Feinstein Institute for Medical Research

Feinstein Institutes researchers turn on the vagus nerve, control the inflammatory reflex

Retrieved on: 
Wednesday, January 18, 2023
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For the first time, researchers at The Feinstein Institutes for Medical Research have shown the ability to turn on specific receptors in the vagus nerve, activating the inflammatory reflex.

Key Points: 
  • For the first time, researchers at The Feinstein Institutes for Medical Research have shown the ability to turn on specific receptors in the vagus nerve, activating the inflammatory reflex.
  • (Credit: Feinstein Institutes)
    The body releases inflammatory proteins to fight disease, which is part of the immune response.
  • The communication pathway, known as the inflammatory reflex, is signaled through the vagus nerve – the longest cranial nerve made up of more than 100,000 individual nerve fibers.
  • Through electrical signals, the brain, via the vagus nerve, can tell the body when to stop releasing inflammatory molecules.

Feinstein Institutes, Northwell Use Ultrasound to Treat Brain Tumors in Novel Clinical Trial

Retrieved on: 
Thursday, January 12, 2023
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View the full release here: https://www.businesswire.com/news/home/20230112005272/en/

Key Points: 
  • View the full release here: https://www.businesswire.com/news/home/20230112005272/en/
    Yehuda Haber (left) speaks with Dr. Michael Schulder about the Alpheus Medical ultrasound clinical trial.
  • (Credit: Feinstein Institutes)
    There are few therapeutic options to treat these recurrences for many patients diagnosed with high-grade gliomas, including glioblastoma.
  • This multi-site clinical trial looks to study the safety and optimal dosage of an investigational novel sonodynamic therapy (SDT) platform, which targets solid body cancers through ultrasound.
  • Schulder’s clinical research on brain tumors produces essential new knowledge to guide future therapeutic strategies.”
    Alpheus Medical is the sponsor of the trial.

Feinstein Institutes Researchers Discover a Molecule to Clear Invading Bacteria in Septic Patients

Retrieved on: 
Friday, January 6, 2023
Health, Biometrics, Other Health, General Health, Research, Science, Biotechnology, Immunosuppression, Feinstein Institute for Medical Research, Macrophage, Infection, Protein, Mouse, Bacteria, Medicine, Research, Septic, Death, Multimedia, Inflammation, Patient, Cytoskeleton, Radiation exposure, Foundation for the National Institutes of Health, Shock, Soft tissue injury, Immune system, Small intestinal bacterial overgrowth, RNA, Cell, Pharmaceutical industry, Vaccine, MD, Sepsis

(Credit Feinstein Institutes)

Key Points: 
  • (Credit Feinstein Institutes)
    The new study explores how extracellular cold-inducible RNA-binding protein (eCIRP) – an alarm molecule released during sepsis – causes immune dysfunction.
  • Specifically, eCIRP disrupts the cells within the immune system, which ingest bacteria and secrete both pro-inflammatory and antimicrobial mediators, known as macrophages.
  • “There is no single specific treatment for patients with sepsis and it remains an enigmatic disease for researchers globally,” said Dr. Wang, professor and chief scientific officer at the Feinstein Institutes.
  • “By reducing eCIRP molecules, we can lower the bacteria in septic patients and improve their outcome.

Michael Dowling Named America’s Most Influential Health Care Leader

Retrieved on: 
Monday, December 5, 2022
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Northwell Health President and CEO Michael Dowling , who championed innovation to combat the COVID-19 pandemic and was just as aggressive toward health equity and gun violence as a public health crisis, has been selected as Americas most influential leader in health care by Modern Healthcare.

Key Points: 
  • Northwell Health President and CEO Michael Dowling , who championed innovation to combat the COVID-19 pandemic and was just as aggressive toward health equity and gun violence as a public health crisis, has been selected as Americas most influential leader in health care by Modern Healthcare.
  • View the full release here: https://www.businesswire.com/news/home/20221205005551/en/
    Northwell Health President and CEO Michael Dowling.
  • As leader of New York States largest health care provider and private employer, Mr. Dowling guided Northwell Health through the darkest days of the First Wave and then worked to upend health inequalities laid bare by the pandemic.
  • Our 81,000 employees 18,900 nurses and 4,900 employed doctors, including members of Northwell Health Physician Partners are working to change health care for the better.

A novel azapeptide editing method provides potential for new drug development, Feinstein Institutes research shows

Retrieved on: 
Monday, November 28, 2022
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Azapeptides are one type of peptide alternative that has shown great potential as therapeutics, exemplified by the HIV drug, Atazanavir (Reyataz).

Key Points: 
  • Azapeptides are one type of peptide alternative that has shown great potential as therapeutics, exemplified by the HIV drug, Atazanavir (Reyataz).
  • View the full release here: https://www.businesswire.com/news/home/20221128005470/en/
    Dr. Yousef Al-Abed is co-director of the Institute of Bioelectrionic Medicine at the Feinstein Institutes for Medical Research.
  • A technology that circumvents these problems inherent to native peptides will change the future landscape of drug discovery, said Dr. Al-Abed.
  • The Feinstein Institutes for Medical Research is the research arm of Northwell Health, the largest health care provider and private employer in New York State.

