Urinary tract infection

• This press release features multimedia.
• View the full release here: https://www.businesswire.com/news/home/20240223169844/en/
  The CRL did not identify clinical safety or efficacy issues in the NDA, and the FDA did not request any new clinical trials to support the approval of cefepime-taniborbactam.
• The FDA requested additional chemistry, manufacturing, and controls (CMC) and related data about the drug, testing methods, and manufacturing process.
• “While we are disappointed with this setback, we maintain utmost confidence in cefepime-taniborbactam.

• University Medical Devices (UMD) today announced the closure of its first round of seed funding.
• Funds are earmarked to advance UMD’s infrastructure, covering regulatory, medical, legal, manufacturing, packaging, sales and marketing.
• This funding round represents a major step toward UMD achieving profitability and sustainability, with a strong emphasis on bringing its first product – MicroWash – to market.
• MicroWash plays a pivotal role in addressing the challenges posed by the “tripledemic” – flu, COVID and RSV – as well as other respiratory infections.

• PHILADELPHIA, March 5, 2024 /PRNewswire/ -- SENA Health announces its partnership with Inspira Health to support patients receiving Healing at Home clinical services.
• The home-based services deliver advanced-level care to eligible Inspira Health patients in the comfort of their own homes.
• "Inspira Health sets itself apart as a truly innovative and forward-thinking organization in the region," said Dr. Anthony Wehbe, Founder and CEO of SENA Health.
• Inspira Health, in collaboration with SENA, has recently obtained the CMS Acute Hospital Care at Home Waiver.

• But can they improve your mood, too?
• But the short answer, according to my team’s recently published research, is likely yes.
• The beneficial bacteria in probiotics become part of a community of other microscopic organisms living in your digestive system called the gut microbiome.

Studying mood in mice

• So how do you measure the mood of mice?
• We exposed them to poop from either stressed mice or normal mice by sprinkling soiled bedding in their enclosures.
• Microbes from the donor mice started to populate the gut microbiomes of the clean mice.
• Within a few weeks, the clean mice exposed to poop from stressed mice started to develop stress- and anxiety-like behavior, even though nothing else had changed.

Which bacteria affect mood?

• The results of our experiments led us back to our original question: Which bacteria can change your mood?
• In our analysis, we found that a group of bacteria called Lactobacillus was greatly reduced in the stressed mice.
• So we had to come up with a way to test how different strains affect anxious behavior.

• Instead of tackling this colossal task alone, we created a method that other microbiome scientists can also use to look at this group of bacteria as systematically as possible.
• To recreate the same experimental conditions for each species of microbe, we created a group of mice with only six species of bacteria in their microbiome, the bare minimum needed for normal and healthy development, which did not include Lactobacillus.

What’s next?

• We hope that our research will open avenues for other scientists to test different probiotics.
• In the meantime, give the Lactobacillus in your gut some love through a healthy, probiotics-rich diet.

Andrea Merchak has received funding from the National Institutes of Health (T32 NS115657, F31 AI174782).