Antibiotics

Somatic Mutations in Single-Cell Sequencing: Separating Signal from Noise, Upcoming Webinar Hosted by Xtalks

Retrieved on: 
Monday, October 16, 2023

TORONTO, Oct. 16, 2023 /PRNewswire-PRWeb/ -- Discover a groundbreaking webinar delving into the development of SCAN2 and how this algorithm enables single-cell sequencing with high accuracy for somatic mutations. Somatic mutations arise due to DNA damage or errors in DNA synthesis and are propagated through cell division. Unlike inherited variants, somatic mutations are shared by only a fraction of the cells in an organism. Numerous algorithms have been developed to identify somatic mutations present in clonal populations in cancer cells. But, for non-cancer cells, the majority of somatic mutations — other than those that arise very early in development — are shared by very few cells or can even be private to a single cell. To identify such mutations, new detection techniques are required.

Key Points: 
  • In this free webinar, delve into the development of SCAN2 and how this algorithm enables single-cell sequencing with high accuracy for somatic mutations.
  • TORONTO, Oct. 16, 2023 /PRNewswire-PRWeb/ -- Discover a groundbreaking webinar delving into the development of SCAN2 and how this algorithm enables single-cell sequencing with high accuracy for somatic mutations.
  • Somatic mutations arise due to DNA damage or errors in DNA synthesis and are propagated through cell division.
  • Join this webinar to gain insights into the SCAN2 algorithm and how it enables single-cell sequencing with high accuracy for somatic mutations.

Biocomposites to host a symposium and present new STIMULAN® data at the European Bone and Joint Infection Society Annual Meeting

Retrieved on: 
Thursday, October 5, 2023

Findings from the study demonstrate the efficacy of STIMULAN® beads, when combined with vancomycin and gentamicin, in combating antibiotic tolerant biofilm-like aggregates.

Key Points: 
  • Findings from the study demonstrate the efficacy of STIMULAN® beads, when combined with vancomycin and gentamicin, in combating antibiotic tolerant biofilm-like aggregates.
  • Dr. Yvonne Achermann and I look forward to speaking on the merits of local antibiotic delivery in managing infection at this upcoming industry meeting."
  • Michael Harris, Chief Executive Officer of Biocomposites, added: "EBJIS is an important annual event at which surgeons, podiatrists and scientists catch up on the latest information in the field of bone and joint infection treatment.
  • Details of Biocomposites' symposium and the abstract accepted at the EBJIS Annual Meeting are listed below:
    Presenters: Mr.

Biocomposites to host a symposium and present new STIMULAN® data at the European Bone and Joint Infection Society Annual Meeting

Retrieved on: 
Thursday, October 5, 2023

Findings from the study demonstrate the efficacy of STIMULAN® beads, when combined with vancomycin and gentamicin, in combating antibiotic tolerant biofilm-like aggregates.

Key Points: 
  • Findings from the study demonstrate the efficacy of STIMULAN® beads, when combined with vancomycin and gentamicin, in combating antibiotic tolerant biofilm-like aggregates.
  • Dr. Yvonne Achermann and I look forward to speaking on the merits of local antibiotic delivery in managing infection at this upcoming industry meeting."
  • Michael Harris, Chief Executive Officer of Biocomposites, added: "EBJIS is an important annual event at which surgeons, podiatrists and scientists catch up on the latest information in the field of bone and joint infection treatment.
  • Details of Biocomposites' symposium and the abstract accepted at the EBJIS Annual Meeting are listed below:
    Presenters: Mr.

Most people who think they are allergic to penicillin aren't

Retrieved on: 
Wednesday, October 4, 2023

Allergies vary between us, but someone allergic to penicillin typically develops a rash, itching and swelling.

Key Points: 
  • Allergies vary between us, but someone allergic to penicillin typically develops a rash, itching and swelling.
  • Typically, it is made when using penicillin to treat a feverish child with signs of an infected ear or throat.
  • This is done because someone allergic to penicillin typically responds badly to the next dose of penicillin, which can include the potentially lethal condition known as anaphylaxis.
  • If you think you have a penicillin allergy it would be wise to discuss and confirm this with your doctor.

Aventa Genomics Announces Launch of Aventa FusionPlus, the First 3D Genomics Clinical Test for Patients with Solid Cancers

Retrieved on: 
Wednesday, October 4, 2023

The Aventa FusionPlus test incorporates 3D genomics technology, leveraging the preservation of spatial proximity of fused and rearranged genes for a 100 to a 1000-fold signal amplification and identification of novel breakpoints and fusion partners.

Key Points: 
  • The Aventa FusionPlus test incorporates 3D genomics technology, leveraging the preservation of spatial proximity of fused and rearranged genes for a 100 to a 1000-fold signal amplification and identification of novel breakpoints and fusion partners.
  • The test also utilizes proprietary analysis and reporting platforms to deliver a comprehensive assessment of the tumor.
  • “In previously characterized tumor specimens from patients with no known actionable driver, the Aventa FusionPlus test detected potentially actionable variants in half of the cases,” said Chris Roberts, Executive Director for Aventa Genomics.
  • “We thank Protean BioDiagnostics for this joint venture, and we believe that this is only the beginning for the use of 3D genomics technology in the clinical space.”

