Gate Neurosciences Doses First Subject in a Translational EEG Biomarker Study of Apimostinel, a Rapid-Acting Treatment for Acute Depressive Disorders
Gate Neurosciences is developing apimostinel to address urgent patient and evolving practice needs for a safe, rapid-acting, in-office treatment of acute depressive disorders such as postpartum and episodic depression, and depression with suicidality.
- Gate Neurosciences is developing apimostinel to address urgent patient and evolving practice needs for a safe, rapid-acting, in-office treatment of acute depressive disorders such as postpartum and episodic depression, and depression with suicidality.
- Apimostinel previously demonstrated proof-of-concept in a Phase 2a MDD study and the ongoing biomarker study aims to further enhance the understanding of dose dynamics using various electroencephalogram (EEG) measures after single and multiple ascending doses in 40 healthy subjects.
- Gate Neurosciences plans to use results from the EEG biomarker study to further de-risk dose selection in a confirmatory Phase 2b efficacy study of apimostinel planned for initiation in mid-2023.
- Gate Neurosciences is a precision medicine biotechnology company focused on advancing next-generation CNS treatments that address growing needs in mental health.