices current and former members of the U.S. armed forces have made for our country\xe2\x80\x99s freedom.
  • The vagus nerve serves as the communication superhighway carrying information between the brain and internal organs and has a direct role in regulating pain in the human body.
  • "\ngammaCore Sapphire is available through the VA and in military treatment facilities at no charge to patients through Federal Supply Schedule (FSS) eligible entities which covers over nine million veterans and active military personnel.
  • Designed as a portable, easy-to-use technology, gammaCore can be self-administered by patients, as needed, without the potential side effects associated with commonly prescribed drugs.

SiteOne Therapeutics Announces $1.73M Grant from NIH/NHLBI and Adds Respiratory Advisory Team

Retrieved on: 
Tuesday, May 11, 2021

"Chronic cough is a prevalent respiratory disorder that is often unexplained or refractory, and severely impacts quality of life.

Key Points: 
  • "Chronic cough is a prevalent respiratory disorder that is often unexplained or refractory, and severely impacts quality of life.
  • We aim to develop a safe and effective local-acting inhaled antitussive to address the hypersensitivity of vagal afferents that is thought to drive chronic cough.
  • Cough is mediated by sensory nerve fibers of the vagus nerve that terminate in the upper airways and lungs.
  • Dr. Ford also holds senior advisory roles with PharmNovo and for New Leaf Venture Partners, where he had previously held the title of venture partner.

InventHelp Inventor Develops Hot Shot (NYS-109)

Retrieved on: 
Tuesday, April 27, 2021

b'PITTSBURGH, April 27, 2021 /PRNewswire/ -- "Every morning I enjoy a cup of coffee with a cigarette," said an inventor from Marrero, La.

Key Points: 
  • b'PITTSBURGH, April 27, 2021 /PRNewswire/ -- "Every morning I enjoy a cup of coffee with a cigarette," said an inventor from Marrero, La.
  • "This inspired me to think about opening a small business that would sell coffee containing a shot of liquor.
  • "\nShe instead developed the HOT SHOT, a tasty alternative to traditional alcoholic beverages, that would feature a novel and refreshing taste without a harsh aftertaste.
  • Additionally, it would be satisfying and perfectly blended.\nThe original design was submitted to the New Orleans sales office of InventHelp.

Worldwide Taste Modulators Industry to 2028 - by Type, Application and Region - ResearchAndMarkets.com

Retrieved on: 
Friday, April 23, 2021

b'4.2. Taste Modulators Market Value Chain Analysis, 2018 - 2028\n5.1. Taste Modulators Type dynamics & Market Share, 2021 & 2028\n6.1. Taste Modulators Application dynamics & Market Share, 2021 & 2028\n7.1. Taste Modulators Market share by region, 2021 & 2028\n'

Key Points: 

b'4.2. Taste Modulators Market Value Chain Analysis, 2018 - 2028\n5.1. Taste Modulators Type dynamics & Market Share, 2021 & 2028\n6.1. Taste Modulators Application dynamics & Market Share, 2021 & 2028\n7.1. Taste Modulators Market share by region, 2021 & 2028\n'

Global $22.4 Billion n-Flight Catering Services Market to 2025 - Rising Airline-Hotel Collaborations Benefit Market Prospects

Retrieved on: 
Tuesday, April 20, 2021

Airliners are building their brands in new and powerful ways by delighting customers with exquisite in-flight experiences.

Key Points: 
  • Airliners are building their brands in new and powerful ways by delighting customers with exquisite in-flight experiences.
  • Flying at high altitudes is known to reduce appetite and hunger thus making palatable airline food a challenge for food service providers.
  • The temporary changes in body chemistry also tend to alter the taste buds, requiring innovations in food science to confront this challenge.
  • Similarly, power juices, smoothies and power salads featuring good quality protein are also growing in popularity.

electroCore Announces Top Line Results from SAVIOR-1 study of Non-Invasive Vagus Nerve Stimulation (nVNS) in Hospitalized COVID-19 Patients

Retrieved on: 
Thursday, April 8, 2021

A total of 97 patients (47 treatment subjects and 50 control subjects) provided baseline demographic and medical history data.

Key Points: 
  • A total of 97 patients (47 treatment subjects and 50 control subjects) provided baseline demographic and medical history data.
  • The study was designed to evaluate the safety and feasibility of nVNS in addition to the current standard of care in patients hospitalized with active SARS-CoV-2 infection.
  • The patients clinical and biochemical endpoints were measured over their first five days of therapy and the adjusted means were compared.
  • When placed on a patients neck over the vagus nerve, gammaCore stimulates the nerves afferent fibers, which may lead to a reduction of pain in patients.

electroCore Announces Completion of Enrollment in SAVIOR-1 Study of Non-Invasive Vagus Nerve Stimulation (nVNS) in COVID-19 Patients Exhibiting Respiratory Symptoms

Retrieved on: 
Thursday, February 11, 2021

The SAVIOR-1 study enrolled 110 patients over 18 years of age with respiratory failure secondary to SARS-CoV-2 infection.

Key Points: 
  • The SAVIOR-1 study enrolled 110 patients over 18 years of age with respiratory failure secondary to SARS-CoV-2 infection.
  • Study subjects were randomized to either the study group receiving non-invasive vagus nerve stimulation (nVNS; gammaCore Sapphire) together with conventional treatment, or the control group receiving conventional treatment alone.
  • The study is also evaluating the safety of gammaCore Sapphire in patients hospitalized for COVID-19, in addition to the blood levels of proinflammatory cytokines in these patients.
  • When placed on the patient's neck over the vagus nerve, gammaCore stimulates afferent nerve fibers, which can lead to a reduction in pain for patients.