PHAXIAM Therapeutics and Vetophage Announce Strategic Research Collaboration

Retrieved on: 
Tuesday, October 3, 2023

Strategic research partnership between PHAXIAM Therapeutics and Vetophage, a biotechnology company specialized in veterinary phage therapy

Key Points: 
  • Strategic research partnership between PHAXIAM Therapeutics and Vetophage, a biotechnology company specialized in veterinary phage therapy
    Lyon (France) and Cambridge (MA, US), October 03, 2023 – 10:05 pm CEST – PHAXIAM Therapeutics (Nasdaq & Euronext: PHXM) and Vetophage, a company specialized in phage therapy applied to animal health, announce the signature of a long-term strategic research partnership to combine their expertise in the research of new phages and phage-derived proteins (endolysins) in the fight against antimicrobial resistance.
  • The company enables PHAXIAM Therapeutics to screen its broad phage and endolysin bank targeting highly antimicrobial-resistant infections.
  • This agreement gives PHAXIAM Therapeutics exclusive licensing options on specified phages and endolysins in human health from the Vetophage platform, to further strengthen its product portfolio.
  • « The agreement with Vetophage is a significant milestone for PHAXIAM Therapeutics' development in the fight against severe resistant infections.

KromaTiD & Noble Life Sciences Sign a Distribution & OEM Partnership Agreement

Retrieved on: 
Tuesday, October 3, 2023

LONGMONT, Colo. and SYKESVILLE, Md., Oct. 3, 2023 /PRNewswire/ -- KromaTiD and Noble Life Sciences have entered a distribution and OEM agreement for products and services that enable a complete analysis of novel cell and gene therapies' potential toxicity prior to an Investigational New Drug (IND) application.

Key Points: 
  • LONGMONT, Colo. and SYKESVILLE, Md., Oct. 3, 2023 /PRNewswire/ -- KromaTiD and Noble Life Sciences have entered a distribution and OEM agreement for products and services that enable a complete analysis of novel cell and gene therapies' potential toxicity prior to an Investigational New Drug (IND) application.
  • dGH SCREEN: the ultimate single-cell, high resolution genomic mapping tool providing an unbiased assessment of structural variants and their prevalence.
  • "With this strategic partnership, Noble Life Sciences and KromaTiD unite to offer comprehensive services to characterize the toxicity and efficacy of cell and gene therapy products.
  • Our combined service offering demonstrates our dedication to providing innovative solutions that propel our valued customers' products into clinical development," said Stephen Horrigan, Ph.D., Noble Life Sciences' Chief Scientific Officer.

PreCheck Health, Genomic Solutions to Change How Cancer Will Be Identified and Treated

Retrieved on: 
Monday, October 2, 2023

Thanks to cutting-edge genomic solutions through next-generation sequencing, precision medicine has been able to move forward through treatment optimization, effectiveness, and improved patient outcomes.

Key Points: 
  • Thanks to cutting-edge genomic solutions through next-generation sequencing, precision medicine has been able to move forward through treatment optimization, effectiveness, and improved patient outcomes.
  • Genomic Solutions to Change How Cancer Will Be Identified and Treated.
  • Recent breakthroughs in genomic research have paved the way for more personalized and targeted approaches to cancer diagnosis and treatment.
  • Key highlights of how genomic solutions are advancing cancer treatment:
    Precision Diagnostics: Genomic sequencing technologies have been a driving force in precision medicine.

Brush your teeth! Bad oral hygiene linked to cancer, heart attacks and renal failure

Retrieved on: 
Monday, October 2, 2023

It’s normal to have bacteria in your mouth. But harmful bacteria have been linked to a host of health problems. Medical scientist Glenda Davison and microbiologist Yvonne Prince, who have researched the oral cavity, explain why it’s so important to practise good oral hygiene.Can poor oral hygiene lead to serious diseases? Why and how? Abnormal bacterial communities in the oral cavity have been linked to liver disease, renal failure, cancers, heart disease and hypertension.

Key Points: 


It’s normal to have bacteria in your mouth. But harmful bacteria have been linked to a host of health problems. Medical scientist Glenda Davison and microbiologist Yvonne Prince, who have researched the oral cavity, explain why it’s so important to practise good oral hygiene.

Can poor oral hygiene lead to serious diseases? Why and how?

    • Abnormal bacterial communities in the oral cavity have been linked to liver disease, renal failure, cancers, heart disease and hypertension.
    • The oral cavity is the door to the gastrointestinal tract and the rest of the body.
    • This can lead to bleeding gums and oral diseases such as gingivitis and periodontitis.

How do problems in the mouth lead to other illnesses?

    • This disruption in the oral biota causes inflammation and the slow development of periodontitis, bleeding gums and tooth decay.
    • As the gum disease destroys the gum and begins to erode the bone, inflammatory molecules called cytokines can enter the blood stream.
    • Read more:
      Microbiome: certain gut microbes may warn of Alzheimer's disease long before the first symptoms begin

Where do bacteria in the body come from?

    • There are 39 trillion microbes in the human body, outnumbering the estimated 30 trillion human cells, and they inhabit almost every organ and crevice in the human body.
    • They can be found in the gut, skin, lung, seminal and vaginal fluid, eyes, scalp and mouth.
    • Most of these microbes come from our mothers and enter our bodies when we are born.

What should people do to avoid these risks?

    • To further support the balance of the bacteria in the mouth it is recommended that foods rich in antioxidants, such as fresh fruit and vegetables, are included in our diet.
    • Dentists also recommend avoiding the use of antibacterial mouth washes, which have been shown to disrupt the balance of microbes.
    • Elevated levels of stress and lack of exercise have also been linked to disruptions in the balance of the oral biota.