Feinstein Institutes awarded $3.6M from New York State for spinal cord injury research

Retrieved on: 
Wednesday, November 23, 2022
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When someone suffers a spinal cord injury (SCI) it can lead to paralysis, sometimes in all four limbs.

Key Points: 
  • When someone suffers a spinal cord injury (SCI) it can lead to paralysis, sometimes in all four limbs.
  • View the full release here: https://www.businesswire.com/news/home/20221123005090/en/
    Prof. Chad Bouton vice president of advanced engineering and professor at the Institute of Bioelectronic Medicine at the Feinstein Institutes will lead the study.
  • New York State support of this project comes at a critical time as advances in bioelectronic medicine continue to make progress towards enhancing mobility in patients with spinal cord injury, said Kevin J. Tracey, MD , president and CEO of the Feinstein Institutes and Karches Family Distinguished Chair in Medical Research.
  • The Feinstein Institutes for Medical Research is the home of the research institutes of Northwell Health, the largest health care provider and private employer in New York State.

Feinstein Institutes lupus researchers recognized with top honors

Retrieved on: 
Thursday, November 17, 2022
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Anne Davidson (left) and Betty Diamond received top honors from the American College of Rheumatology (ACR) and the Association of Rheumatology Professionals.

Key Points: 
  • Anne Davidson (left) and Betty Diamond received top honors from the American College of Rheumatology (ACR) and the Association of Rheumatology Professionals.
  • Dr. Diamond is the director of the Institute of Molecular Medicine at the Feinstein Institutes and a pioneer in the basic science research of autoimmune diseases, particularly systemic lupus erythematosus.
  • The Feinstein Institutes for Medical Research is the home of the research institutes of Northwell Health, the largest health care provider and private employer in New York State.
  • Encompassing 50 research labs, 3,000 clinical research studies and 5,000 researchers and staff, the Feinstein Institutes raises the standard of medical innovation through its five institutes of behavioral science, bioelectronic medicine, cancer, health system science, and molecular medicine.

AI Digital Tool Predicts Covid-19 Patient Prognosis

Retrieved on: 
Tuesday, November 15, 2022
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The Feinstein Institutes for Medical Research scientists saw early potential in using diverse patient population data from Northwell Health New York's largest health system and developed a clinical tool to better inform frontline staff on a patients prognosis and severity of the disease.

Key Points: 
  • The Feinstein Institutes for Medical Research scientists saw early potential in using diverse patient population data from Northwell Health New York's largest health system and developed a clinical tool to better inform frontline staff on a patients prognosis and severity of the disease.
  • View the full release here: https://www.businesswire.com/news/home/20221115006164/en/
    Dr. Theo Zanos led the research that created a self-monitoring, auto-updating artificial intelligence (AI) model clinical support tool.
  • Current predictive models for COVID-19 patients do not account for real-time shifts in patient characteristics and outcomes.
  • The Feinstein Institutes continue to lead in the study of AI and machine learning clinical support tools.

Feinstein Institutes’ Valentin Pavlov Elected President of the International Society for Autonomic Neuroscience

Retrieved on: 
Wednesday, November 9, 2022
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The International Society for Autonomic Neuroscience (ISAN) has elected The Feinstein Institutes for Medical Research's Valentin Pavlov, PhD , as president in recognition of his dedication and research of the brain and autonomic nervous system, particularly in the regulation of inflammation and metabolism.

Key Points: 
  • The International Society for Autonomic Neuroscience (ISAN) has elected The Feinstein Institutes for Medical Research's Valentin Pavlov, PhD , as president in recognition of his dedication and research of the brain and autonomic nervous system, particularly in the regulation of inflammation and metabolism.
  • View the full release here: https://www.businesswire.com/news/home/20221109005208/en/
    Dr. Valentin Pavlov is a professor at the Feinstein Institutes Institute of Bioelectronic Medicine.
  • It is a privilege and honor to take up the mantle of president for the International Society for Autonomic Neuroscience.
  • Dr. Pavlov's election to president of the International Society for Autonomic Neuroscience is timely evidence of his leadership in bioelectronic medicine, said Kevin J. Tracey, MD , president and CEO of the Feinstein Institutes and Karches Family Distinguished Chair in Medical Research.

New Digital Tool Dramatically Reduces Blood Clot Risk During and Post-Hospital Care, Feinstein Institutes Study Shows

Retrieved on: 
Monday, November 7, 2022
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View the full release here: https://www.businesswire.com/news/home/20221107005864/en/

Key Points: 
  • View the full release here: https://www.businesswire.com/news/home/20221107005864/en/
    Dr. Alex Spyropoulos research shows a better way to conduct patient care for those who are suffering from blood clots.
  • (Credit: Feinstein Institutes)
    Dr. Spyropoulos is a world-renowned expert in blood clots who shared critical COVID-19 research during the height of the pandemic.
  • Using the IMPROVE-DD VTE score, doctors can prescribe the appropriate thromboprophylaxis for patients at moderate and high risk of blood clots.
  • The Feinstein Institutes for Medical Research is the home of the research institutes of Northwell Health, the largest health care provider and private employer in New York State.