Generation

• A man named Hadi Matar has been charged with second-degree attempted murder.
• He is an American-born resident of New Jersey in his early twenties, whose parents emigrated from Lebanon.
• Review: Knife: Meditations After an Attempted Murder – Salman Rushdie (Jonathan Cape) Knife is very good at recalling Rushdie’s grim memories of the attack.

• “Let me offer this piece of advice to you, gentle reader,” he says: “if you can avoid having your eyelid sewn shut … avoid it.
• Here, for a number of reasons, Rushdie is not on such secure ground.
• Read more:
  How Salman Rushdie has been a scapegoat for complex historical differences

  Rushdie, who studied history at Cambridge University, described himself in Joseph Anton as “a historian by training”.

• Indeed, a speech he gave at PEN America in 2022 is reprinted in the book verbatim.
• For these intellectuals, principles of secular reason and personal liberty should always supersede blind conformity to social or religious authority.

Old-fashioned liberal principles

• In Knife, though, Rushdie the protagonist confronts a world where such liberal principles now appear old-fashioned.
• He claims “the groupthink of radical Islam” has been shaped by “the groupthink-manufacturing giants, YouTube, Facebook, Twitter”.
• But for many non-religious younger people, any notion of free choice also appears illusory, the anachronistic residue of an earlier age.
• Millennials and Generation Z are concerned primarily with issues of environmental catastrophe and social justice, and they tend to regard liberal individualism as both ineffective and self-indulgent.
• A new book traces how we got here, but lets neoliberal ideologues off the hook

Suffused in the culture of Islam

• The Satanic Verses itself is suffused in the culture of Islam as much as James Joyce’s Ulysses is suffused in the culture of Catholicism.
• In their hypothetical conversation, the author of Knife tries to convince his assailant of the value of such ambivalence.
• He protests how his notorious novel revolves around “an East London Indian family running a café-restaurant, portrayed with real love”.

Attachment to past traditions

• Rushdie discusses in Knife how, besides the Hindu legends of his youth, he has also been “more influenced by the Christian world than I realized”.
• He cites the music of Handel and the art of Michelangelo as particular influences.
• Yet this again highlights Rushdie’s attachments to traditions firmly rooted in the past.
• Part of James’s greatness lay in the way he was able to accommodate these radical shifts within his writing.

‘A curiously one-eyed book’

• Particularly striking are the immediacy with which he recalls the shocking assault, the black humour with which he relates medical procedures and the sense of “exhilaration” at finally returning home with his wife to Manhattan.
• Yet there are also many loose ends, and the book’s conclusion, that the assailant has in the end become “simply irrelevant” to him, is implausible.
• He insists he does not want to write “frightened” or “revenge” books.

• This was despite several brave comeback attempts by Milburn that likewise cited Pataudi as an example.
• Knife, by contrast, is a curiously one-eyed book, in a metaphorical, as well as a literal sense.

Paul Giles does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

• Bei Tests als therapeutisches Vakzin bei einem Melanom-Modell führte ARM-002TM in Kombination mit dem Immuncheckpoint-Inhibitor Anti-PD1 in 80 % der Fälle zu einer vollständigen Reaktion.
• Darüber hinaus können entwickelte Immunzellen zu einem lang anhaltenden immunologischen Gedächtnis führen, das Patienten vor späteren Krebsrückfällen schützen kann.
• Defence hat sich dafür entschieden, seinen AccuTOX®-Leitkandidaten zu testen, um einen Krebsimpfstoff der zweiten Generation zu entwickeln, da dieser bei einer intratumoralen Verabreichung in geringeren Dosierungen nachweislich die Antigenpräsentation in Krebszellen verbessert.
• Der Kern der Defence Therapeutics-Plattform besteht in der ACCUM®-Technologie, die einen präzisen Transport von Impfantigenen oder ADCs in intakter Form zu den Zielzellen ermöglicht.

• Highly selective oral SMARCA2 degrader, PRT7732, shows robust anti-tumor activity in vivo as monotherapy and in combination with chemotherapy, at well-tolerated doses
  Next Generation CDK4/6 Inhibitor, PRT3645, is highly effective in combination with other targeted therapies in preclinical models of breast cancer, CRC and NSCLC
  WILMINGTON, Del., April 09, 2024 (GLOBE NEWSWIRE) -- Prelude Therapeutics Incorporated (Nasdaq: PRLD), a clinical-stage precision oncology company, today announced the presentation of new preclinical data at the American Association for Cancer Research (AACR) Annual Meeting for its highly selective oral SMARCA2 degrader, its potentially best-in-class CDK9 inhibitor and its next-generation oral CDK4/6 inhibitor.
• “These presentations demonstrate our core competencies in medicinal chemistry and cancer biology to optimize and deliver compounds to the clinic with the potential to succeed as differentiated first- and/or best-in-class new therapies,” said Andrew Combs, Ph.D., Chief Chemistry Officer at Prelude Therapeutics.
• Peggy Scherle, Ph.D., Chief Scientific Officer at Prelude, stated, “Advancement of our second highly selective SMARCA2 degrader strengthens Prelude’s leadership position in the emerging use of SMARCA2 protein degradation as a potential treatment option for underserved patients with cancer.
• With both a first-in-class IV SMARCA2 degrader, PRT3789, in Phase 1 clinical development and now our oral SMARCA2 degrader, PRT7732, expected to enter the clinic later this year, we believe these distinct modalities may offer new therapies for patients with SMARCA4 mutations.”
  Details on the poster presentations are as follows:
  Identified potent, selective, well-tolerated and orally bioavailable SMARCA2 degrader, PRT7732
  PRT7732 exhibits >3000-fold selectivity for SMARCA2 over SMARCA4, with low nanomolar potency in cell based assays
  Title: PRT2527, a Novel Highly Selective Cyclin-Dependent Kinase 9 (CDK9) Inhibitor, Has Potent Antitumor Activity in Combination with BTK and BCL2 Inhibition in Various Lymphoid Malignancies
  PRT2527 is efficacious as monotherapy in preclinical models of DLBCL, CLL and MCL, and combines with both BTK and BCL2 inhibition to improve depth and duration of responses
  Title: The Brain Penetrant CDK4/6 Inhibitor, PRT3645, is Highly Effective in Combination with Other Targeted Therapies in Preclinical Models of Breast Cancer, CRC and NSCLC
  Next generation CDK4/6 inhibitor, PRT3645, demonstrates preclinical synergy with SERDs, as well as MEK1/2 and CDK2 inhibition

• “Connecting and communicating with young consumers in a safe, appropriate, and compliant manner is essential for Super League’s partners, and there is no better standard bearer in child-appropriate contextual content advertising than Common Sense Networks,” said Matt Edelman, President and Chief Commercial Officer of Super League.
• With an exclusive suite of proprietary dynamic content products and measurement tools, alongside the ability to harness Roblox’s Immersive Ads, Super League sits at the forefront of the marketplace.
• “The intersection of gaming and video content represents a dominant footprint for kids on digital platforms.
• Super League and Common Sense Networks will be rolling out one-of-a-kind, pioneering packages and programs with leading brands throughout the rest of 2024.